Sandbox: wdx causes: Difference between revisions

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==Differentiating Leukocytosis from Other Diseases==
==Differentiating Leukocytosis from Other Diseases==
* There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing ([[complete blood count]]).
{|
{|
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
! colspan="4" rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
! colspan="11" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings
! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings
! colspan="1" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! colspan="1" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
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! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
| colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
| colspan="6" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
|-
|-
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
|-
|-
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Increased bone marrow production
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
|-
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Primary
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Secondary
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
|-
|-
! rowspan="6" |Hematologic
! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic
|Hereditary neutrophilia
! align="center" style="background:#DCDCDC;" |[[Granulocytosis|Hereditary neutrophilia]]
!
| align="center" style="background:#F5F5F5;" + |
!
* Unknown
!
* Germline mutation in [[CSF3R]]
!
| align="center" style="background:#F5F5F5;" + | -
!
| align="center" style="background:#F5F5F5;" + | +
!
| align="center" style="background:#F5F5F5;" + | --
!
| align="center" style="background:#F5F5F5;" + | -
!
| align="center" style="background:#F5F5F5;" + | +
!
| align="center" style="background:#F5F5F5;" + | -
!
| align="center" style="background:#F5F5F5;" + |Rare [[Dominance relationship|autosomal dominant]] genetic disorder
!
| align="center" style="background:#F5F5F5;" + |
!
* Positive family history
!
| align="center" style="background:#F5F5F5;" + |Normal
!
| align="center" style="background:#F5F5F5;" + |-
!
| align="center" style="background:#F5F5F5;" + |-
!
| align="center" style="background:#F5F5F5;" + |Nl
!
| align="center" style="background:#F5F5F5;" + |-
!
| align="center" style="background:#F5F5F5;" + |+
!
| align="center" style="background:#F5F5F5;" + |-
!
| align="center" style="background:#F5F5F5;" + |-
!
| align="center" style="background:#F5F5F5;" + |-
!
| align="center" style="background:#F5F5F5;" + |↑
!
| align="center" style="background:#F5F5F5;" + |Nl
!
| align="center" style="background:#F5F5F5;" + |Nl
!
| align="center" style="background:#F5F5F5;" + |
* Normal [[Granulocyte|granulocytes]]
* [[Histiocyte|Histiocytes]] of Gaucher type
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |[[Genetics|Genetic]] study
| align="center" style="background:#F5F5F5;" + |
* High [[leukocyte alkaline phosphatase]]
* Progress to [[leukemia]]
|-
|-
|Chronic idiopathic neutrophilia
! align="center" style="background:#DCDCDC;" |Hereditary chronic neutrophilia
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|CML
! align="center" style="background:#DCDCDC;" |[[Myeloproliferative neoplasm|Myeloproliferative neoplasms]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
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!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|Polycythemia Vera
! align="center" style="background:#DCDCDC;" |[[Polycythemia vera]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|Hemolytic anemia
! align="center" style="background:#DCDCDC;" |[[Microangiopathic hemolytic anemia]] (MAHA)
!Marrow stimulation
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|Immature thrombocytopenia
! align="center" style="background:#DCDCDC;" |Leukoerythroblastosis
!Marrow stimulation
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
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!
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!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/
! align="center" style="background:#DCDCDC;" |Immune thrombocytopenia
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! rowspan="12" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/
Rheumatology
Rheumatology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
sequestration/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
Line 220: Line 276:
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
! align="center" style="background:#DCDCDC;" |[[Leukocyte adhesion deficiency]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |Cryopyrin-associated periodic syndromes
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Rheumatoid arthritis]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Juvenile rheumatoid arthritis|Juvenile onset rheumatoid arthritis]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Still's disease|Adult Still's disease]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Kawasaki disease]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Inflammatory bowel disease|IBD]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Sarcoidosis]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Hepatitis|Chronic hepatitis]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Sweet's syndrome|Sweet syndrome]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Gout|Acute gout]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infection
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
|-
|RA
! align="center" style="background:#DCDCDC;" |[[Infection|Acute bacterial]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |toxic granulations, Döhle bodies, and cytoplasmic vacuoles in neutrophils
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
!JRA
! align="center" style="background:#DCDCDC;" |[[Infection|Chronic infection]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
!IBD
! align="center" style="background:#DCDCDC;" |[[Infection|Viral infection]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|Chronic hepatitis
! align="center" style="background:#DCDCDC;" |[[Granuloma|Granulomatous]] infections
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|Acute Gout
! align="center" style="background:#DCDCDC;" |[[Bronchiectasis]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! rowspan="4" |'''Metabolic'''
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Metabolic
|Diabetic coma
! align="center" style="background:#DCDCDC;" |[[Diabetic coma]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|Acidosis
! align="center" style="background:#DCDCDC;" |[[Acidosis]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|Thyroid strom
! align="center" style="background:#DCDCDC;" |[[Thyroid storm]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
!Seizures
! align="center" style="background:#DCDCDC;" |[[Cushing's syndrome|Hypercortisolism]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infections
! align="center" style="background:#DCDCDC;" |[[Seizure|Seizures]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medication
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
sequestration/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
Line 494: Line 969:
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
! align="center" style="background:#DCDCDC;" |[[Steroid|Steriod]]
| align="center" style="background:#F5F5F5;" + |
* Release of granulocytes from the bone marrow
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |Myeloid growth factors
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Lithium]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Cytokine|Cytokines]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Catecholamine|Catecholamines]] ([[epinephrine]])
| align="center" style="background:#F5F5F5;" + |
* Stimulation of bone marrow myelopoiesis
* Egress into the circulation
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |[[Tretinoin|ATRA]]
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! rowspan="10" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
|-
!Acute
! align="center" style="background:#DCDCDC;" |[[Allergy]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
!Chronic
! align="center" style="background:#DCDCDC;" |Post [[splenectomy]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medications
! align="center" style="background:#DCDCDC;" |[[Down syndrome]]
! align="left" style="background:#DCDCDC;" |Steriod
| align="center" style="background:#F5F5F5;" + |
| align="left" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
Line 592: Line 1,291:
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
!Lithium
! align="center" style="background:#DCDCDC;" |[[Smoking|Cigarette smoking]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|Beta agonists
! align="center" style="background:#DCDCDC;" |[[Stress (medicine)|Stress]]/[[Physical exercise|exercise]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
!Cytokines
! align="center" style="background:#DCDCDC;" |[[Infant|Infancy]]
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
| rowspan="4" |Other
! align="center" style="background:#DCDCDC;" |[[Pregnancy]]
|'''Post splenectomy'''
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
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! align="center" style="background:#DCDCDC;" |[[Platelet]] clumping
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! align="center" style="background:#DCDCDC;" |[[Cryoglobulinemia|Mixed cryoglobulinemia]]
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
sequestration/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
Line 796: Line 1,484:
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|}
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<references />
*Leukocytosis is defined as an elevated white blood cell (WBC) count greater than 11,000 per mm3 (11.0 × 109 per L).
*The most common type of leukocytosis is neutrophilia.
**Neutrophilia can be defined as an increase in the absolute number of mature neutrophils to greater than 7,000 per mm3 [7.0 × 109 per L].

