Sandbox: wdx causes: Difference between revisions
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{| | ==Differentiating Leukocytosis from Other Diseases== | ||
! colspan="4" | | {| | ||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | |||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | |||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | |||
! colspan="4" rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism | |||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital | |||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried | |||
! colspan="11" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations | |||
! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings | |||
! colspan="1" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard | |||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | |||
|- | |- | ||
! | ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | ||
! | ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | ||
! | ! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms | ||
| colspan="6" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs | |||
|- | |- | ||
| | ! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings | ||
|- | |- | ||
| | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic | ||
|1 | ! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Increased bone marrow production | ||
| | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils | ||
! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly | |||
| | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy | ||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other | |||
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr | |||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT | |||
|- | |- | ||
| | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous | ||
| | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive | ||
| | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC | ||
* | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB | ||
| | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | ||
* | |- | ||
* | ! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic | ||
! align="center" style="background:#DCDCDC;" |[[Granulocytosis|Hereditary neutrophilia]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
* Unknown | |||
* Germline mutation in [[CSF3R]] | |||
| align="center" style="background:#F5F5F5;" + | - | |||
| align="center" style="background:#F5F5F5;" + | + | |||
| align="center" style="background:#F5F5F5;" + | -- | |||
| align="center" style="background:#F5F5F5;" + | - | |||
| align="center" style="background:#F5F5F5;" + | + | |||
| align="center" style="background:#F5F5F5;" + | - | |||
| align="center" style="background:#F5F5F5;" + |Rare [[Dominance relationship|autosomal dominant]] genetic disorder | |||
| align="center" style="background:#F5F5F5;" + | | |||
* Positive family history | |||
| align="center" style="background:#F5F5F5;" + |Normal | |||
| align="center" style="background:#F5F5F5;" + |- | |||
| align="center" style="background:#F5F5F5;" + |- | |||
| align="center" style="background:#F5F5F5;" + |Nl | |||
| align="center" style="background:#F5F5F5;" + |- | |||
| align="center" style="background:#F5F5F5;" + |+ | |||
| align="center" style="background:#F5F5F5;" + |- | |||
| align="center" style="background:#F5F5F5;" + |- | |||
| align="center" style="background:#F5F5F5;" + |- | |||
| align="center" style="background:#F5F5F5;" + |↑ | |||
| align="center" style="background:#F5F5F5;" + |Nl | |||
| align="center" style="background:#F5F5F5;" + |Nl | |||
| align="center" style="background:#F5F5F5;" + | | |||
* Normal [[Granulocyte|granulocytes]] | |||
* [[Histiocyte|Histiocytes]] of Gaucher type | |||
| align="center" style="background:#F5F5F5;" + |Nl | |||
| align="center" style="background:#F5F5F5;" + |Nl | |||
| align="center" style="background:#F5F5F5;" + |Nl | |||
| align="center" style="background:#F5F5F5;" + |Nl | |||
| align="center" style="background:#F5F5F5;" + |[[Genetics|Genetic]] study | |||
| align="center" style="background:#F5F5F5;" + | | |||
* High [[leukocyte alkaline phosphatase]] | |||
* Progress to [[leukemia]] | |||
|- | |||
! align="center" style="background:#DCDCDC;" |Hereditary chronic neutrophilia | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Myeloproliferative neoplasm|Myeloproliferative neoplasms]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Polycythemia vera]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Microangiopathic hemolytic anemia]] (MAHA) | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |Leukoerythroblastosis | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |Immune thrombocytopenia | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! rowspan="12" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/ | |||
Rheumatology | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Leukocyte adhesion deficiency]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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|- | |||
! align="center" style="background:#DCDCDC;" |Cryopyrin-associated periodic syndromes | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Rheumatoid arthritis]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Juvenile rheumatoid arthritis|Juvenile onset rheumatoid arthritis]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Still's disease|Adult Still's disease]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Kawasaki disease]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Inflammatory bowel disease|IBD]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Sarcoidosis]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Hepatitis|Chronic hepatitis]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Sweet's syndrome|Sweet syndrome]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Gout|Acute gout]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infection | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Infection|Acute bacterial]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + |toxic granulations, Döhle bodies, and cytoplasmic vacuoles in neutrophils | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Infection|Chronic infection]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Infection|Viral infection]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Granuloma|Granulomatous]] infections | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Bronchiectasis]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Metabolic | |||
