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| == Splenomegaly differential: ==
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| ! rowspan="2" |Diseases
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| ! colspan="5" |Symptoms
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| ! colspan="3" |Signs/Physical Exam
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| ! colspan="3" |Labs
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| ! rowspan="2" |Imaging
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| |-
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| !Fatigue
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| !Fever
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| !SOB
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| !Dark urine
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| !Weight loss
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| !Jaundice
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| !Ascites
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| !JVP
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| !Fe studies
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| !LFTs
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| !CBC and Peripheral smear
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| |-
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| |Portal vein thrombosis
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| |-
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| |CHF
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| |-
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| |Cirrhosis
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| |-
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| |Hemolysis
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| |Chronic anemia
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| |-
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| |Malaria
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| |Kala-azar (visceral leishmaniasis)
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| |Sarcoidosis
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| |Amyloidosis
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| |Thalassemia
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| |Gaucher/Niemann-Pick disease
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| |Leukemia
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| |Lymphoma
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| |Myeloproliferative disorders
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| |}
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