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| ==Overview== | | ==Overview== |
| [[Central nervous system|Spinal and brain]] MRI may be helpful in the diagnosis of tabes dorsalis. Findings on MRI suggestive of tabes dorsalis include longitudinal T2-weighted hyperintensity in the [[dorsal columns]] of the [[spinal cord]], narrowing between the cervical [[Intervertebral disc|intervertebral discs]] and partial [[ankylosis]] of the cervical [[Intervertebral disc|disc]] space, bilateral high intensity signals on the T2 weighted sequence located in mesio[[Temporal|temporal,]] [[Insular cortex|insular]], [[Frontal lobe|frontal regions]], [[calcification]] of the [[ligamentum flavum]]. | | [[Central nervous system|Spinal and brain]] MRI may be helpful in the diagnosis of neurosyphilis. Findings on MRI suggestive of neurosyphilis include non specific [[white matter]] lesions (cerebral gummas or [[arteritis]]), hyperintensity in mesiotemporal lobes, cortical [[atrophy]] , c[[Cerebral infarction|erebral infarction]], hippocampal [[atrophy]], hyperintensities in multiple cortical areas and [[thalami]], intramedullary hyperintensity and spinal cord atrophy, longitudinal T2-weighted hyperintensity in the [[dorsal columns]] of the [[spinal cord]], narrowing between the cervical [[Intervertebral disc|intervertebral discs]] and partial [[ankylosis]] of the cervical [[Intervertebral disc|disc]] space, bilateral high intensity signals on the T2 weighted sequence located in mesiotemporal, [[Insular cortex|insular]], [[Frontal lobe|frontal regions]] and [[calcification]] of the [[ligamentum flavum]]. |
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| ==MRI== | | ==MRI== |
| [[Central nervous system|Spinal and brain]] MRI may be helpful in the diagnosis of tabes dorsalis. Findings on MRI suggestive of tabes dorsalis include: | | [[Central nervous system|Spinal and brain]] MRI may be helpful in the diagnosis of neurosyphilis. Findings on MRI suggestive of neurosyphilis include: |
| | *Non specific [[white matter]] lesions (cerebral gummas or [[arteritis]])<ref name="pmid7611026">{{cite journal| author=Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA| title=Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. | journal=AJNR Am J Neuroradiol | year= 1995 | volume= 16 | issue= 4 | pages= 703-11 | pmid=7611026 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7611026 }} </ref> |
| | *Hyperintensity in mesiotemporal lobes<ref name="pmid19412521">{{cite journal| author=Jeong YM, Hwang HY, Kim HS| title=MRI of neurosyphilis presenting as mesiotemporal abnormalities: a case report. | journal=Korean J Radiol | year= 2009 | volume= 10 | issue= 3 | pages= 310-2 | pmid=19412521 | doi=10.3348/kjr.2009.10.3.310 | pmc=2672188 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19412521 }} </ref><ref name="pmid11264042">{{cite journal| author=Szilak I, Marty F, Helft J, Soeiro R| title=Neurosyphilis presenting as herpes simplex encephalitis. | journal=Clin Infect Dis | year= 2001 | volume= 32 | issue= 7 | pages= 1108-9 | pmid=11264042 | doi=10.1086/319598 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11264042 }} </ref> |
| | *Cortical [[atrophy]]<ref name="pmid17628376">{{cite journal| author=Peng F, Hu X, Zhong X, Wei Q, Jiang Y, Bao J et al.| title=CT and MR findings in HIV-negative neurosyphilis. | journal=Eur J Radiol | year= 2008 | volume= 66 | issue= 1 | pages= 1-6 | pmid=17628376 | doi=10.1016/j.ejrad.2007.05.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17628376 }} </ref> |
| | *[[Cerebral infarction]] |
| | *Hippocampal [[atrophy]] (mimicking [[alzheimer's disease]])<ref name="pmid22994551">{{cite journal| author=Mehrabian S, Raycheva M, Traykova M, Stankova T, Penev L, Grigorova O et al.| title=Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging. | journal=BMC Neurol | year= 2012 | volume= 12 | issue= | pages= 96 | pmid=22994551 | doi=10.1186/1471-2377-12-96 | pmc=3517431 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22994551 }} </ref> |
