Thrombotic thrombocytopenic purpura overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Thrombotic thrombocytopenic purpura''' ('''TTP''' or ''Moschcowitz disease'') is a [[rare disease|rare]] disorder of the [[coagulation|blood-coagulation]] system, causing multiple blood clots to form in blood vessels around the body.<ref name="MedPlus"> | '''Thrombotic thrombocytopenic purpura''' ('''TTP''' or ''Moschcowitz disease'') is a [[rare disease|rare]] disorder of the [[coagulation|blood-coagulation]] system, causing multiple blood clots to form in blood vessels around the body.<ref name="MedPlus"> | ||
Latest revision as of 19:24, 27 September 2018
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Thrombotic thrombocytopenic purpura Microchapters |
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Differentiating Thrombotic thrombocytopenic purpura from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Thrombotic thrombocytopenic purpura overview On the Web |
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American Roentgen Ray Society Images of Thrombotic thrombocytopenic purpura overview |
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Directions to Hospitals Treating Thrombotic thrombocytopenic purpura |
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Risk calculators and risk factors for Thrombotic thrombocytopenic purpura overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Thrombotic thrombocytopenic purpura (TTP or Moschcowitz disease) is a rare disorder of the blood-coagulation system, causing multiple blood clots to form in blood vessels around the body.[1] Most cases of TTP arise from deficiency or inhibition of the enzyme ADAMTS13, which is responsible for cleaving large multimers of von Willebrand factor.[2] This leads to hemolysis and end-organ damage, and may require plasmapheresis therapy.