RAB9A: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ras-related protein Rab-9A''' is a [[protein]] that in humans is encoded by the ''RAB9A'' [[gene]].<ref name="pmid9126495">{{cite journal | vauthors = Davies JP, Cotter PD, Ioannou YA | title = Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene | journal = Genomics | volume = 41 | issue = 1 | pages = 131–4 | date = May 1997 | pmid = 9126495 | pmc = | doi = 10.1006/geno.1997.4644 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAB9A RAB9A, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9367| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_RAB9A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1s8f.
| PDB = {{PDB2|1s8f}}, {{PDB2|1wms}}, {{PDB2|1yzl}}
| Name = RAB9A, member RAS oncogene family
| HGNCid = 9792
| Symbol = RAB9A
| AltSymbols =; RAB9
| OMIM = 300284
| ECnumber = 
| Homologene = 20900
| MGIid = 1890695
| GeneAtlas_image1 = PBB_GE_RAB9A_221808_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005770 |text = late endosome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9367
    | Hs_Ensembl = ENSG00000123595
    | Hs_RefseqProtein = NP_004242
    | Hs_RefseqmRNA = NM_004251
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 13617165
    | Hs_GenLoc_end = 13638546
    | Hs_Uniprot = P51151
    | Mm_EntrezGene = 56382
    | Mm_Ensembl = ENSMUSG00000040577
    | Mm_RefseqmRNA = NM_019773
    | Mm_RefseqProtein = NP_062747
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 161801364
    | Mm_GenLoc_end = 161823799
    | Mm_Uniprot = Q0PD48
  }}
}}
'''RAB9A, member RAS oncogene family''', also known as '''RAB9A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB9A RAB9A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9367| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
RAB9A has been shown to [[Protein-protein interaction|interact]] with [[RABEPK]],<ref name=pmid9230071>{{cite journal | vauthors = Díaz E, Schimmöller F, Pfeffer SR | title = A novel Rab9 effector required for endosome-to-TGN transport | journal = J. Cell Biol. | volume = 138 | issue = 2 | pages = 283–90 | date = July 1997 | pmid = 9230071 | pmc = 2138197 | doi = 10.1083/jcb.138.2.283 }}</ref> [[TIP47]]<ref name=pmid11359012>{{cite journal | vauthors = Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR | title = Role of Rab9 GTPase in facilitating receptor recruitment by TIP47 | journal = Science | volume = 292 | issue = 5520 | pages = 1373–6 | date = May 2001 | pmid = 11359012 | doi = 10.1126/science.1056791 }}</ref> and the [[Biogenesis of lysosome-related organelles complex 3]].<ref name="pmid20048159">{{cite journal | vauthors = Kloer DP, Rojas R, Ivan V, Moriyama K, van Vlijmen T, Murthy N, Ghirlando R, van der Sluijs P, Hurley JH, Bonifacino JS | title = Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9 | journal = J. Biol. Chem. | volume = 285 | issue = 10 | pages = 7794–7804 |date = March 2010 | pmid = 20048159 | pmc = 2844223 | doi =10.1074/jbc.M109.069088 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Shapiro AD, Pfeffer SR |title=Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides. |journal=J. Biol. Chem. |volume=270 |issue= 19 |pages= 11085-90 |year= 1995 |pmid= 7744738 |doi=  }}
*{{cite journal  | author=Soldati T, Riederer MA, Pfeffer SR |title=Rab GDI: a solubilizing and recycling factor for rab9 protein. |journal=Mol. Biol. Cell |volume=4 |issue= 4 |pages= 425-34 |year= 1993 |pmid= 8389620 |doi=  }}
*{{cite journal  | author=Davies JP, Cotter PD, Ioannou YA |title=Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. |journal=Genomics |volume=41 |issue= 1 |pages= 131-4 |year= 1997 |pmid= 9126495 |doi= 10.1006/geno.1997.4644 }}
*{{cite journal  | author=Díaz E, Schimmöller F, Pfeffer SR |title=A novel Rab9 effector required for endosome-to-TGN transport. |journal=J. Cell Biol. |volume=138 |issue= 2 |pages= 283-90 |year= 1997 |pmid= 9230071 |doi=  }}
*{{cite journal  | author=de Leeuw HP, Koster PM, Calafat J, ''et al.'' |title=Small GTP-binding proteins in human endothelial cells. |journal=Br. J. Haematol. |volume=103 |issue= 1 |pages= 15-9 |year= 1998 |pmid= 9792283 |doi=  }}
*{{cite journal  | author=Shisheva A, Chinni SR, DeMarco C |title=General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. |journal=Biochemistry |volume=38 |issue= 36 |pages= 11711-21 |year= 1999 |pmid= 10512627 |doi=  }}
*{{cite journal  | author=Carroll KS, Hanna J, Simon I, ''et al.'' |title=Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. |journal=Science |volume=292 |issue= 5520 |pages= 1373-6 |year= 2001 |pmid= 11359012 |doi= 10.1126/science.1056791 }}
*{{cite journal  | author=Orzaez D, de Jong AJ, Woltering EJ |title=A tomato homologue of the human protein PIRIN is induced during programmed cell death. |journal=Plant Mol. Biol. |volume=46 |issue= 4 |pages= 459-68 |year= 2001 |pmid= 11485202 |doi=  }}
*{{cite journal  | author=Michel F, Soler-Lopez M, Petosa C, ''et al.'' |title=Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. |journal=EMBO J. |volume=20 |issue= 22 |pages= 6180-90 |year= 2002 |pmid= 11707390 |doi= 10.1093/emboj/20.22.6180 }}
*{{cite journal  | author=Barbero P, Bittova L, Pfeffer SR |title=Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells. |journal=J. Cell Biol. |volume=156 |issue= 3 |pages= 511-8 |year= 2002 |pmid= 11827983 |doi= 10.1083/jcb.200109030 }}
*{{cite journal  | author=Hanna J, Carroll K, Pfeffer SR |title=Identification of residues in TIP47 essential for Rab9 binding. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7450-4 |year= 2002 |pmid= 12032303 |doi= 10.1073/pnas.112198799 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Walter M, Davies JP, Ioannou YA |title=Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes. |journal=J. Lipid Res. |volume=44 |issue= 2 |pages= 243-53 |year= 2004 |pmid= 12576506 |doi= 10.1194/jlr.M200230-JLR200 }}
*{{cite journal  | author=Seaman MN |title=Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. |journal=J. Cell Biol. |volume=165 |issue= 1 |pages= 111-22 |year= 2004 |pmid= 15078902 |doi= 10.1083/jcb.200312034 }}
*{{cite journal  | author=Chen L, DiGiammarino E, Zhou XE, ''et al.'' |title=High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40204-8 |year= 2004 |pmid= 15263003 |doi= 10.1074/jbc.M407114200 }}
*{{cite journal  | author=Ganley IG, Carroll K, Bittova L, Pfeffer S |title=Rab9 GTPase regulates late endosome size and requires effector interaction for its stability. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5420-30 |year= 2005 |pmid= 15456905 |doi= 10.1091/mbc.E04-08-0747 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Ganley IG, Pfeffer SR |title=Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells. |journal=J. Biol. Chem. |volume=281 |issue= 26 |pages= 17890-9 |year= 2006 |pmid= 16644737 |doi= 10.1074/jbc.M601679200 }}
*{{cite journal  | author=Aivazian D, Serrano RL, Pfeffer S |title=TIP47 is a key effector for Rab9 localization. |journal=J. Cell Biol. |volume=173 |issue= 6 |pages= 917-26 |year= 2006 |pmid= 16769818 |doi= 10.1083/jcb.200510010 }}
}}
{{refend}}


