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{{Glucose-6-phosphate dehydrogenase deficiency}}
{{Glucose-6-phosphate dehydrogenase deficiency}}


{{CMG}}; {{AE}} {{MA}}
{{CMG}}; {{AE}} {{MA}}


==Overview==
==Overview==
G6PD deficiency is affecting 400 million people worldwide. atients of all age groups may develop [[favism]], but more often and severe in childern. African, Middle Eastern and South Asian people are affected the most. Men are more commonly affected by G6PD deficiency.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
*The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
*In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
===Prevalence===
===Prevalence===
*The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
* G6PD deficiency is affecting 400 million people worldwide. <ref name="pmid17611006">{{cite journal |vauthors=Mason PJ, Bautista JM, Gilsanz F |title=G6PD deficiency: the genotype-phenotype association |journal=Blood Rev. |volume=21 |issue=5 |pages=267–83 |date=September 2007 |pmid=17611006 |doi=10.1016/j.blre.2007.05.002 |url=}}</ref>
*In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
*The prevalence of [disease/malignancy] is estimated to be [number] cases annually.


===Case-fatality rate/Mortality rate===
===Case-fatality rate/Mortality rate===
*In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
* G6PD deficiency resulted in 4,100 deaths in 2013 and 3,400 deaths in 1990<ref name="pmid25530442">{{cite journal |vauthors= |title=Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 |journal=Lancet |volume=385 |issue=9963 |pages=117–71 |date=January 2015 |pmid=25530442 |pmc=4340604 |doi=10.1016/S0140-6736(14)61682-2 |url=}}</ref>
*The case-fatality rate/mortality rate of [disease name] is approximately [number range].


===Age===
===Age===
*Patients of all age groups may develop [disease name].
*Patients of all age groups may develop [[favism]] (acute [[hemolytic anemia]] from eating fava beans ), but more often and severe in childern.
*The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
*[Disease name] commonly affects individuals younger than/older than [number of years] years of age.
*[Chronic disease name] is usually first diagnosed among [age group].
*[Acute disease name] commonly affects [age group].


===Race===
===Race===
*There is no racial predilection to [disease name].
* African, Middle Eastern and South Asian people are affected the most.
*[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].
 
*
===Gender===
===Gender===
*[Disease name] affects men and women equally.
*Men are more commonly affected by G6PD deficiency than women, because it is an [[X-linked recessive]] disorder.  
*[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.


===Region===
===Region===
*The majority of [disease name] cases are reported in [geographical region].
*The majority of G6PD deficiency cases are reported in African, Middle Eastern and South Asian people. <ref name="pmid1984194">{{cite journal |vauthors=Beutler E |title=Glucose-6-phosphate dehydrogenase deficiency |journal=N. Engl. J. Med. |volume=324 |issue=3 |pages=169–74 |date=January 1991 |pmid=1984194 |doi=10.1056/NEJM199101173240306 |url=}}</ref>
 
*[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].
 
===Developed Countries===
 
===Developing Countries===


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


{{WH}}
{{WS}}
[[Category: (name of the system)]]
[[Category: (name of the system)]]
{{Glucose-6-phosphate dehydrogenase deficiency}}
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]
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==Overview==
==Epidemiology and Demographics==
* G6PDD is said to be the most common enzyme deficiency disease in the world, affecting approximately 400,000,000 people globally.<ref>http://www.rddiagnostics.com/g6pd_faq.htm</ref>
* A side effect of this disease is that it confers protection against [[malaria]], in particular the form of [[malaria]] caused by ''[[Plasmodium falciparum]]'', the most deadly form of [[malaria]].
* A similar relationship exists between [[malaria]] and [[sickle-cell disease]]. An explanation is that cells infected with the ''Plasmodium'' parasite are cleared more rapidly by the [[spleen]]. This phenomenon might give [[G6PD deficiency]] carriers an evolutionary advantage.
==References==
{{reflist|2}}
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Latest revision as of 15:54, 27 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

G6PD deficiency is affecting 400 million people worldwide. atients of all age groups may develop favism, but more often and severe in childern. African, Middle Eastern and South Asian people are affected the most. Men are more commonly affected by G6PD deficiency.

Epidemiology and Demographics

Prevalence

  • G6PD deficiency is affecting 400 million people worldwide. [1]

Case-fatality rate/Mortality rate

  • G6PD deficiency resulted in 4,100 deaths in 2013 and 3,400 deaths in 1990[2]

Age

  • Patients of all age groups may develop favism (acute hemolytic anemia from eating fava beans ), but more often and severe in childern.

Race

  • African, Middle Eastern and South Asian people are affected the most.

Gender

  • Men are more commonly affected by G6PD deficiency than women, because it is an X-linked recessive disorder.

Region

  • The majority of G6PD deficiency cases are reported in African, Middle Eastern and South Asian people. [3]

References

  1. Mason PJ, Bautista JM, Gilsanz F (September 2007). "G6PD deficiency: the genotype-phenotype association". Blood Rev. 21 (5): 267–83. doi:10.1016/j.blre.2007.05.002. PMID 17611006.
  2. "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117–71. January 2015. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604. PMID 25530442.
  3. Beutler E (January 1991). "Glucose-6-phosphate dehydrogenase deficiency". N. Engl. J. Med. 324 (3): 169–74. doi:10.1056/NEJM199101173240306. PMID 1984194.