Diffuse large B cell lymphoma laboratory tests: Difference between revisions
No edit summary |
No edit summary |
||
| (15 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Diffuse large B cell lymphoma}} | {{Diffuse large B cell lymphoma}} | ||
{{CMG}}; {{AE}} {{AS}} {{AHS}} | |||
== Overview == | |||
Diagnostic Work up for Diffuse Large B cell Lymphoma include Laboratory tests including [[Complete Blood count (CBC)]], Comprehensive [[Metabolic Panel]], [[LDH]] and [[Uric acid]] Levels, [[Genetic]] testing, [[molecular]] diagnostic assays and immunophenotyping. Screening tests for [[Hepatitis B]], [[Hepatitis C]] and [[Human Immunodeficiency Virus (HIV)|HIV]] are usually recommended after diagnosis. | |||
== Laboratory tests == | |||
__NOTOC__ | |||
{{Diffuse large B cell lymphoma}} | |||
DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays. | |||
Laboratory tests of diffuse large B cell lymphoma include:<ref name="”seer”">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref> | |||
* [[Complete blood count]] (CBC) | |||
* [[Comprehensive metabolic panel]] | |||
* Blood chemistry studies including [[Lactate dehydrogenase|LDH]] and [[Uric acid]] | |||
* [[Immunohistochemistry]](IHC) | |||
** CD20, CD3, CD5, CD45, CD10, BCL-2, BCl-6, MYC, IRF-4/ MUM-1, Ki-67 | |||
* [[Flow Cytometry|Flow Cytometry Panel]] (Establishing Reliable Diagnosis require IHC with or without Flow cytometry) | |||
** Kappa/ Lambda, CD3, CD5, CD45, CD10, CD19, CD20 | |||
* IHC for DLBCL subtypes: | |||
** Kappa/ Lambda, CD30, CD138, Cyclin/D1, ALK, HHV-8, SOX-11, EBER-ISH | |||
* [[Cytology]] (for primary CNS lymphoma only) | |||
* [[Genetic testing]] | |||
** 8q24/''MYC'' [[translocations]] | |||
** Immunoglobulin genes clonally rearranged and hypermutated | |||
** Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]''/''TTFn'', ''[[TP53]]'' genes | |||
** Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes | |||
* Screening tests for HCV and HBV ( to assess risk of Reactivation following immunotherapy/ chemotherapy) are recommended. | |||
* Screening test for HIV | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
| Line 13: | Line 39: | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Hematology]] | |||
[[Category:Immunology]] | |||
Latest revision as of 22:39, 23 July 2018
|
Diffuse large B cell lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Diffuse large B cell lymphoma laboratory tests On the Web |
|
American Roentgen Ray Society Images of Diffuse large B cell lymphoma laboratory tests |
|
Directions to Hospitals Treating Diffuse large B cell lymphoma |
|
Risk calculators and risk factors for Diffuse large B cell lymphoma laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Anila Hussain, MD [3]
Overview
Diagnostic Work up for Diffuse Large B cell Lymphoma include Laboratory tests including Complete Blood count (CBC), Comprehensive Metabolic Panel, LDH and Uric acid Levels, Genetic testing, molecular diagnostic assays and immunophenotyping. Screening tests for Hepatitis B, Hepatitis C and HIV are usually recommended after diagnosis.
Laboratory tests
|
Diffuse large B cell lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Diffuse large B cell lymphoma laboratory tests On the Web |
|
American Roentgen Ray Society Images of Diffuse large B cell lymphoma laboratory tests |
|
Directions to Hospitals Treating Diffuse large B cell lymphoma |
|
Risk calculators and risk factors for Diffuse large B cell lymphoma laboratory tests |
DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays.
Laboratory tests of diffuse large B cell lymphoma include:[1]
- Complete blood count (CBC)
- Comprehensive metabolic panel
- Blood chemistry studies including LDH and Uric acid
- Immunohistochemistry(IHC)
- CD20, CD3, CD5, CD45, CD10, BCL-2, BCl-6, MYC, IRF-4/ MUM-1, Ki-67
- Flow Cytometry Panel (Establishing Reliable Diagnosis require IHC with or without Flow cytometry)
- Kappa/ Lambda, CD3, CD5, CD45, CD10, CD19, CD20
- IHC for DLBCL subtypes:
- Kappa/ Lambda, CD30, CD138, Cyclin/D1, ALK, HHV-8, SOX-11, EBER-ISH
- Cytology (for primary CNS lymphoma only)
- Genetic testing
- Screening tests for HCV and HBV ( to assess risk of Reactivation following immunotherapy/ chemotherapy) are recommended.
- Screening test for HIV
References
- ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov