Other imaging findings of syphilis include novel PET/CT technology, multimodal ophthalmologic imaging, bone [[scintigraphy]], and [[angiography]]. PET/CT is a novel imaging study which portrays 18F-[[Fluorodeoxyglucose]] (FDG) uptake enhanced regions superimposed on cross sectional CT images. Multimodal ophthalmologic imaging combines ophthalmoscopy with spectral domain optical coherence tomography (SD-OCT) to produce high definition imaging of the posterior chamber of the eye. Bone scintigraphy allows clinicians to visualize bone uptake of Technetium-99 (T-99m) using x-ray technology. These imaging findings allow clinicians to detect syphilitic manifestations involving the bone, retina, heart, lungs, and lymph nodes.<ref name="pmid21637078">{{cite journal| author=Wang X, Yin J, Chen X| title=Syphilitic bone destruction on FDG PET/CT. | journal=Clin Nucl Med | year= 2011 | volume= 36 | issue= 7 | pages= 616-8 | pmid=21637078 | doi=10.1097/RLU.0b013e318219ac62 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21637078 }} </ref><ref name="pmid21431031">{{cite journal| author=Kim HJ, Seon HJ, Shin HH, Choi YD| title=Case report: Pulmonary syphilis mimicking pulmonary hematogenous metastases on chest CT and integrated PET/CT. | journal=Indian J Radiol Imaging | year= 2011 | volume= 21 | issue= 1 | pages= 34-7 | pmid=21431031 | doi=10.4103/0971-3026.76052 | pmc=3056368 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21431031 }} </ref><ref name="pmid21431031">{{cite journal| author=Kim HJ, Seon HJ, Shin HH, Choi YD| title=Case report: Pulmonary syphilis mimicking pulmonary hematogenous metastases on chest CT and integrated PET/CT. | journal=Indian J Radiol Imaging | year= 2011 | volume= 21 | issue= 1 | pages= 34-7 | pmid=21431031 | doi=10.4103/0971-3026.76052 | pmc=3056368 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21431031 }} </ref><ref name="pmid26929943">{{cite journal| author=Kim JM, Lee SM, Bae SB, Lee JS, Kim SY| title=The role of PET/CT in diagnosing generalized lymphadenopathy in asymptomatic secondary syphilis. | journal=Hell J Nucl Med | year= 2016 | volume= 19 | issue= 1 | pages= 60-2 | pmid=26929943 | doi=10.1967/s002449910340 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26929943 }} </ref><ref name="pmid19795120">{{cite journal| author=Naraghi AM, Salonen DC, Bloom JA, Becker EJ| title=Magnetic resonance imaging features of osseous manifestations of early acquired syphilis. | journal=Skeletal Radiol | year= 2010 | volume= 39 | issue= 3 | pages= 305-9 | pmid=19795120 | doi=10.1007/s00256-009-0806-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19795120 }} </ref><ref name="pmid26237137">{{cite journal| author=Curi AL, Sarraf D, Cunningham ET| title=MULTIMODAL IMAGING OF SYPHILITIC MULTIFOCAL RETINITIS. | journal=Retin Cases Brief Rep | year= 2015 | volume= 9 | issue= 4 | pages= 277-80 | pmid=26237137 | doi=10.1097/ICB.0000000000000186 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26237137 }} </ref><ref name="pmid25980046">{{cite journal| author=Sekine Y, Yashiro S, O'hira A, Yoshida N, Morinaga M, Nagashima N et al.| title=[Multimodal imaging of a case of acute syphilitic posterior placoid chorioretinitis]. | journal=Nippon Ganka Gakkai Zasshi | year= 2015 | volume= 119 | issue= 4 | pages= 266-72 | pmid=25980046 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25980046 }} </ref>
Other imaging findings of neurosyphilis include novel PET/CT technology, multimodal ophthalmologic imaging and bone [[scintigraphy]]. In PET/CT scan, increased FDG uptake in lymph nodes may be seen. Multimodal ophthalmologic imaging combines ophthalmoscopy with spectral domain optical coherence tomography (SD-OCT) to produce high definition imaging of the posterior chamber of the eye. Bone scintigraphy allows clinicians to visualize bone uptake of Technetium-99 (T-99m) using x-ray technology.
==Other imaging studies==
==Other imaging studies==
Other imaging findings of syphilis include novel PET/CT technology, multimodal ophthalmologic imaging, bone [[scintigraphy]], and [[angiography]]. These imaging findings allow clinicians to detect syphilitic manifestations involving the bone, retina, heart, lungs, and lymph nodes.
Other imaging findings of neurosyphilis include novel PET/CT technology, multimodal ophthalmologic imaging and bone [[scintigraphy]].
===PET/CT (FDG Uptake)===
===PET/CT (FDG Uptake)===
:'''Bone'''
* Increased FDG uptake in lymph nodes is seen.<ref name="pmid26929943">{{cite journal| author=Kim JM, Lee SM, Bae SB, Lee JS, Kim SY| title=The role of PET/CT in diagnosing generalized lymphadenopathy in asymptomatic secondary syphilis. | journal=Hell J Nucl Med | year= 2016 | volume= 19 | issue= 1 | pages= 60-2 | pmid=26929943 | doi=10.1967/s002449910340 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26929943 }} </ref>
Other imaging findings of neurosyphilis include novel PET/CT technology, multimodal ophthalmologic imaging and bone scintigraphy. In PET/CT scan, increased FDG uptake in lymph nodes may be seen. Multimodal ophthalmologic imaging combines ophthalmoscopy with spectral domain optical coherence tomography (SD-OCT) to produce high definition imaging of the posterior chamber of the eye. Bone scintigraphy allows clinicians to visualize bone uptake of Technetium-99 (T-99m) using x-ray technology.
Other imaging studies
Other imaging findings of neurosyphilis include novel PET/CT technology, multimodal ophthalmologic imaging and bone scintigraphy.