Polyarteritis nodosa laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
There are no specific lab tests for diagnosing polyarteritis nodosa. Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis. Laboratory findings helpful in the diagnosis of polyarteritis nodosa include [[Complete blood count|CBC]], ESR, C-reactive protein, [[Anti-neutrophil cytoplasmic antibody|p-ANCA]], [[Hepatitis B surface antigen]] and hepatitic C serologies, elevated levels of liver enzymes, elevated [[creatinine]] level and [[hypergammaglobulinemia]]. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
There are no specific lab tests for diagnosing polyarteritis nodosa. Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis | * There are no specific lab tests for diagnosing polyarteritis nodosa. | ||
* Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis. | |||
* Laboratory findings consistent with the diagnosis of polyarteritis nodosa include | |||
* [[Complete blood count|CBC]] | ** [[Complete blood count|CBC]] may show: | ||
* [[Erythrocyte sedimentation rate|ESR]] | *** Leukocytosis | ||
* Perinuclear pattern of [[antineutrophil cytoplasmic antibodies]] ([[p-ANCA]]) - not associated with "classic" polyarteritis nodosa, but is present in a form of the disease affecting smaller blood vessels, known as [[microscopic polyangiitis]] or leukocytoclastic angiitis. | *** Normochromic anemia | ||
* Elevated | *** thrombocytosis | ||
** [[Erythrocyte sedimentation rate|ESR]] and [[C-reactive protein]]<ref name="pmid12350194">{{cite journal |vauthors=Stone JH |title=Polyarteritis nodosa |journal=JAMA |volume=288 |issue=13 |pages=1632–9 |date=October 2002 |pmid=12350194 |doi= |url=}}</ref> | |||
*** These can be helpful to diagnose active disease. | |||
** Perinuclear pattern of [[antineutrophil cytoplasmic antibodies]] ([[p-ANCA]]) - not associated with "classic" polyarteritis nodosa, but is present in a form of the disease affecting smaller blood vessels, known as [[microscopic polyangiitis]] or leukocytoclastic angiitis. | |||
** Hepatitis B surface antigen and hepatitic C serologies | |||
*** Patients with HBV related polyarteritis nodosa show: | |||
**** Decreased levels of serum C3 and C4. | |||
**** Circulating immune complexes | |||
**** Cryoglobulins | |||
** Elevated levels of liver enzymes | |||
** Elevated creatinine level | |||
** Hypergammaglobulinemia | |||
*** Seen in 30% patients with polyarteritis nodosa. | |||
==References== | ==References== | ||
Latest revision as of 18:12, 21 May 2018
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Polyarteritis nodosa Microchapters |
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Polyarteritis nodosa laboratory findings On the Web |
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Risk calculators and risk factors for Polyarteritis nodosa laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Haritha Machavarapu, M.B.B.S.
Overview
There are no specific lab tests for diagnosing polyarteritis nodosa. Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis. Laboratory findings helpful in the diagnosis of polyarteritis nodosa include CBC, ESR, C-reactive protein, p-ANCA, Hepatitis B surface antigen and hepatitic C serologies, elevated levels of liver enzymes, elevated creatinine level and hypergammaglobulinemia.
Laboratory Findings
- There are no specific lab tests for diagnosing polyarteritis nodosa.
- Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis.
- Laboratory findings consistent with the diagnosis of polyarteritis nodosa include
- CBC may show:
- Leukocytosis
- Normochromic anemia
- thrombocytosis
- ESR and C-reactive protein[1]
- These can be helpful to diagnose active disease.
- Perinuclear pattern of antineutrophil cytoplasmic antibodies (p-ANCA) - not associated with "classic" polyarteritis nodosa, but is present in a form of the disease affecting smaller blood vessels, known as microscopic polyangiitis or leukocytoclastic angiitis.
- Hepatitis B surface antigen and hepatitic C serologies
- Patients with HBV related polyarteritis nodosa show:
- Decreased levels of serum C3 and C4.
- Circulating immune complexes
- Cryoglobulins
- Patients with HBV related polyarteritis nodosa show:
- Elevated levels of liver enzymes
- Elevated creatinine level
- Hypergammaglobulinemia
- Seen in 30% patients with polyarteritis nodosa.
- CBC may show: