Adult-onset Still's disease laboratory findings

Adult-onset Still's disease
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Adult-onset Still’s Disease from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Template:Adult-onset Still's disease On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Template:Adult-onset Still's disease All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Adult-onset Still's disease laboratory findings
CDC on Template:Adult-onset Still's disease
Template:Adult-onset Still's disease in the news
Blogs on Template:Adult-onset Still's disease
Risk calculators and risk factors for Template:Adult-onset Still's disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]

Overview

Adult-onset Still's disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, inflammatory marker such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) may be elevated. Complete blood count may show leukocytosis with a left shift (increased neutrophils), anemia, thrombocytosis or pancytopenia (in cases of hemophagocytic syndrome).

Laboratory Findings

Adult-onset Still's disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, the following laboratory abnormalities may be observed:

Inflammatory markers

• Increased ferritin (greater than 5 times of upper limit of normal may aid in diagnosis- > 1000 ng/ml)
• Elevated ESR
• Elevated CRP

Complete blood count

• Leukocytosis with pre-dominant neutrophils (left shift)
• Anemia
• Thrombocytosis
• Pancytopenia (in case of hemophagocytic syndrome)

Partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT)

• Increased in case of disseminated intravascular coagulation (DIC)

Liver function tests (LFTs)

• Increased lactic dehydrogenase
• Increased aspartate aminotransferase (AST), and alanine aminotransferase (ALT)
• Increased γ‐glutamyltransferase
• Increased bilirubin