{{protein-stub}}
== Further reading ==
{{WikiDoc Sources}}
{{Refbegin | 2}}
* {{cite journal | vauthors = Shapiro AD, Pfeffer SR | title = Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides | journal = J. Biol. Chem. | volume = 270 | issue = 19 | pages = 11085–90 | year = 1995 | pmid = 7744738 | doi = 10.1074/jbc.270.19.11085 }}
* {{cite journal | vauthors = Soldati T, Riederer MA, Pfeffer SR | title = Rab GDI: a solubilizing and recycling factor for rab9 protein | journal = Mol. Biol. Cell | volume = 4 | issue = 4 | pages = 425–34 | year = 1993 | pmid = 8389620 | pmc = 300943 | doi = 10.1091/mbc.4.4.425 }}
* {{cite journal | vauthors = Díaz E, Schimmöller F, Pfeffer SR | title = A novel Rab9 effector required for endosome-to-TGN transport | journal = J. Cell Biol. | volume = 138 | issue = 2 | pages = 283–90 | year = 1997 | pmid = 9230071 | pmc = 2138197 | doi = 10.1083/jcb.138.2.283 }}
* {{cite journal | vauthors = de Leeuw HP, Koster PM, Calafat J, Janssen H, van Zonneveld AJ, van Mourik JA, Voorberg J | title = Small GTP-binding proteins in human endothelial cells | journal = Br. J. Haematol. | volume = 103 | issue = 1 | pages = 15–9 | year = 1998 | pmid = 9792283 | doi = 10.1046/j.1365-2141.1998.00965.x }}
* {{cite journal | vauthors = Shisheva A, Chinni SR, DeMarco C | title = General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications | journal = Biochemistry | volume = 38 | issue = 36 | pages = 11711–21 | year = 1999 | pmid = 10512627 | doi = 10.1021/bi990200r }}
* {{cite journal | vauthors = Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR | title = Role of Rab9 GTPase in facilitating receptor recruitment by TIP47 | journal = Science | volume = 292 | issue = 5520 | pages = 1373–6 | year = 2001 | pmid = 11359012 | doi = 10.1126/science.1056791 }}
* {{cite journal | vauthors = Orzaez D, de Jong AJ, Woltering EJ | title = A tomato homologue of the human protein PIRIN is induced during programmed cell death | journal = Plant Mol. Biol. | volume = 46 | issue = 4 | pages = 459–68 | year = 2001 | pmid = 11485202 | doi = 10.1023/A:1010618515051 }}
* {{cite journal | vauthors = Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Müller CW | title = Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family | journal = EMBO J. | volume = 20 | issue = 22 | pages = 6180–90 | year = 2002 | pmid = 11707390 | pmc = 125740 | doi = 10.1093/emboj/20.22.6180 }}
* {{cite journal | vauthors = Barbero P, Bittova L, Pfeffer SR | title = Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells | journal = J. Cell Biol. | volume = 156 | issue = 3 | pages = 511–8 | year = 2002 | pmid = 11827983 | pmc = 2173336 | doi = 10.1083/jcb.200109030 }}
* {{cite journal | vauthors = Hanna J, Carroll K, Pfeffer SR | title = Identification of residues in TIP47 essential for Rab9 binding | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7450–4 | year = 2002 | pmid = 12032303 | pmc = 124251 | doi = 10.1073/pnas.112198799 }}
* {{cite journal | vauthors = Walter M, Davies JP, Ioannou YA | title = Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes | journal = J. Lipid Res. | volume = 44 | issue = 2 | pages = 243–53 | year = 2004 | pmid = 12576506 | doi = 10.1194/jlr.M200230-JLR200 }}
* {{cite journal | vauthors = Seaman MN | title = Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer | journal = J. Cell Biol. | volume = 165 | issue = 1 | pages = 111–22 | year = 2004 | pmid = 15078902 | pmc = 2172078 | doi = 10.1083/jcb.200312034 }}
* {{cite journal | vauthors = Chen L, DiGiammarino E, Zhou XE, Wang Y, Toh D, Hodge TW, Meehan EJ | title = High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target | journal = J. Biol. Chem. | volume = 279 | issue = 38 | pages = 40204–8 | year = 2004 | pmid = 15263003 | doi = 10.1074/jbc.M407114200 }}
* {{cite journal | vauthors = Ganley IG, Carroll K, Bittova L, Pfeffer S | title = Rab9 GTPase regulates late endosome size and requires effector interaction for its stability | journal = Mol. Biol. Cell | volume = 15 | issue = 12 | pages = 5420–30 | year = 2005 | pmid = 15456905 | pmc = 532021 | doi = 10.1091/mbc.E04-08-0747 }}
* {{cite journal | vauthors = Ganley IG, Pfeffer SR | title = Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells | journal = J. Biol. Chem. | volume = 281 | issue = 26 | pages = 17890–9 | year = 2006 | pmid = 16644737 | pmc = 3650718 | doi = 10.1074/jbc.M601679200 }}
* {{cite journal | vauthors = Aivazian D, Serrano RL, Pfeffer S | title = TIP47 is a key effector for Rab9 localization | journal = J. Cell Biol. | volume = 173 | issue = 6 | pages = 917–26 | year = 2006 | pmid = 16769818 | pmc = 2063917 | doi = 10.1083/jcb.200510010 }}
{{Refend}}
 
