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{{Infobox_gene}}
{{PBB_Controls
'''Bile acid-CoA:amino acid N-acyltransferase''' is an [[enzyme]] that in humans is encoded by the ''BAAT'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=570| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)
| HGNCid = 932
| Symbol = BAAT
| AltSymbols =; BACAT; BAT; FLJ20300; MGC104432
| OMIM = 602938
| ECnumber = 
| Homologene = 1286
| MGIid = 106642
| GeneAtlas_image1 = PBB_GE_BAAT_206913_at_tn.png
| Function = {{GNF_GO|id=GO:0004759 |text = carboxylesterase activity}} {{GNF_GO|id=GO:0016290 |text = palmitoyl-CoA hydrolase activity}} {{GNF_GO|id=GO:0016410 |text = N-acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0047963 |text = glycine N-choloyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006544 |text = glycine metabolic process}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008206 |text = bile acid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 570
    | Hs_Ensembl = ENSG00000136881
    | Hs_RefseqProtein = NP_001692
    | Hs_RefseqmRNA = NM_001701
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 103162890
    | Hs_GenLoc_end = 103173578
    | Hs_Uniprot = Q14032
    | Mm_EntrezGene = 12012
    | Mm_Ensembl = ENSMUSG00000039653
    | Mm_RefseqmRNA = NM_007519
    | Mm_RefseqProtein = NP_031545
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 49510522
    | Mm_GenLoc_end = 49527606
    | Mm_Uniprot = Q91X34
  }}
}}
'''Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)''', also known as '''BAAT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=570| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.<ref name="entrez">{{cite web | title = Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=570| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the [[bile acid]] [[Moiety (chemistry)|moiety]] from the [[acyl-CoA]] [[thioester]] to either [[glycine]] or [[taurine]], the second step in the formation of bile acid-[[amino acid]] [[Brønsted–Lowry acid–base theory|conjugates]] which serve as detergents in the [[gastrointestinal tract]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|BAAT}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Johnson MR, Barnes S, Kwakye JB, Diasio RB |title=Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver. |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10227-33 |year= 1991 |pmid= 2037576 |doi=  }}
* {{cite journal  | vauthors=Johnson MR, Barnes S, Kwakye JB, Diasio RB |title=Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver. |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10227–33 |year= 1991 |pmid= 2037576 |doi=  }}
*{{cite journal  | author=Falany CN, Johnson MR, Barnes S, Diasio RB |title=Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. |journal=J. Biol. Chem. |volume=269 |issue= 30 |pages= 19375-9 |year= 1994 |pmid= 8034703 |doi=  }}
* {{cite journal  | vauthors=Falany CN, Johnson MR, Barnes S, Diasio RB |title=Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. |journal=J. Biol. Chem. |volume=269 |issue= 30 |pages= 19375–9 |year= 1994 |pmid= 8034703 |doi=  }}
*{{cite journal  | author=Lench NJ, Telford EA, Andersen SE, ''et al.'' |title=An EST and STS-based YAC contig map of human chromosome 9q22.3. |journal=Genomics |volume=38 |issue= 2 |pages= 199-205 |year= 1997 |pmid= 8954802 |doi= 10.1006/geno.1996.0616 }}
* {{cite journal  | vauthors=Lench NJ, Telford EA, Andersen SE |title=An EST and STS-based YAC contig map of human chromosome 9q22.3. |journal=Genomics |volume=38 |issue= 2 |pages= 199–205 |year= 1997 |pmid= 8954802 |doi= 10.1006/geno.1996.0616 |display-authors=etal}}
*{{cite journal  | author=Solaas K, Ulvestad A, Söreide O, Kase BF |title=Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts. |journal=J. Lipid Res. |volume=41 |issue= 7 |pages= 1154-62 |year= 2000 |pmid= 10884298 |doi=  }}
* {{cite journal  | vauthors=Solaas K, Ulvestad A, Söreide O, Kase BF |title=Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts. |journal=J. Lipid Res. |volume=41 |issue= 7 |pages= 1154–62 |year= 2000 |pmid= 10884298 |doi=  }}
*{{cite journal  | author=Sfakianos MK, Wilson L, Sakalian M, ''et al.'' |title=Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47270-5 |year= 2003 |pmid= 12239217 |doi= 10.1074/jbc.M207463200 }}
* {{cite journal  | vauthors=Sfakianos MK, Wilson L, Sakalian M |title=Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47270–5 |year= 2003 |pmid= 12239217 |doi= 10.1074/jbc.M207463200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Carlton VE, Harris BZ, Puffenberger EG, ''et al.'' |title=Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 91-6 |year= 2003 |pmid= 12704386 |doi= 10.1038/ng1147 }}
* {{cite journal  | vauthors=Carlton VE, Harris BZ, Puffenberger EG |title=Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 91–6 |year= 2003 |pmid= 12704386 |doi= 10.1038/ng1147 |display-authors=etal}}
*{{cite journal  | author=Wang H, Tamba M, Kimata M, ''et al.'' |title=Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 3 |pages= 611-8 |year= 2003 |pmid= 12763038 |doi=  }}
* {{cite journal  | vauthors=Wang H, Tamba M, Kimata M |title=Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 3 |pages= 611–8 |year= 2003 |pmid= 12763038 |doi=10.1016/S0006-291X(03)00808-8 |display-authors=etal}}
*{{cite journal  | author=O'Byrne J, Hunt MC, Rai DK, ''et al.'' |title=The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34237-44 |year= 2003 |pmid= 12810727 |doi= 10.1074/jbc.M300987200 }}
* {{cite journal  | vauthors=O'Byrne J, Hunt MC, Rai DK |title=The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34237–44 |year= 2003 |pmid= 12810727 |doi= 10.1074/jbc.M300987200 |display-authors=etal}}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
* {{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Pellicoro A, van den Heuvel FA, Geuken M, ''et al.'' |title=Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport. |journal=Hepatology |volume=45 |issue= 2 |pages= 340-8 |year= 2007 |pmid= 17256745 |doi= 10.1002/hep.21528 }}
* {{cite journal  | vauthors=Pellicoro A, van den Heuvel FA, Geuken M |title=Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport. |journal=Hepatology |volume=45 |issue= 2 |pages= 340–8 |year= 2007 |pmid= 17256745 |doi= 10.1002/hep.21528 |display-authors=etal}}
*{{cite journal  | author=Tougou K, Fukuda T, Ito T, ''et al.'' |title=Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals. |journal=Drug Metab. Pharmacokinet. |volume=22 |issue= 2 |pages= 125-8 |year= 2007 |pmid= 17495420 |doi=  }}
* {{cite journal  | vauthors=Tougou K, Fukuda T, Ito T |title=Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals. |journal=Drug Metab. Pharmacokinet. |volume=22 |issue= 2 |pages= 125–8 |year= 2007 |pmid= 17495420 |doi=10.2133/dmpk.22.125 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:24, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.[1]

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)".

External links

Further reading



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