Plummer-Vinson syndrome: Difference between revisions

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'''For patient information, click [[Plummer-Vinson syndrome (patient information)|here]].'''
{{Plummer-Vinson syndrome}}
{{Plummer-Vinson syndrome}}
{{CMG}}
{{CMG}}; {{AE}}{{Akshun}}
__NOTOC__
__NOTOC__
{{SK}} Paterson-Brown-Kelly syndrome; sideropenic dysphagia
{{SK}} Paterson-Brown-Kelly syndrome; Plummer-Vinson-Patterson-Kelly syndrome; Paterson-Kelly syndrome; sideropenic dysphagia; chronic pharyngo-oesophagitis
 


==[[Plummer-Vinson syndrome overview|Overview]]==


==[[Plummer-Vinson syndrome historical perspective|Historical Perspective]]==


==Causes and associated conditions==
==[[Plummer-Vinson syndrome classification|Classification]]==
The cause of Plummer-Vinson syndrome is unknown; however, [[Genetics|genetic]] factors and [[nutrition|nutritional deficiencies]] may play a role.


Women are at higher risk than men, particularly in middle age. In these patients, esophageal [[squamous cell carcinoma]] risk is increased; therefore, it is considered a premalignant process.
==[[Plummer-Vinson syndrome pathophysiology|Pathophysiology]]==


==Symptoms==
==[[Plummer-Vinson syndrome causes|Causes]]==


* [[Dysphagia]] (difficulty in swallowing)
==[[Plummer-Vinson syndrome differential diagnosis|Differentiating Plummer-Vinson syndrome from other Diseases]]==
* [[Pain]]
* [[Weakness]]
* [[Odynophagia]]
* Atrophic [[Glossitis]]
* Angular [[stomatitis]]


==Signs and tests==
==[[Plummer-Vinson syndrome epidemiology and demographics|Epidemiology and Demographics]]==


Serial contrasted gastrointestinal [[radiography]] or upper gastrointestinal [[endoscopy]] may reveal the web in the esophagus. [[Blood tests]] show a hypochromic [[microcytic anemia]] that is consistent with an iron-deficiency anemia. Biopsy of involved mucosa typically reveals epithelial atrophy (shrinking) and varying amounts of submucosal chronic inflammation.  Epithelial atypia or [[dysplasia]] may be present.
==[[Plummer-Vinson syndrome risk factors|Risk Factors]]==


The condition is associated with [[koilonychia]], [[glossitis]], [[cheilitis]], and [[splenomegaly]].
==[[Plummer-Vinson syndrome screening|Screening]]==


==Treatment==
==[[Plummer-Vinson syndrome natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


Treatment is primarily aimed at correcting the iron-deficiency anemia. Patients with Plummer-Vinson syndrome should receive [[iron]] supplementation in their [[Diet (nutrition)|diet]]. This may improve dysphagia and pain.
==Diagnosis==


If not, the web can be dilated during upper endoscopy to allow normal swallowing and passage of food.<ref name="pmid18031398">{{cite journal |author=Enomoto M, Kohmoto M, Arafa UA, ''et al'' |title=Plummer-Vinson syndrome successfully treated by endoscopic dilatation |journal=J. Gastroenterol. Hepatol. |volume=22 |issue=12 |pages=2348–51 |year=2007 |pmid=18031398 |doi=10.1111/j.1440-1746.2006.03430.x |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2007&volume=22&issue=12&spage=2348}}</ref>
[[Plummer-Vinson syndrome history and symptoms|History and Symptoms]] | [[Plummer-Vinson syndrome physical examination|Physical Examination]] | [[Plummer-Vinson syndrome laboratory findings|Laboratory Findings]] | [[Plummer-Vinson syndrome electrocardiogram|Electrocardiogram]] | [[Plummer-Vinson syndrome x ray|X Ray]] | [[Plummer-Vinson syndrome echocardiograph and ultrasound|Echocardiograph and Ultrasound]] | [[Plummer-Vinson syndrome CT|CT]] | | [[Plummer-Vinson syndrome MRI|MRI]] | [[Plummer-Vinson syndrome other imaging findings|Other Imaging Findings]] | [[Plummer-Vinson syndrome other diagnostic studies|Other Diagnostic Studies]]


==Prognosis==
==Treatment==
Patients generally respond well to treatment. Iron supplementation usually resolves the anemia, and corrects the [[glossodynia]] (tongue pain).
[[Plummer-Vinson syndrome medical therapy|Medical Therapy]] | [[Plummer-Vinson syndrome surgery|Surgery]] | [[Plummer-Vinson syndrome primary prevention|Primary Prevention]] | [[Plummer-Vinson syndrome secondary prevention|Secondary Prevention]] | [[Plummer-Vinson syndrome cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Plummer-Vinson syndrome future or investigational therapies|Future or Investigational Therapies]]
 
==Complications==
 
There is risk of perforation of the esophagus with the use of dilators for treatment.
Furthermore it is one of the risk factors for developing [[squamous cell carcinoma]] of the oesophagus.
 
==Prevention==
Good nutrition with adequate intake of iron may prevent this disorder.
 
==References==
{{Reflist|2}}


==Additional Resources==
==Case Studies==
* [http://www.nlm.nih.gov/medlineplus/ency/article/001158.htm Plummer-Vynson Syndrome]. MedlinePlus Medical Encyclopedia. US Federal Government public domain. Update Date: 1/2/2003. By: Jenifer K. Lehrer, M.D., Department of Gastroenterology, Graduate Hospital, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
[[Plummer-Vinson syndrome case study one|Case #1]]


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{{WikiDoc Sources}}
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[[Category:Disease]]
[[Category:Blood disorders]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Mature chapter]]

Latest revision as of 13:53, 6 August 2018

Plummer-Vinson syndrome
ICD-10 D50.1
ICD-9 280.8
DiseasesDB 10134
MedlinePlus 001158
MeSH D011004

For patient information, click here.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]

Synonyms and keywords: Paterson-Brown-Kelly syndrome; Plummer-Vinson-Patterson-Kelly syndrome; Paterson-Kelly syndrome; sideropenic dysphagia; chronic pharyngo-oesophagitis

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Plummer-Vinson syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | Echocardiograph and Ultrasound | CT | | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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