| | *Hyperintensities in multiple cortical areas and [[thalami]] <ref name="pmid23479472">{{cite journal| author=Agayeva N, Karli-Oguz K, Saka E| title=Teaching NeuroImages: a neurosyphilis case presenting with atypical neuroradiologic findings. | journal=Neurology | year= 2013 | volume= 80 | issue= 11 | pages= e119 | pmid=23479472 | doi=10.1212/WNL.0b013e318287280b | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23479472 }} </ref> |
| | *Intramedullary hyperintensity and spinal cord atrophy<ref name="pmid:22330117">{{cite journal| author=Pandey S| title=Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. | journal=J Spinal Cord Med | year= 2011 | volume= 34 | issue= 6 | pages= 609-11 | pmid=: 22330117 | doi=10.1179/2045772311Y.0000000041 | pmc=3237288 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22330117 }} </ref> |
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| *Longitudinal T2-weighted hyperintensity in the [[dorsal columns]] of the [[spinal cord]]<ref name="pmid19527360">{{cite journal| author=Bou-Haidar P, Peduto AJ, Karunaratne N| title=Differential diagnosis of T2 hyperintense spinal cord lesions: part B. | journal=J Med Imaging Radiat Oncol | year= 2009 | volume= 53 | issue= 2 | pages= 152-9 | pmid=19527360 | doi=10.1111/j.1754-9485.2009.02067.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19527360 }} </ref><ref name="pmid23956577">{{cite journal| author=Sen A, Chandrasekhar K| title=Spinal MR imaging in Vitamin B12 deficiency: Case series; differential diagnosis of symmetrical posterior spinal cord lesions. | journal=Ann Indian Acad Neurol | year= 2013 | volume= 16 | issue= 2 | pages= 255-8 | pmid=23956577 | doi=10.4103/0972-2327.112487 | pmc=3724087 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23956577 }} </ref> | | *Longitudinal T2-weighted hyperintensity in the [[dorsal columns]] of the [[spinal cord]]<ref name="pmid19527360">{{cite journal| author=Bou-Haidar P, Peduto AJ, Karunaratne N| title=Differential diagnosis of T2 hyperintense spinal cord lesions: part B. | journal=J Med Imaging Radiat Oncol | year= 2009 | volume= 53 | issue= 2 | pages= 152-9 | pmid=19527360 | doi=10.1111/j.1754-9485.2009.02067.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19527360 }} </ref><ref name="pmid23956577">{{cite journal| author=Sen A, Chandrasekhar K| title=Spinal MR imaging in Vitamin B12 deficiency: Case series; differential diagnosis of symmetrical posterior spinal cord lesions. | journal=Ann Indian Acad Neurol | year= 2013 | volume= 16 | issue= 2 | pages= 255-8 | pmid=23956577 | doi=10.4103/0972-2327.112487 | pmc=3724087 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23956577 }} </ref> |
| * Narrowing between the cervical [[Intervertebral disc|intervertebral discs]] and partial [[ankylosis]] of the cervical [[Intervertebral disc|disc]] space<ref name="pmid24436850">{{cite journal| author=Salem KM, Majeed H, Bommireddy R, Klezl Z| title=Tertiary syphilis in the cervical spine: a case report and review of the literature. | journal=Global Spine J | year= 2013 | volume= 3 | issue= 1 | pages= 41-6 | pmid=24436850 | doi=10.1055/s-0032-1329887 | pmc=3854603 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24436850 }} </ref> | | * Narrowing between the cervical [[Intervertebral disc|intervertebral discs]] and partial [[ankylosis]] of the cervical [[Intervertebral disc|disc]] space<ref name="pmid24436850">{{cite journal| author=Salem KM, Majeed H, Bommireddy R, Klezl Z| title=Tertiary syphilis in the cervical spine: a case report and review of the literature. | journal=Global Spine J | year= 2013 | volume= 3 | issue= 1 | pages= 41-6 | pmid=24436850 | doi=10.1055/s-0032-1329887 | pmc=3854603 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24436850 }} </ref> |
| *Bilateral high intensity signals on the T2 weighted sequence located in mesiotemporal, [[Insular cortex|insular]], [[Frontal lobe|frontal regions]]<ref name="pmid21440277">{{cite journal| author=Brisset M, Chadenat ML, Cordoliani Y, Kamga-Tallom R, D'Anglejean J, Pico F| title=[MRI features of neurosyphilis]. | journal=Rev Neurol (Paris) | year= 2011 | volume= 167 | issue= 4 | pages= 337-42 | pmid=21440277 | doi=10.1016/j.neurol.2010.08.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21440277 }} </ref> | | *Bilateral high intensity signals on the T2 weighted sequence located in mesiotemporal, [[Insular cortex|insular]], [[Frontal lobe|frontal regions]]<ref name="pmid21440277">{{cite journal| author=Brisset M, Chadenat ML, Cordoliani Y, Kamga-Tallom R, D'Anglejean J, Pico F| title=[MRI features of neurosyphilis]. | journal=Rev Neurol (Paris) | year= 2011 | volume= 167 | issue= 4 | pages= 337-42 | pmid=21440277 | doi=10.1016/j.neurol.2010.08.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21440277 }} </ref> |