! align="center" style="background:#DCDCDC;" |[[Diabetic coma]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Acidosis]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Thyroid storm]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Cushing's syndrome|Hypercortisolism]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Seizure|Seizures]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medication | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Steroid|Steriod]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
* Release of granulocytes from the bone marrow | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |Myeloid growth factors | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Lithium]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Cytokine|Cytokines]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Catecholamine|Catecholamines]] ([[epinephrine]]) | |||
| align="center" style="background:#F5F5F5;" + | | |||
* Stimulation of bone marrow myelopoiesis | |||
* Egress into the circulation | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Tretinoin|ATRA]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! rowspan="10" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Allergy]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |Post [[splenectomy]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Down syndrome]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Smoking|Cigarette smoking]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Stress (medicine)|Stress]]/[[Physical exercise|exercise]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Infant|Infancy]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Pregnancy]] | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Platelet]] clumping | |||
| align="center" style="background:#F5F5F5;" + |Spurious | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! align="center" style="background:#DCDCDC;" |[[Cryoglobulinemia|Mixed cryoglobulinemia]] | |||
| align="center" style="background:#F5F5F5;" + |Spurious | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | |||
|} | |} |
Latest revision as of 21:38, 17 September 2018
Differentiating Leukocytosis from Other Diseases
Category | Condition | Etiology | Mechanism | Congenital | Acquried | Clinical manifestations | Para−clinical findings | Gold standard | Associated findings | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Demography | History | Symptoms | Signs | ||||||||||||||||||||||||||
Lab Findings | |||||||||||||||||||||||||||||
Physiologic | Increased bone marrow production | Demargination of peripheral blood neutrophils | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other | CBC | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | ||||||||||||
Autonomous | Reactive | WBC | HB | Plt | |||||||||||||||||||||||||
Hematologic | Hereditary neutrophilia |
|
- | + | -- | - | + | - | Rare autosomal dominant genetic disorder |
|
Normal | - | - | Nl | - | + | - | - | - | ↑ | Nl | Nl |
|
Nl | Nl | Nl | Nl | Genetic study |
|
Hereditary chronic neutrophilia | |||||||||||||||||||||||||||||
Myeloproliferative neoplasms | |||||||||||||||||||||||||||||
Polycythemia vera | |||||||||||||||||||||||||||||
Microangiopathic hemolytic anemia (MAHA) | |||||||||||||||||||||||||||||
Leukoerythroblastosis | |||||||||||||||||||||||||||||
Immune thrombocytopenia | |||||||||||||||||||||||||||||
Immunology/
Rheumatology |
Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |
Leukocyte adhesion deficiency | |||||||||||||||||||||||||||||
Cryopyrin-associated periodic syndromes | |||||||||||||||||||||||||||||
Rheumatoid arthritis | |||||||||||||||||||||||||||||
Juvenile onset rheumatoid arthritis | |||||||||||||||||||||||||||||
Adult Still's disease | |||||||||||||||||||||||||||||
Kawasaki disease | |||||||||||||||||||||||||||||
IBD | |||||||||||||||||||||||||||||
Sarcoidosis | |||||||||||||||||||||||||||||
Chronic hepatitis | |||||||||||||||||||||||||||||
Sweet syndrome | |||||||||||||||||||||||||||||
Acute gout | |||||||||||||||||||||||||||||
Infection | Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |
Acute bacterial | toxic granulations, Döhle bodies, and cytoplasmic vacuoles in neutrophils | ||||||||||||||||||||||||||||
Chronic infection | |||||||||||||||||||||||||||||
Viral infection | |||||||||||||||||||||||||||||
Granulomatous infections | |||||||||||||||||||||||||||||
Bronchiectasis | |||||||||||||||||||||||||||||
Metabolic | Diabetic coma | ||||||||||||||||||||||||||||
Acidosis | |||||||||||||||||||||||||||||
Thyroid storm | |||||||||||||||||||||||||||||
Hypercortisolism | |||||||||||||||||||||||||||||
Seizures | |||||||||||||||||||||||||||||
Medication | Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |
Steriod |
|
||||||||||||||||||||||||||||
Myeloid growth factors | |||||||||||||||||||||||||||||
Lithium | |||||||||||||||||||||||||||||
Cytokines | |||||||||||||||||||||||||||||
Catecholamines (epinephrine) |
|
||||||||||||||||||||||||||||
ATRA | |||||||||||||||||||||||||||||
Other | Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |
Allergy | |||||||||||||||||||||||||||||
Post splenectomy | |||||||||||||||||||||||||||||
Down syndrome | |||||||||||||||||||||||||||||
Cigarette smoking | |||||||||||||||||||||||||||||
Stress/exercise | |||||||||||||||||||||||||||||
Infancy | |||||||||||||||||||||||||||||
Pregnancy | |||||||||||||||||||||||||||||
Platelet clumping | Spurious | ||||||||||||||||||||||||||||
Mixed cryoglobulinemia | Spurious | ||||||||||||||||||||||||||||
Category | Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |