Takayasu's arteritis natural history, complications and prognosis: Difference between revisions
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{{Takayasu's arteritis}} | {{Takayasu's arteritis}} | ||
{{CMG}} {{AE}} {{FKH}} | {{CMG}} {{AE}} {{FKH}} | ||
==Overview== | ==Overview== | ||
| Line 10: | Line 8: | ||
==Natural History== | ==Natural History== | ||
===Natural History=== | ===Natural History=== | ||
* The symptoms of Takayasu's arteritis typically develop between 15 and 30 years of age.<ref name="pmid19026150" /> | * The [[symptoms]] of Takayasu's arteritis typically develop between 15 and 30 years of age.<ref name="pmid19026150" /> | ||
* If left untreated, patients with Takayasu's arteritis may progress to develop [[high blood pressure]], [[stroke]] or [[heart failure]]. | * If left untreated, patients with Takayasu's arteritis may progress to develop [[high blood pressure]], [[stroke]], or [[heart failure]]. | ||
* Takayasu's arteritis can be divided into two phases:<ref name="pmid7909656">{{cite journal |vauthors=Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, Hoffman GS |title=Takayasu arteritis |journal=Ann. Intern. Med. |volume=120 |issue=11 |pages=919–29 |date=June 1994 |pmid=7909656 |doi= |url=}}</ref><ref name="pmid20596053">{{cite journal |vauthors=Mason JC |title=Takayasu arteritis--advances in diagnosis and management |journal=Nat Rev Rheumatol |volume=6 |issue=7 |pages=406–15 |date=July 2010 |pmid=20596053 |doi=10.1038/nrrheum.2010.82 |url=}}</ref> | |||
**Pre-pulseless phase | |||
***Present with non-specific constitutional symptoms of [[vasculitis]] such as: | |||
****[[Fatigue]] | |||
****[[Fever of unknown origin]] | |||
****[[Weight loss]] | |||
****[[Myalgia]] | |||
****[[Arthralgia]] | |||
**Subsequent pulseless phase | |||
***Present with involvement of the branches of [[aorta]] and specific [[Symptom|symptoms]] secondary to occlusion of the branches of [[aorta]] such as: | |||
****[[Subclavian artery]]: | |||
*****[[Claudication]] in the [[upper extremities]] | |||
*****[[Subclavian steal syndrome]] | |||
****[[Carotid arteries|Carotid]] and [[Vertebral artery|vertebral arteries]]: | |||
*****[[Headache]] | |||
*****[[Vertigo]] | |||
*****[[Syncope]] | |||
*****[[Convulsions]] | |||
*****[[Amnesia|Forgetfulness]] | |||
****[[Coronary arteries]]: | |||
*****[[Chest pain]] | |||
****[[Ascending aorta]]: | |||
*****[[Aortic regurgitation]] | |||
===Complications=== | ===Complications=== | ||
| Line 17: | Line 39: | ||
*Hardening and narrowing of [[blood vessels]] | *Hardening and narrowing of [[blood vessels]] | ||
*[[High blood pressure]] | *[[High blood pressure]] | ||
* | *[[Carditis]] | ||
*[[Heart failure]] | *[[Heart failure]] | ||
*[[Stroke]] | *[[Stroke]] | ||
| Line 25: | Line 47: | ||
===Prognosis=== | ===Prognosis=== | ||
* Takayasu arteritis is a chronic relapsing and remitting | * Takayasu arteritis is a chronic relapsing and remitting disease.<ref name="pmid16195161">{{cite journal |vauthors=Park MC, Lee SW, Park YB, Chung NS, Lee SK |title=Clinical characteristics and outcomes of Takayasu's arteritis: analysis of 108 patients using standardized criteria for diagnosis, activity assessment, and angiographic classification |journal=Scand. J. Rheumatol. |volume=34 |issue=4 |pages=284–92 |date=2005 |pmid=16195161 |doi=10.1080/03009740510026526 |url=}}</ref> | ||
* Takayasu arteritis is associated with significant [[morbidity]]. | * Takayasu arteritis is associated with significant [[morbidity]]. | ||
* The [[five year survival rate]] in Takayasu arteritis is over 90%. | * The [[five year survival rate]] in patients suffering from Takayasu arteritis is over 90%. | ||
==References== | ==References== | ||
Latest revision as of 13:26, 24 May 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farnaz Khalighinejad, MD [2]
Overview
The symptoms of Takayasu's arteritis typically develop between 15 and 30 years of age. Common complications of Takayasu's arteritis include hardening and narrowing of blood vessels, High blood pressure, Heart failure, Stroke, Transient ischemic attack. The five year survival rate in Takayasu arteritis is over 90%.
Natural History
Natural History
- The symptoms of Takayasu's arteritis typically develop between 15 and 30 years of age.[1]
- If left untreated, patients with Takayasu's arteritis may progress to develop high blood pressure, stroke, or heart failure.
- Takayasu's arteritis can be divided into two phases:[2][3]
- Pre-pulseless phase
- Present with non-specific constitutional symptoms of vasculitis such as:
- Pre-pulseless phase
Complications
Common complications of Takayasu's arteritis include:[1]
- Hardening and narrowing of blood vessels
- High blood pressure
- Carditis
- Heart failure
- Stroke
- Transient ischemic attack (TIA)
- Aneurysm in the aorta
- Heart attack
Prognosis
- Takayasu arteritis is a chronic relapsing and remitting disease.[4]
- Takayasu arteritis is associated with significant morbidity.
- The five year survival rate in patients suffering from Takayasu arteritis is over 90%.
References
- ↑ 1.0 1.1 Phillip R, Luqmani R (2008). "Mortality in systemic vasculitis: a systematic review". Clin. Exp. Rheumatol. 26 (5 Suppl 51): S94–104. PMID 19026150.
- ↑ Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, Hoffman GS (June 1994). "Takayasu arteritis". Ann. Intern. Med. 120 (11): 919–29. PMID 7909656.
- ↑ Mason JC (July 2010). "Takayasu arteritis--advances in diagnosis and management". Nat Rev Rheumatol. 6 (7): 406–15. doi:10.1038/nrrheum.2010.82. PMID 20596053.
- ↑ Park MC, Lee SW, Park YB, Chung NS, Lee SK (2005). "Clinical characteristics and outcomes of Takayasu's arteritis: analysis of 108 patients using standardized criteria for diagnosis, activity assessment, and angiographic classification". Scand. J. Rheumatol. 34 (4): 284–92. doi:10.1080/03009740510026526. PMID 16195161.