Spondyloarthropathy causes: Difference between revisions
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==causes== | ==causes== | ||
Albiet, all the progresses have been made through investigating the cause of spondyloarthropathies, the exact cause of this disease remained unclear, however, the role of genetic have been seen through numerous studies have been made in this field of study. Studies demonstrated the role of HLA-B27 in the occurrence of spondyloarthropathies. | {{Spondyloarthropathy}}Albiet, all the progresses have been made through investigating the cause of spondyloarthropathies, the exact cause of this disease remained unclear, however, the role of genetic have been seen through numerous studies have been made in this field of study. Studies demonstrated the role of HLA-B27 in the occurrence of spondyloarthropathies. | ||
Here are some locus, gene, and function of definite and probable genetic risk factors for SpA. | Here are some locus, gene, and function of definite and probable genetic risk factors for SpA. | ||
{| style="border: 3px; font-size; 190%; margin: 1px; width: 800px" align="center" | |||
! colspan="7" style="background: #ff8c00; width: 800px:" | {{fontcolor|#FFF|Overview of the locus, gene, and function of definite and probable genetic risk factors for SpA}} | |||
|- | |||
! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Locus}} | |||
! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Gene}} | |||
! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Function}} | |||
! colspan="3" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Association with}} | |||
|- | |||
! style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Ankylosing spondylitis}} | |||
! style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Psoriasis}} | |||
! style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Inflammatory bowel disease}} | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |6p21.3 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |HLA-B27 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Antigene presentation | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |5q15 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |ERAP1 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Aminopeptidase | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |1p31.2 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |IL23R | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Cytokine receptor | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |2p15 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |21q22 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |12p13.2 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |TNFRSF1A | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Cytokine receptor | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |16q22 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |TRADD | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Signaling | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |9q32 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |TNFSF15 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Inflammatory cytokine | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |2q14 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |IL1A | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Inflammatory cytokine | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |2q12 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |IL1R2 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Cytokine receptor | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |9q34 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |CARD9 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Innate immune defence | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |4q21.1 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |ANTXR2 | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Vascular morphogenesis | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |.. | |||
|} |
Latest revision as of 12:03, 29 August 2018
causes
Spondyloarthropathy Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Spondyloarthropathy causes On the Web |
American Roentgen Ray Society Images of Spondyloarthropathy causes |
Risk calculators and risk factors for Spondyloarthropathy causes |
Albiet, all the progresses have been made through investigating the cause of spondyloarthropathies, the exact cause of this disease remained unclear, however, the role of genetic have been seen through numerous studies have been made in this field of study. Studies demonstrated the role of HLA-B27 in the occurrence of spondyloarthropathies.
Here are some locus, gene, and function of definite and probable genetic risk factors for SpA.
Overview of the locus, gene, and function of definite and probable genetic risk factors for SpA | ||||||
---|---|---|---|---|---|---|
Locus | Gene | Function | Association with | |||
Ankylosing spondylitis | Psoriasis | Inflammatory bowel disease | ||||
6p21.3 | HLA-B27 | Antigene presentation | Yes | .. | .. | |
5q15 | ERAP1 | Aminopeptidase | Yes | Probable | .. | |
1p31.2 | IL23R | Cytokine receptor | Yes | Yes | Yes | |
2p15 | .. | .. | Yes | .. | .. | |
21q22 | .. | .. | Yes | .. | .. | |
12p13.2 | TNFRSF1A | Cytokine receptor | Probable | .. | Yes | |
16q22 | TRADD | Signaling | Probable | .. | .. | |
9q32 | TNFSF15 | Inflammatory cytokine | Probable | .. | Yes | |
2q14 | IL1A | Inflammatory cytokine | Probable | .. | .. | |
2q12 | IL1R2 | Cytokine receptor | Probable | .. | .. | |
9q34 | CARD9 | Innate immune defence | Probable | .. | .. | |
4q21.1 | ANTXR2 | Vascular morphogenesis | Probable | .. | .. |