{{PDB Gallery|geneid=9367}}
 
 
{{Gene-X-stub}}

Latest revision as of 08:48, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-9A is a protein that in humans is encoded by the RAB9A gene.[1][2]

Interactions

RAB9A has been shown to interact with RABEPK,[3] TIP47[4] and the Biogenesis of lysosome-related organelles complex 3.[5]

References

  1. ↑ Davies JP, Cotter PD, Ioannou YA (May 1997). "Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene". Genomics. 41 (1): 131–4. doi:10.1006/geno.1997.4644. PMID 9126495.
  2. ↑ "Entrez Gene: RAB9A RAB9A, member RAS oncogene family".
  3. ↑ Díaz E, Schimmöller F, Pfeffer SR (July 1997). "A novel Rab9 effector required for endosome-to-TGN transport". J. Cell Biol. 138 (2): 283–90. doi:10.1083/jcb.138.2.283. PMC 2138197. PMID 9230071.
  4. ↑ Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR (May 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science. 292 (5520): 1373–6. doi:10.1126/science.1056791. PMID 11359012.
  5. ↑ Kloer DP, Rojas R, Ivan V, Moriyama K, van Vlijmen T, Murthy N, Ghirlando R, van der Sluijs P, Hurley JH, Bonifacino JS (March 2010). "Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9". J. Biol. Chem. 285 (10): 7794–7804. doi:10.1074/jbc.M109.069088. PMC 2844223. PMID 20048159.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=RAB9A&oldid=1423018"