MTSS1: Difference between revisions

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Latest revision as of 20:20, 8 November 2017

Metastasis suppressor protein 1 is a protein that in humans is encoded by the MTSS1 gene.^[1]^[2]^[3] True to its name, it codes for a metastasis suppressor.

References

↑ Mattila PK, Salminen M, Yamashiro T, Lappalainen P (Mar 2003). "Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain". J Biol Chem. 278 (10): 8452–9. doi:10.1074/jbc.M212113200. PMID 12482861.
↑ Lee YG, Macoska JA, Korenchuk S, Pienta KJ (Jun 2002). "MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer". Neoplasia. 4 (4): 291–4. doi:10.1038/sj.neo.7900231. PMC 1531703. PMID 12082544.
↑ "Entrez Gene: MTSS1 metastasis suppressor 1".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Woodings JA, Sharp SJ, Machesky LM (2003). "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta". Biochem. J. 371 (Pt 2): 463–71. doi:10.1042/BJ20021962. PMC 1223315. PMID 12570871.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yamagishi A, Masuda M, Ohki T, et al. (2004). "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein". J. Biol. Chem. 279 (15): 14929–36. doi:10.1074/jbc.M309408200. PMID 14752106.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Nixdorf S, Grimm MO, Loberg R, et al. (2004). "Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines". Cancer Lett. 215 (2): 209–20. doi:10.1016/j.canlet.2004.05.002. PMID 15488640.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Callahan CA, Ofstad T, Horng L, et al. (2004). "MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription". Genes Dev. 18 (22): 2724–9. doi:10.1101/gad.1221804. PMC 528890. PMID 15545630.
Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE (2005). "Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4". J. Cell Biol. 168 (3): 453–63. doi:10.1083/jcb.200409078. PMC 2171717. PMID 15684034.
Bompard G, Sharp SJ, Freiss G, Machesky LM (2006). "Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B". J. Cell Sci. 118 (Pt 22): 5393–403. doi:10.1242/jcs.02640. PMID 16280553.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Utikal J, Gratchev A, Muller-Molinet I, et al. (2006). "The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation". Int. J. Cancer. 119 (10): 2287–93. doi:10.1002/ijc.22106. PMID 16921485.
Ma S, Guan XY, Lee TK, Chan KW (2007). "Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma". Hum. Pathol. 38 (8): 1201–6. doi:10.1016/j.humpath.2007.01.004. PMID 17442377.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[pmid12482861-1] Mattila PK, Salminen M, Yamashiro T, Lappalainen P (Mar 2003). "Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain". J Biol Chem. 278 (10): 8452–9. doi:10.1074/jbc.M212113200. PMID 12482861.

[pmid12082544-2] Lee YG, Macoska JA, Korenchuk S, Pienta KJ (Jun 2002). "MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer". Neoplasia. 4 (4): 291–4. doi:10.1038/sj.neo.7900231. PMC 1531703. PMID 12082544.