| *[[Calcification]] of the [[ligamentum flavum]]<ref name="pmid24436850" /> | | *[[Calcification]] of the [[ligamentum flavum]]<ref name="pmid24436850" /><br> |
| ==References== | | ==References== |
| {{Reflist|2}} | | {{Reflist|2}} |
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| {{WH}} | | {{WH}} |
| {{WS}} | | {{WS}} |
| [[Category: (name of the system)]] | | [[Category: (name of the system)]] |
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| ==Overview==
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| MRI scan is not diagnostic of syphilis. However, non-specific MRI findings may demonstrate complications of syphilis including neurological, gastrointestinal, and bone findings.<ref name="pmid17628376">{{cite journal| author=Peng F, Hu X, Zhong X, Wei Q, Jiang Y, Bao J et al.| title=CT and MR findings in HIV-negative neurosyphilis. | journal=Eur J Radiol | year= 2008 | volume= 66 | issue= 1 | pages= 1-6 | pmid=17628376 | doi=10.1016/j.ejrad.2007.05.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17628376 }} </ref><ref name="pmid7611026">{{cite journal| author=Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA| title=Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. | journal=AJNR Am J Neuroradiol | year= 1995 | volume= 16 | issue= 4 | pages= 703-11 | pmid=7611026 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7611026 }} </ref><ref name="pmid22994551">{{cite journal| author=Mehrabian S, Raycheva M, Traykova M, Stankova T, Penev L, Grigorova O et al.| title=Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging. | journal=BMC Neurol | year= 2012 | volume= 12 | issue= | pages= 96 | pmid=22994551 | doi=10.1186/1471-2377-12-96 | pmc=3517431 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22994551 }} </ref><ref name="pmid19412521">{{cite journal| author=Jeong YM, Hwang HY, Kim HS| title=MRI of neurosyphilis presenting as mesiotemporal abnormalities: a case report. | journal=Korean J Radiol | year= 2009 | volume= 10 | issue= 3 | pages= 310-2 | pmid=19412521 | doi=10.3348/kjr.2009.10.3.310 | pmc=2672188 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19412521 }} </ref><ref name="pmid11264042">{{cite journal| author=Szilak I, Marty F, Helft J, Soeiro R| title=Neurosyphilis presenting as herpes simplex encephalitis. | journal=Clin Infect Dis | year= 2001 | volume= 32 | issue= 7 | pages= 1108-9 | pmid=11264042 | doi=10.1086/319598 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11264042 }} </ref><ref name="pmid11156776">{{cite journal| author=Bash S, Hathout GM, Cohen S| title=Mesiotemporal T2-weighted hyperintensity: neurosyphilis mimicking herpes encephalitis. | journal=AJNR Am J Neuroradiol | year= 2001 | volume= 22 | issue= 2 | pages= 314-6 | pmid=11156776 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11156776 }} </ref><ref name="pmid23479472">{{cite journal| author=Agayeva N, Karli-Oguz K, Saka E| title=Teaching NeuroImages: a neurosyphilis case presenting with atypical neuroradiologic findings. | journal=Neurology | year= 2013 | volume= 80 | issue= 11 | pages= e119 | pmid=23479472 | doi=10.1212/WNL.0b013e318287280b | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23479472 }} </ref><ref name="pmid24261864">{{cite journal| author=Khamaysi Z, Bergman R, Telman G, Goldsher D| title=Clinical and imaging findings in patients with neurosyphilis: a study of a cohort and review of the literature. | journal=Int J Dermatol | year= 2014 | volume= 53 | issue= 7 | pages= 812-9 | pmid=24261864 | doi=10.1111/ijd.12095 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24261864 }} </ref><ref name="pmid: 22330117">{{cite journal| author=Pandey