Linitis plastica screening: Difference between revisions

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{{Linitis plastica}}
{{Linitis plastica}}
{{CMG}}{{AE}} {{STM}}
{{CMG}};{{AE}}{{HM}}


==Overview==
==Overview==
Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for ''CDH1'' gene mutations.<ref name=me>Hereditary diffuse gastric cancer. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer#definition Accessed on December 10, 2015</ref>
 
There is insufficient evidence to recommend routine screening for linitis plastica. However, for familial cases of inherited diffuse [[Stomach cancer|gastric cancer]], [[Genetic testing|genetic screening]] for [[CDH1 (gene)|CDH1]] gene mutation is available.


==Screening==
==Screening==
*Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for ''CDH1'' gene mutations.<ref name=me>Hereditary diffuse gastric cancer. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer#definition Accessed on December 10, 2015</ref>
*There is insufficient evidence to recommend routine screening for linitis plastica.<ref name="pmid2916797">{{cite journal |vauthors=Longo WE, Zucker KA, Zdon MJ, Modlin IM |title=Detection of early gastric cancer in an aggressive endoscopy unit |journal=Am Surg |volume=55 |issue=2 |pages=100–4 |year=1989 |pmid=2916797 |doi= |url=}}</ref>  
*Indication for prophylactic [[gastrectomy]] include CDH1 positive patients.<ref name="pmid20719348">{{cite journal| author=Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS| title=Prophylactic total gastrectomy for individuals with germline CDH1 mutation. | journal=Surgery | year= 2011 | volume= 149 | issue= 3 | pages= 347-55 | pmid=20719348 | doi=10.1016/j.surg.2010.07.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20719348  }} </ref>
*However, for familial cases of inherited diffuse [[Stomach cancer|gastric cancer]] [[Genetic testing|genetic screening]] for [[CDH1 (gene)|CDH1]] gene mutation is available.
**The disease [[penetrance]] for the hereditary form is 80%, resulting in a very high risk of developing the cancer.
*Screening for [[Stomach cancer|gastric cancer]]<nowiki/>s is usually carried out via [[Endoscopy|endoscopic]] [[biopsy]], however, in the case of linitis plastica, [[barium]] study may be more effective than [[endoscopy]]. The indistensibility of the gastric wall is detected easily with [[barium]].


==References==
==References==

Latest revision as of 19:50, 8 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

There is insufficient evidence to recommend routine screening for linitis plastica. However, for familial cases of inherited diffuse gastric cancer, genetic screening for CDH1 gene mutation is available.

Screening

  • There is insufficient evidence to recommend routine screening for linitis plastica.[1]
  • However, for familial cases of inherited diffuse gastric cancer genetic screening for CDH1 gene mutation is available.
  • Screening for gastric cancers is usually carried out via endoscopic biopsy, however, in the case of linitis plastica, barium study may be more effective than endoscopy. The indistensibility of the gastric wall is detected easily with barium.

References

  1. Longo WE, Zucker KA, Zdon MJ, Modlin IM (1989). "Detection of early gastric cancer in an aggressive endoscopy unit". Am Surg. 55 (2): 100–4. PMID 2916797.


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