[entrez-3] "Entrez Gene: MTSS1 metastasis suppressor 1".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Metastasis suppressor protein 1''' is a [[protein]] that in humans is encoded by the ''MTSS1'' [[gene]].<ref name="pmid12482861">{{cite journal |vauthors=Mattila PK, Salminen M, Yamashiro T, Lappalainen P | title = Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain | journal = J Biol Chem | volume = 278 | issue = 10 | pages = 8452–9 |date=Mar 2003 | pmid = 12482861 | pmc =  | doi = 10.1074/jbc.M212113200 }}</ref><ref name="pmid12082544">{{cite journal |vauthors=Lee YG, Macoska JA, Korenchuk S, Pienta KJ | title = MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer | journal = Neoplasia | volume = 4 | issue = 4 | pages = 291–4 |date=Jun 2002 | pmid = 12082544 | pmc = 1531703 | doi = 10.1038/sj.neo.7900231 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MTSS1 metastasis suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9788| accessdate = }}</ref> True to its name, it codes for a [[metastasis suppressor]].
-| update_page = yes
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_MTSS1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d1k.
- | PDB = {{PDB2|2d1k}}, {{PDB2|2d1l}}
- | Name = Metastasis suppressor 1
- | HGNCid = 20443
- | Symbol = MTSS1
- | AltSymbols =; FLJ44694; KIAA0429; MIM; MIMA; MIMB
- | OMIM = 608486
- | ECnumber =
- | Homologene = 8841
- | MGIid = 2384818
- | GeneAtlas_image1 = PBB_GE_MTSS1_203036_s_at_tn.png
-  | GeneAtlas_image2 = PBB_GE_MTSS1_203037_s_at_tn.png
- | GeneAtlas_image3 = PBB_GE_MTSS1_210359_at_tn.png
- | Function = {{GNF_GO|id=GO:0003785 |text = actin monomer binding}} {{GNF_GO|id=GO:0005102 |text = receptor binding}}
- | Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030139 |text = endocytic vesicle}}
- | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007015 |text = actin filament organization}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0030035 |text = microspike biogenesis}} {{GNF_GO|id=GO:0030041 |text = actin filament polymerization}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9788
-    | Hs_Ensembl = ENSG00000170873
-    | Hs_RefseqProtein = NP_055566
-    | Hs_RefseqmRNA = NM_014751
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 8
-    | Hs_GenLoc_start = 125632212
-    | Hs_GenLoc_end = 125809840
-    | Hs_Uniprot = O43312
-    | Mm_EntrezGene = 211401
-    | Mm_Ensembl = ENSMUSG00000022353
-    | Mm_RefseqmRNA = NM_144800
-    | Mm_RefseqProtein = NP_659049
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 58771324
-    | Mm_GenLoc_end = 58912106
-    | Mm_Uniprot = Q8R1S4
-  }}
-}}
-'''Metastasis suppressor 1''', also known as '''MTSS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTSS1 metastasis suppressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9788| accessdate = }}</ref> True to its name, it codes for a [[metastasis suppressor]].
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 57: / Line 9: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
+*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
-*{{cite journal  | author=Ishikawa K, Nagase T, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307-13 |year= 1998 |pmid= 9455477 |doi=  }}
+*{{cite journal   |vauthors=Ishikawa K, Nagase T, Nakajima D, etal |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–13 |year= 1998 |pmid= 9455477 |doi=10.1093/dnares/4.5.307  }}
-*{{cite journal  | author=Lee YG, Macoska JA, Korenchuk S, Pienta KJ |title=MIM, a potential metastasis suppressor gene in bladder cancer. |journal=Neoplasia |volume=4 |issue= 4 |pages= 291-4 |year= 2003 |pmid= 12082544 |doi= 10.1038/sj.neo.7900231 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Woodings JA, Sharp SJ, Machesky LM |title=MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 463–71 |year= 2003 |pmid= 12570871 |doi= 10.1042/BJ20021962  | pmc=1223315 }}
-*{{cite journal  | author=Mattila PK, Salminen M, Yamashiro T, Lappalainen P |title=Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8452-9 |year= 2003 |pmid= 12482861 |doi= 10.1074/jbc.M212113200 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Woodings JA, Sharp SJ, Machesky LM |title=MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 463-71 |year= 2003 |pmid= 12570871 |doi= 10.1042/BJ20021962 }}
+*{{cite journal   |vauthors=Yamagishi A, Masuda M, Ohki T, etal |title=A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14929–36 |year= 2004 |pmid= 14752106 |doi= 10.1074/jbc.M309408200 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
-*{{cite journal  | author=Yamagishi A, Masuda M, Ohki T, ''et al.'' |title=A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14929-36 |year= 2004 |pmid= 14752106 |doi= 10.1074/jbc.M309408200 }}
+*{{cite journal   |vauthors=Nixdorf S, Grimm MO, Loberg R, etal |title=Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines |journal=Cancer Lett. |volume=215 |issue= 2 |pages= 209–20 |year= 2004 |pmid= 15488640 |doi= 10.1016/j.canlet.2004.05.002 }}
-*{{cite journal  | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Nixdorf S, Grimm MO, Loberg R, ''et al.'' |title=Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. |journal=Cancer Lett. |volume=215 |issue= 2 |pages= 209-20 |year= 2004 |pmid= 15488640 |doi= 10.1016/j.canlet.2004.05.002 }}
+*{{cite journal   |vauthors=Callahan CA, Ofstad T, Horng L, etal |title=MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription |journal=Genes Dev. |volume=18 |issue= 22 |pages= 2724–9 |year= 2004 |pmid= 15545630 |doi= 10.1101/gad.1221804  | pmc=528890 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE |title=Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4 |journal=J. Cell Biol. |volume=168 |issue= 3 |pages= 453–63 |year= 2005 |pmid= 15684034 |doi= 10.1083/jcb.200409078  | pmc=2171717 }}
-*{{cite journal  | author=Callahan CA, Ofstad T, Horng L, ''et al.'' |title=MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. |journal=Genes Dev. |volume=18 |issue= 22 |pages= 2724-9 |year= 2004 |pmid= 15545630 |doi= 10.1101/gad.1221804 }}
+*{{cite journal  |vauthors=Bompard G, Sharp SJ, Freiss G, Machesky LM |title=Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B |journal=J. Cell Sci. |volume=118 |issue= Pt 22 |pages= 5393–403 |year= 2006 |pmid= 16280553 |doi= 10.1242/jcs.02640 }}
-*{{cite journal  | author=Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE |title=Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. |journal=J. Cell Biol. |volume=168 |issue= 3 |pages= 453-63 |year= 2005 |pmid= 15684034 |doi= 10.1083/jcb.200409078 }}
+*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal  | author=Bompard G, Sharp SJ, Freiss G, Machesky LM |title=Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. |journal=J. Cell. Sci. |volume=118 |issue= Pt 22 |pages= 5393-403 |year= 2006 |pmid= 16280553 |doi= 10.1242/jcs.02640 }}
+*{{cite journal   |vauthors=Utikal J, Gratchev A, Muller-Molinet I, etal |title=The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation |journal=Int. J. Cancer |volume=119 |issue= 10 |pages= 2287–93 |year= 2006 |pmid= 16921485 |doi= 10.1002/ijc.22106 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+*{{cite journal  |vauthors=Ma S, Guan XY, Lee TK, Chan KW |title=Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma |journal=Hum. Pathol. |volume=38 |issue= 8 |pages= 1201–6 |year= 2007 |pmid= 17442377 |doi= 10.1016/j.humpath.2007.01.004 }}
-*{{cite journal  | author=Utikal J, Gratchev A, Muller-Molinet I, ''et al.'' |title=The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation. |journal=Int. J. Cancer |volume=119 |issue= 10 |pages= 2287-93 |year= 2006 |pmid= 16921485 |doi= 10.1002/ijc.22106 }}
-*{{cite journal  | author=Ma S, Guan XY, Lee TK, Chan KW |title=Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma. |journal=Hum. Pathol. |volume=38 |issue= 8 |pages= 1201-6 |year= 2007 |pmid= 17442377 |doi= 10.1016/j.humpath.2007.01.004 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=9788}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-8-stub}}
-{{WikiDoc Sources}}

MTSS1: Difference between revisions

Latest revision as of 20:20, 8 November 2017

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