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{{Infobox_gene}}
{{PBB_Controls
'''SH2 domain containing 3C''', also known as '''SH2D3C''', is a [[protein]] that in humans is encoded by the ''SH2D3C'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SH2D3C SH2 domain containing 3C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10044| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SH2 domain containing 3C
| HGNCid = 16884
| Symbol = SH2D3C
| AltSymbols =; CHAT; FLJ39664; NSP3; PRO34088
| OMIM = 604722
| ECnumber = 
| Homologene = 69145
| MGIid = 1351631
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007254 |text = JNK cascade}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10044
    | Hs_Ensembl = ENSG00000095370
    | Hs_RefseqProtein = NP_005480
    | Hs_RefseqmRNA = NM_005489
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 129540417
    | Hs_GenLoc_end = 129580869
    | Hs_Uniprot = Q8N5H7
    | Mm_EntrezGene = 27387
    | Mm_Ensembl = ENSMUSG00000059013
    | Mm_RefseqmRNA = XM_991278
    | Mm_RefseqProtein = XP_996372
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 32543081
    | Mm_GenLoc_end = 32577003
    | Mm_Uniprot = Q9QZS8
  }}
}}
'''SH2 domain containing 3C''', also known as '''SH2D3C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SH2D3C SH2 domain containing 3C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10044| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''Sh2d3c''' is a gene on human chromosome 9 that encodes an [[SH2 domain]] containing protein known as NSP3.  The mouse homologue is found on chromosome 2.  The NSP (Novel SH2-containing Protein) family of proteins contains three members, [[SH2D3A|NSP1]], [[BCAR3|NSP2]], and NSP3 (this protein), all of which have a similar architecture, with an [[N-terminus|N-terminal]] SH2 domain, a proline serine rich region, which contains consensus sequences for [[Mitogen-activated protein kinase|MAP kinase]] substrates, and a conserved [[C-terminus]], which binds to the [[BCAR1|Cas]] family of adapter proteins, and also shows homology to [[guanine nucleotide exchange factor|GEF]] domains.
{{PBB_Summary
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| summary_text =
}}


==References==
NSP3 was originally identified by three independent groups of researchers.<ref>{{cite journal | vauthors = Lu Y, Brush J, Stewart TA | title = NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway | journal = The Journal of Biological Chemistry | volume = 274 | issue = 15 | pages = 10047–52 | date = April 1999 | pmid = 10187783 | doi = 10.1074/jbc.274.15.10047 }}</ref><ref>{{cite journal | vauthors = Dodelet VC, Pazzagli C, Zisch AH, Hauser CA, Pasquale EB | title = A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A | journal = The Journal of Biological Chemistry | volume = 274 | issue = 45 | pages = 31941–6 | date = November 1999 | pmid = 10542222 | doi = 10.1074/jbc.274.45.31941 }}</ref><ref name=pmid10692442>{{cite journal | vauthors = Sakakibara A, Hattori S | title = Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways | journal = The Journal of Biological Chemistry | volume = 275 | issue = 9 | pages = 6404–10 | date = March 2000 | pmid = 10692442 | doi = 10.1074/jbc.275.9.6404 }}</ref>  The mouse homologue of NSP3 has been shown to have two distinct isoforms, generated by alternative splicing, that are expressed in different tissues.  The shorter isoform, known as Chat (Cas/[[NEDD9|Hef1]] associated signal transducer) is expressed in brain, lung, heart, kidney, muscle, liver, and intestine, while the larger isoform, known as Chat-H (the "H" is for Hematopoietic), is expressed in spleen, thymus, and lymph nodes.<ref name=pmid10692442/>  The two isoforms differ only in their N-terminus, which has been shown by one group to be important for membrane localization.<ref name=pmid17174122>{{cite journal | vauthors = Regelmann AG, Danzl NM, Wanjalla C, Alexandropoulos K | title = The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking | journal = Immunity | volume = 25 | issue = 6 | pages = 907–18 | date = December 2006 | pmid = 17174122 | doi = 10.1016/j.immuni.2006.09.014 }}</ref>
{{reflist|2}}
 
