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{{ | '''N-acylglucosamine 2-epimerase''' is an [[enzyme]] that in humans is encoded by the ''RENBP'' [[gene]].<ref name="pmid1618798">{{cite journal | vauthors = Takahashi S, Inoue H, Miyake Y | title = The human gene for renin-binding protein | journal = J Biol Chem | volume = 267 | issue = 18 | pages = 13007–13 |date=Aug 1992 | pmid = 1618798 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RENBP renin binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5973| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.<ref name="entrez" | | summary_text = The gene product inhibits renin activity by forming a dimer with [[renin]], a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of [[N-acetylglucosamine]] to [[N-acetylmannosamine]], indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Inoue H, Takahashi S, Fukui K, Miyake Y |title=Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif |journal=J. Biochem. |volume=110 |issue= 4 |pages= 493–500 |year= 1992 |pmid= 1723410 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Takahashi S, Miura R, Miyake Y |title=A study on renin binding protein (RnBP) in the human kidney |journal=J. Biochem. |volume=97 |issue= 2 |pages= 671–7 |year= 1985 |pmid= 3924907 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Murakami K, Hirose S, Chino S, etal |title=Properties of renin-binding protein |journal=Clinical and experimental hypertension. Part A, Theory and practice |volume=4 |issue= 11–12 |pages= 2073–81 |year= 1983 |pmid= 6756682 |doi=10.3109/10641968209062372 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Faranda S, Frattini A, Vezzoni P |title=The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction |journal=Gene |volume=155 |issue= 2 |pages= 237–9 |year= 1995 |pmid= 7721097 |doi=10.1016/0378-1119(94)00810-F }} | ||
*{{cite journal | *{{cite journal |vauthors=van den Ouweland AM, Verdijk M, Kiochis P, etal |title=The human renin-binding protein gene (RENBP) maps in Xq28 |journal=Genomics |volume=21 |issue= 1 |pages= 279–81 |year= 1994 |pmid= 8088804 |doi= 10.1006/geno.1994.1259 }} | ||
*{{cite journal | *{{cite journal |vauthors=Knöll A, Schunkert H, Reichwald K, etal |title=Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males |journal=Hum. Mol. Genet. |volume=6 |issue= 9 |pages= 1527–34 |year= 1998 |pmid= 9285790 |doi=10.1093/hmg/6.9.1527 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse |journal=Genomics |volume=44 |issue= 1 |pages= 8–14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }} | ||
*{{cite journal | *{{cite journal |vauthors=Stäsche R, Hinderlich S, Weise C, etal |title=A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24319–24 |year= 1997 |pmid= 9305888 |doi=10.1074/jbc.272.39.24319 }} | ||
*{{cite journal | *{{cite journal |vauthors=Takahashi S, Takahashi K, Kaneko T, etal |title=Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase |journal=J. Biochem. |volume=125 |issue= 2 |pages= 348–53 |year= 1999 |pmid= 9990133 |doi= 10.1093/oxfordjournals.jbchem.a022293}} | ||
*{{cite journal | *{{cite journal |vauthors=Takahashi S, Kumagai M, Shindo S, etal |title=Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein) |journal=J. Biochem. |volume=128 |issue= 6 |pages= 951–6 |year= 2001 |pmid= 11098137 |doi= 10.1093/oxfordjournals.jbchem.a022846}} | ||
*{{cite journal | *{{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }} | ||
*{{cite journal | *{{cite journal |vauthors=Lapteva N, Nieda M, Ando Y, etal |title=Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 4 |pages= 1059–65 |year= 2001 |pmid= 11467860 |doi= 10.1006/bbrc.2001.5215 }} | ||
*{{cite journal | *{{cite journal |vauthors=Takahashi S, Ogasawara H, Takahashi K, etal |title=Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein) |journal=J. Biochem. |volume=131 |issue= 4 |pages= 605–10 |year= 2002 |pmid= 11926999 |doi= 10.1093/oxfordjournals.jbchem.a003140}} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR |title=GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8035–42 |year= 2003 |pmid= 12499362 |doi= 10.1074/jbc.M212127200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Bohlmeyer T, Ferdensi A, Bristow MR, etal |title=Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes |journal=J. Card. Fail. |volume=9 |issue= 1 |pages= 59–68 |year= 2003 |pmid= 12612874 |doi= 10.1054/jcaf.2003.6 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Latest revision as of 09:05, 10 September 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.[1][2]
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.[2]
References
Further reading
- Inoue H, Takahashi S, Fukui K, Miyake Y (1992). "Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif". J. Biochem. 110 (4): 493–500. PMID 1723410.
- Takahashi S, Miura R, Miyake Y (1985). "A study on renin binding protein (RnBP) in the human kidney". J. Biochem. 97 (2): 671–7. PMID 3924907.
- Murakami K, Hirose S, Chino S, et al. (1983). "Properties of renin-binding protein". Clinical and experimental hypertension. Part A, Theory and practice. 4 (11–12): 2073–81. doi:10.3109/10641968209062372. PMID 6756682.
- Faranda S, Frattini A, Vezzoni P (1995). "The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction". Gene. 155 (2): 237–9. doi:10.1016/0378-1119(94)00810-F. PMID 7721097.
- van den Ouweland AM, Verdijk M, Kiochis P, et al. (1994). "The human renin-binding protein gene (RENBP) maps in Xq28". Genomics. 21 (1): 279–81. doi:10.1006/geno.1994.1259. PMID 8088804.
- Knöll A, Schunkert H, Reichwald K, et al. (1998). "Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males". Hum. Mol. Genet. 6 (9): 1527–34. doi:10.1093/hmg/6.9.1527. PMID 9285790.
- Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
- Stäsche R, Hinderlich S, Weise C, et al. (1997). "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase". J. Biol. Chem. 272 (39): 24319–24. doi:10.1074/jbc.272.39.24319. PMID 9305888.
- Takahashi S, Takahashi K, Kaneko T, et al. (1999). "Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase". J. Biochem. 125 (2): 348–53. doi:10.1093/oxfordjournals.jbchem.a022293. PMID 9990133.
- Takahashi S, Kumagai M, Shindo S, et al. (2001). "Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein)". J. Biochem. 128 (6): 951–6. doi:10.1093/oxfordjournals.jbchem.a022846. PMID 11098137.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Lapteva N, Nieda M, Ando Y, et al. (2001). "Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray". Biochem. Biophys. Res. Commun. 285 (4): 1059–65. doi:10.1006/bbrc.2001.5215. PMID 11467860.
- Takahashi S, Ogasawara H, Takahashi K, et al. (2002). "Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein)". J. Biochem. 131 (4): 605–10. doi:10.1093/oxfordjournals.jbchem.a003140. PMID 11926999.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR (2003). "GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism". J. Biol. Chem. 278 (10): 8035–42. doi:10.1074/jbc.M212127200. PMID 12499362.
- Bohlmeyer T, Ferdensi A, Bristow MR, et al. (2003). "Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes". J. Card. Fail. 9 (1): 59–68. doi:10.1054/jcaf.2003.6. PMID 12612874.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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