S| title=Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. | journal=J Spinal Cord Med | year= 2011 | volume= 34 | issue= 6 | pages= 609-11 | pmid=: 22330117 | doi=10.1179/2045772311Y.0000000041 | pmc=3237288 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22330117 }} </ref><ref name="pmid17297001">{{cite journal| author=Huang I, Leach JL, Fichtenbaum CJ, Narayan RK| title=Osteomyelitis of the skull in early-acquired syphilis: evaluation by MR imaging and CT. | journal=AJNR Am J Neuroradiol | year= 2007 | volume= 28 | issue= 2 | pages= 307-8 | pmid=17297001 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17297001 }} </ref><ref name="pmid20191023">{{cite journal| author=Cha JM, Choi SI, Lee JI| title=Rectal syphilis mimicking rectal cancer. | journal=Yonsei Med J | year= 2010 | volume= 51 | issue= 2 | pages= 276-8 | pmid=20191023 | doi=10.3349/ymj.2010.51.2.276 | pmc=2824876 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20191023 }} </ref><ref name="pmid:22330117">{{cite journal| author=Pandey S| title=Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. | journal=J Spinal Cord Med | year= 2011 | volume= 34 | issue= 6 | pages= 609-11 | pmid=: 22330117 | doi=10.1179/2045772311Y.0000000041 | pmc=3237288 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22330117 }} </ref>
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| ==MRI==
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| MRI scan is not diagnostic of syphilis. However, non-specific MRI findings may demonstrate complications of syphilis including neurological, gastrointestinal, and bone findings:<ref name="pmid17628376">{{cite journal| author=Peng F, Hu X, Zhong X, Wei Q, Jiang Y, Bao J et al.| title=CT and MR findings in HIV-negative neurosyphilis. | journal=Eur J Radiol | year= 2008 | volume= 66 | issue= 1 | pages= 1-6 | pmid=17628376 | doi=10.1016/j.ejrad.2007.05.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17628376 }} </ref><ref name="pmid7611026">{{cite journal| author=Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA| title=Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. | journal=AJNR Am J Neuroradiol | year= 1995 | volume= 16 | issue= 4 | pages= 703-11 | pmid=7611026 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7611026 }} </ref><ref name="pmid22994551">{{cite journal| author=Mehrabian S, Raycheva M, Traykova M, Stankova T, Penev L, Grigorova O et al.| title=Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging. | journal=BMC Neurol | year= 2012 | volume= 12 | issue= | pages= 96 | pmid=22994551 | doi=10.1186/1471-2377-12-96 | pmc=3517431 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22994551 }} </ref><ref name="pmid19412521">{{cite journal| author=Jeong YM, Hwang HY, Kim HS| title=MRI of neurosyphilis presenting as mesiotemporal abnormalities: a case report. | journal=Korean J Radiol | year= 2009 | volume= 10 | issue= 3 | pages= 310-2 | pmid=19412521 | doi=10.3348/kjr.2009.10.3.310 | pmc=2672188 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19412521 }} </ref><ref name="pmid11264042">{{cite journal| author=Szilak I, Marty F, Helft J, Soeiro R| title=Neurosyphilis presenting as herpes simplex encephalitis. | journal=Clin Infect Dis | year= 2001 | volume= 32 | issue= 7 | pages= 1108-9 | pmid=11264042 | doi=10.1086/319598 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11264042 }} </ref><ref name="pmid11156776">{{cite journal| author=Bash S, Hathout GM, Cohen S| title=Mesiotemporal T2-weighted hyperintensity: neurosyphilis mimicking herpes encephalitis. | journal=AJNR Am J Neuroradiol | year= 2001 | volume= 22 | issue= 2 | pages= 314-6 | pmid=11156776 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11156776 }} </ref><ref name="pmid23479472">{{cite journal| author=Agayeva N, Karli-Oguz K, Saka E| title=Teaching NeuroImages: a neurosyphilis case presenting with atypical neuroradiologic findings. | journal=Neurology | year= 2013 | volume= 80 | issue= 11 | pages= e119 | pmid=23479472 | doi=10.1212/WNL.0b013e318287280b | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23479472 }} </ref><ref name="pmid24261864">{{cite journal| author=Khamaysi Z, Bergman R, Telman G, Goldsher