==Further reading==
Through its interaction with [[NEDD9|Hef1]], Chat-H, has been shown to be an important regulator of lymphocyte adhesion, acting upstream of Rap1 in the integrin activation pathway.<ref name=pmid17174122/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A | title = AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology | journal = Journal of Cellular Physiology | volume = 212 | issue = 3 | pages = 655–65 | date = September 2007 | pmid = 17427198 | pmc = 2640322 | doi = 10.1002/jcp.21059 }}
| citations =
* {{cite journal | vauthors = Vervoort VS, Roselli S, Oshima RG, Pasquale EB | title = Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling | journal = Gene | volume = 391 | issue = 1-2 | pages = 161–70 | date = April 2007 | pmid = 17270363 | pmc = 1876674 | doi = 10.1016/j.gene.2006.12.016 }}
*{{cite journal | author=Near RI, Zhang Y, Makkinje A, ''et al.'' |title=AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. |journal=J. Cell. Physiol. |volume=212 |issue= 3 |pages= 655-65 |year= 2007 |pmid= 17427198 |doi= 10.1002/jcp.21059 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Vervoort VS, Roselli S, Oshima RG, Pasquale EB |title=Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. |journal=Gene |volume=391 |issue= 1-2 |pages= 161-70 |year= 2007 |pmid= 17270363 |doi= 10.1016/j.gene.2006.12.016 }}
* {{cite journal | vauthors = Dail M, Kalo MS, Seddon JA, Côté JF, Vuori K, Pasquale EB | title = SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases | journal = The Journal of Biological Chemistry | volume = 279 | issue = 40 | pages = 41892–902 | date = October 2004 | pmid = 15272013 | doi = 10.1074/jbc.M402929200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Sakakibara A, Hattori S, Nakamura S, Katagiri T | title = A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 8 | pages = 6012–7 | date = February 2003 | pmid = 12486027 | doi = 10.1074/jbc.M207942200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Sakakibara A, Hattori S | title = Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways | journal = The Journal of Biological Chemistry | volume = 275 | issue = 9 | pages = 6404–10 | date = March 2000 | pmid = 10692442 | doi = 10.1074/jbc.275.9.6404 }}
*{{cite journal  | author=Dail M, Kalo MS, Seddon JA, ''et al.'' |title=SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41892-902 |year= 2004 |pmid= 15272013 |doi= 10.1074/jbc.M402929200 }}
* {{cite journal | vauthors = Dodelet VC, Pazzagli C, Zisch AH, Hauser CA, Pasquale EB | title = A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A | journal = The Journal of Biological Chemistry | volume = 274 | issue = 45 | pages = 31941–6 | date = November 1999 | pmid = 10542222 | doi = 10.1074/jbc.274.45.31941 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
* {{cite journal | vauthors = Lu Y, Brush J, Stewart TA | title = NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway | journal = The Journal of Biological Chemistry | volume = 274 | issue = 15 | pages = 10047–52 | date = April 1999 | pmid = 10187783 | doi = 10.1074/jbc.274.15.10047 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Regelmann AG, Danzl NM, Wanjalla C, Alexandropoulos K | title = The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking | journal = Immunity | volume = 25 | issue = 6 | pages = 907–18 | date = December 2006 | pmid = 17174122 | doi = 10.1016/j.immuni.2006.09.014 }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | author=Sakakibara A, Hattori S, Nakamura S, Katagiri T |title=A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6012-7 |year= 2003 |pmid= 12486027 |doi= 10.1074/jbc.M207942200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Sakakibara A, Hattori S |title=Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6404-10 |year= 2000 |pmid= 10692442 |doi= }}
*{{cite journal | author=Dodelet VC, Pazzagli C, Zisch AH, ''et al.'' |title=A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 31941-6 |year= 1999 |pmid= 10542222 |doi= }}
*{{cite journal | author=Lu Y, Brush J, Stewart TA |title=NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10047-52 |year= 1999 |pmid= 10187783 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|SH2D3C}}
* {{UCSC gene details|SH2D3C}}
 
{{gene-9-stub}}

Latest revision as of 03:10, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SH2 domain containing 3C, also known as SH2D3C, is a protein that in humans is encoded by the SH2D3C gene.[1]

Function

Sh2d3c is a gene on human chromosome 9 that encodes an SH2 domain containing protein known as NSP3. The mouse homologue is found on chromosome 2. The NSP (Novel SH2-containing Protein) family of proteins contains three members, NSP1, NSP2, and NSP3 (this protein), all of which have a similar architecture, with an N-terminal SH2 domain, a proline serine rich region, which contains consensus sequences for MAP kinase substrates, and a conserved C-terminus, which binds to the Cas family of adapter proteins, and also shows homology to GEF domains.

NSP3 was originally identified by three independent groups of researchers.[2][3][4] The mouse homologue of NSP3 has been shown to have two distinct isoforms, generated by alternative splicing, that are expressed in different tissues. The shorter isoform, known as Chat (Cas/Hef1 associated signal transducer) is expressed in brain, lung, heart, kidney, muscle, liver, and intestine, while the larger isoform, known as Chat-H (the "H" is for Hematopoietic), is expressed in spleen, thymus, and lymph nodes.[4] The two isoforms differ only in their N-terminus, which has been shown by one group to be important for membrane localization.[5]

Through its interaction with Hef1, Chat-H, has been shown to be an important regulator of lymphocyte adhesion, acting upstream of Rap1 in the integrin activation pathway.[5]

References

  1. ↑ "Entrez Gene: SH2D3C SH2 domain containing 3C".
  2. ↑ Lu Y, Brush J, Stewart TA (April 1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry. 274 (15): 10047–52. doi:10.1074/jbc.274.15.10047. PMID 10187783.
  3. ↑ Dodelet VC, Pazzagli C, Zisch AH, Hauser CA, Pasquale EB (November 1999). "A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A". The Journal of Biological Chemistry. 274 (45): 31941–6. doi:10.1074/jbc.274.45.31941. PMID 10542222.
  4. ↑ 4.0 4.1 Sakakibara A, Hattori S (March 2000). "Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways". The Journal of Biological Chemistry. 275 (9): 6404–10. doi:10.1074/jbc.275.9.6404. PMID 10692442.
  5. ↑ 5.0 5.1 Regelmann AG, Danzl NM, Wanjalla C, Alexandropoulos K (December 2006). "The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking". Immunity. 25 (6): 907–18. doi:10.1016/j.immuni.2006.09.014. PMID 17174122.

Further reading

External links

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