Latest revision as of 21:38, 17 September 2018

Differentiating Leukocytosis from Other Diseases

Category Condition Etiology Mechanism Congenital Acquried Clinical manifestations Para−clinical findings Gold standard Associated findings
Demography History Symptoms Signs
Lab Findings
Physiologic Increased bone marrow production Demargination of peripheral blood neutrophils Appearance Fever Abdominal pain BP Asplenia Hepatosplenomegaly Lymphadenopathy Joint redness Other CBC PBS Bone marrow exam ESR/CRP BUN/Cr LFT
Autonomous Reactive WBC HB Plt
Hematologic Hereditary neutrophilia
  • Unknown
  • Germline mutation in CSF3R
- + -- - + - Rare autosomal dominant genetic disorder
  • Positive family history
Normal - - Nl - + - - - Nl Nl Nl Nl Nl Nl Genetic study
Hereditary chronic neutrophilia
Myeloproliferative neoplasms
Polycythemia vera
Microangiopathic hemolytic anemia (MAHA)
Leukoerythroblastosis
Immune thrombocytopenia
Immunology/

Rheumatology

Condition Etiology Physiologic Autonomous increased bone marrow production Reactive increased bone marrow production Demargination of peripheral blood neutrophils Congenital Acquried Demography History Appearance Fever Abdominal pain BP Asplenia Hepatosplenomegaly Lymphadenopathy Joint redness Other signs WBC HB Plt PBS Bone marrow exam ESR/CRP BUN/Cr LFT Gold standard Associated findings
Leukocyte adhesion deficiency
Cryopyrin-associated periodic syndromes
Rheumatoid arthritis
Juvenile onset rheumatoid arthritis
Adult Still's disease
Kawasaki disease
IBD
Sarcoidosis
Chronic hepatitis
Sweet syndrome
Acute gout
Infection Condition Etiology Physiologic Autonomous increased bone marrow production Reactive increased bone marrow production Demargination of peripheral blood neutrophils Congenital Acquried Demography History Appearance Fever Abdominal pain BP Asplenia Hepatosplenomegaly Lymphadenopathy Joint redness Other signs WBC HB Plt PBS Bone marrow exam ESR/CRP BUN/Cr LFT Gold standard Associated findings
Acute bacterial toxic granulations, Döhle bodies, and cytoplasmic vacuoles in neutrophils
Chronic infection
Viral infection
Granulomatous infections
Bronchiectasis
Metabolic Diabetic coma
Acidosis
Thyroid storm
Hypercortisolism
Seizures
Medication Condition Etiology Physiologic Autonomous increased bone marrow production Reactive increased bone marrow production Demargination of peripheral blood neutrophils Congenital Acquried Demography History Appearance Fever Abdominal pain BP Asplenia Hepatosplenomegaly Lymphadenopathy Joint redness Other signs WBC HB Plt PBS Bone marrow exam ESR/CRP BUN/Cr LFT Gold standard Associated findings
Steriod
  • Release of granulocytes from the bone marrow
Myeloid growth factors
Lithium
Cytokines
Catecholamines (epinephrine)
  • Stimulation of bone marrow myelopoiesis
  • Egress into the circulation
ATRA
Other Condition Etiology Physiologic Autonomous increased bone marrow production Reactive increased bone marrow production Demargination of peripheral blood neutrophils Congenital Acquried Demography History Appearance Fever Abdominal pain BP Asplenia Hepatosplenomegaly Lymphadenopathy Joint redness Other signs WBC HB Plt PBS Bone marrow exam ESR/CRP BUN/Cr LFT Gold standard Associated findings
Allergy
Post splenectomy
Down syndrome
Cigarette smoking
Stress/exercise
Infancy
Pregnancy
Platelet clumping Spurious
Mixed cryoglobulinemia Spurious
Category Condition Etiology Physiologic Autonomous increased bone marrow production Reactive increased bone marrow production Demargination of peripheral blood neutrophils Congenital Acquried Demography History Appearance Fever Abdominal pain BP Asplenia Hepatosplenomegaly Lymphadenopathy Joint redness Other signs WBC HB Plt PBS Bone marrow exam ESR/CRP BUN/Cr LFT Gold standard Associated findings