D| title=Clinical and imaging findings in patients with neurosyphilis: a study of a cohort and review of the literature. | journal=Int J Dermatol | year= 2014 | volume= 53 | issue= 7 | pages= 812-9 | pmid=24261864 | doi=10.1111/ijd.12095 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24261864 }} </ref><ref name="pmid: 22330117">{{cite journal| author=Pandey S| title=Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. | journal=J Spinal Cord Med | year= 2011 | volume= 34 | issue= 6 | pages= 609-11 | pmid=: 22330117 | doi=10.1179/2045772311Y.0000000041 | pmc=3237288 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22330117 }} </ref><ref name="pmid17297001">{{cite journal| author=Huang I, Leach JL, Fichtenbaum CJ, Narayan RK| title=Osteomyelitis of the skull in early-acquired syphilis: evaluation by MR imaging and CT. | journal=AJNR Am J Neuroradiol | year= 2007 | volume= 28 | issue= 2 | pages= 307-8 | pmid=17297001 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17297001 }} </ref><ref name="pmid20191023">{{cite journal| author=Cha JM, Choi SI, Lee JI| title=Rectal syphilis mimicking rectal cancer. | journal=Yonsei Med J | year= 2010 | volume= 51 | issue= 2 | pages= 276-8 | pmid=20191023 | doi=10.3349/ymj.2010.51.2.276 | pmc=2824876 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20191023 }} </ref>
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| ===Neurosyphilis===
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| MRI may help diagnose complications of syphilis such as neurosyphilis. High intensity T2 MRI brain and spinal cord may indicate the following findings:<ref name="pmid17628376">{{cite journal| author=Peng F, Hu X, Zhong X, Wei Q, Jiang Y, Bao J et al.| title=CT and MR findings in HIV-negative neurosyphilis. | journal=Eur J Radiol | year= 2008 | volume= 66 | issue= 1 | pages= 1-6 | pmid=17628376 | doi=10.1016/j.ejrad.2007.05.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17628376 }} </ref><ref name="pmid7611026">{{cite journal| author=Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA| title=Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. | journal=AJNR Am J Neuroradiol | year= 1995 | volume= 16 | issue= 4 | pages= 703-11 | pmid=7611026 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7611026 }} </ref><ref name="pmid22994551">{{cite journal| author=Mehrabian S, Raycheva M, Traykova M, Stankova T, Penev L, Grigorova O et al.| title=Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging. | journal=BMC Neurol | year= 2012 | volume= 12 | issue= | pages= 96 | pmid=22994551 | doi=10.1186/1471-2377-12-96 | pmc=3517431 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22994551 }} </ref><ref name="pmid19412521">{{cite journal| author=Jeong YM, Hwang HY, Kim HS| title=MRI of neurosyphilis presenting as mesiotemporal abnormalities: a case report. | journal=Korean J Radiol | year= 2009 | volume= 10 | issue= 3 | pages= 310-2 | pmid=19412521 | doi=10.3348/kjr.2009.10.3.310 | pmc=2672188 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19412521 }} </ref><ref name="pmid: 22330117">{{cite journal| author=Pandey S| title=Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. | journal=J Spinal Cord Med | year= 2011 | volume= 34 | issue= 6 | pages= 609-11 | pmid=: 22330117 | doi=10.1179/2045772311Y.0000000041 | pmc=3237288 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22330117 }} </ref>
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| *Non specific [[white matter]] lesions (cerebral gummas or [[arteritis]])<ref name="pmid7611026">{{cite journal| author=Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA| title=Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. | journal=AJNR Am J Neuroradiol | year= 1995 | volume= 16 | issue= 4 | pages= 703-11 | pmid=7611026 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7611026 }} </ref>
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| *Hyperintensity in mesiotemporal lobes<ref name="pmid19412521">{{cite journal| author=Jeong YM, Hwang HY, Kim HS| title=MRI of neurosyphilis presenting as mesiotemporal abnormalities: a case report. | journal=Korean J Radiol | year= 2009 | volume= 10 | issue= 3 | pages= 310-2 | pmid=19412521 | doi=10.3348/kjr.2009.10.3.310 | pmc=2672188 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19412521 }} </ref><ref name="pmid11264042">{{cite journal| author=Szilak I, Marty F, Helft J, Soeiro R| title=Neurosyphilis presenting as herpes simplex encephalitis. | journal=Clin Infect Dis | year= 2001 | volume= 32 | issue= 7 | pages= 1108-9 | pmid=11264042 | doi=10.1086/319598 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11264042 }} </ref>
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| *Cortical [[atrophy]] (general [[paresis]])<ref name="pmid17628376">{{cite journal| author=Peng F, Hu X, Zhong X, Wei Q, Jiang Y, Bao J et al.| title=CT and MR findings in HIV-negative neurosyphilis. | journal=Eur J Radiol | year= 2008 | volume= 66 | issue= 1 | pages= 1-6 | pmid=17628376 | doi=10.1016/j.ejrad.2007.05.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17628376 }} </ref>
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| *[[Cerebral infarction]]
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| *Hippocampal [[atrophy]] (mimicking [[alzheimer's disease]])<ref name="pmid22994551">{{cite journal| author=Mehrabian S, Raycheva M, Traykova M, Stankova T, Penev L, Grigorova O et al.| title=Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging. | journal=BMC Neurol | year= 2012 | volume= 12 | issue= | pages= 96 | pmid=22994551 | doi=10.1186/1471-2377-12-96 | pmc=3517431 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22994551 }} </ref>
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| *Hyperintensities in multiple cortical areas and [[thalami]] <ref name="pmid23479472">{{cite journal| author=Agayeva N, Karli-Oguz K, Saka E| title=Teaching NeuroImages: a neurosyphilis case presenting with atypical neuroradiologic findings. | journal=Neurology | year= 2013 | volume= 80 | issue= 11 | pages= e119 | pmid=23479472 | doi=10.1212/WNL.0b013e318287280b | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23479472 }} </ref>
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| *Intramedullary hyperintensity and spinal cord atrophy<ref name="pmid:22330117">{{cite journal| author=Pandey S| title=Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. | journal=J Spinal Cord Med | year= 2011 | volume= 34 | issue= 6 | pages= 609-11 | pmid=: 22330117 | doi=10.1179/2045772311Y.0000000041 | pmc=3237288 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22330117 }} </ref>
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| ===Bone===
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| *Small [[Tibia|tibial]] and [[Fibula|fibular]] nodular hyperintense lesions<ref name="pmid19795120">{{cite journal| author=Naraghi AM, Salonen DC, Bloom JA, Becker EJ| title=Magnetic resonance imaging features of osseous manifestations of early acquired syphilis. | journal=Skeletal Radiol | year= 2010 | volume= 39 | issue= 3 | pages= 305-9 | pmid=19795120 | doi=10.1007/s00256-009-0806-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19795120 }} </ref>
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| ===Skull===
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| *T2W lesions in the skull showing hyperintensity<ref name="pmid17297001">{{cite journal| author=Huang I, Leach JL, Fichtenbaum CJ, Narayan RK| title=Osteomyelitis of the skull in early-acquired syphilis: evaluation by MR imaging and CT. | journal=AJNR Am J Neuroradiol | year= 2007 | volume= 28 | issue= 2 | pages= 307-8 | pmid=17297001 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17297001 }} </ref>
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| ===Rectal===
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| *T2W MRI images showing hyperintense thickening of rectal wall (mimicking [[rectal cancer]])<ref name="pmid20191023">{{cite journal| author=Cha JM, Choi SI, Lee JI| title=Rectal syphilis mimicking rectal cancer. | journal=Yonsei Med J | year= 2010 | volume= 51 | issue= 2 | pages= 276-8 | pmid=20191023 | doi=10.3349/ymj.2010.51.2.276 | pmc=2824876 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20191023 }} </ref>
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