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{{Thrombotic thrombocytopenic purpura}}


{{Thrombotic thrombocytopenic purpura}}
{{CMG}}; {{AE}} {{S.G.}}
{{CMG}}
==Overview==
==Overview==
The most proportion of TTP cases occurred after 40 years, black race and femal sex. Congenital forms  occur in children.
==Epidemiology and Demographics==
==Epidemiology and Demographics==
The incidence of TTP is about 4-6 per million people per year. As with most other [[autoimmune disorder]]s, idiopathic TTP occurs more often in women and blacks, while the secondary forms do not show this distribution.
===Incidence===
*The incidence of acuired TTP is about 0.3 per 100,000 adult per year.<ref name="pmid237293722">{{cite journal |vauthors=Reese JA, Muthurajah DS, Kremer Hovinga JA, Vesely SK, Terrell DR, George JN |title=Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired Adamts13 deficiency: comparison of incidence, demographic and clinical features |journal=Pediatr Blood Cancer |volume=60 |issue=10 |pages=1676–82 |date=October 2013 |pmid=23729372 |doi=10.1002/pbc.24612 |url=}}</ref>
* Data suggests the increased risk of TTP in black race and femal sex.<ref name="pmid207993582">{{cite journal |vauthors=Terrell DR, Vesely SK, Kremer Hovinga JA, Lämmle B, George JN |title=Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes |journal=Am. J. Hematol. |volume=85 |issue=11 |pages=844–7 |date=November 2010 |pmid=20799358 |pmc=3420337 |doi=10.1002/ajh.21833 |url=}}</ref>
 
===Prevalence===
*The incidence of TTP is approximately [number range] per 100,000 individuals worldwide.<ref name="pmid159781002">{{cite journal |vauthors=Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JA, George JN |title=The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency |journal=J. Thromb. Haemost. |volume=3 |issue=7 |pages=1432–6 |date=July 2005 |pmid=15978100 |doi=10.1111/j.1538-7836.2005.01436.x |url=}}</ref>
*In 2005, the prevalence of TTP was estimated to be 3 cases per 1000,000 individuals worldwide.<ref name="pmid15978100">{{cite journal |vauthors=Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JA, George JN |title=The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency |journal=J. Thromb. Haemost. |volume=3 |issue=7 |pages=1432–6 |date=July 2005 |pmid=15978100 |doi=10.1111/j.1538-7836.2005.01436.x |url=}}</ref>
 
===Age===
*Patients of all age groups may developTTP.
*The incidence of TTP increases with age; the median age at diagnosis is 40 years. TTP often occurs after 40 years.
 
===Race===
*TTP usually affects individuals of the black [[race]].<ref name="pmid20799358">{{cite journal |vauthors=Terrell DR, Vesely SK, Kremer Hovinga JA, Lämmle B, George JN |title=Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes |journal=Am. J. Hematol. |volume=85 |issue=11 |pages=844–7 |date=November 2010 |pmid=20799358 |pmc=3420337 |doi=10.1002/ajh.21833 |url=}}</ref><ref name="pmid273832022">{{cite journal |vauthors=Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P |title=Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors |journal=PLoS ONE |volume=11 |issue=7 |pages=e0156679 |date=2016 |pmid=27383202 |pmc=4934773 |doi=10.1371/journal.pone.0156679 |url=}}</ref>
===Gender===
*Females are more commonly affected by TTP than men. The females to men ratio is approximately 2 to 1.<ref name="pmid20799358" /><ref name="pmid23729372">{{cite journal |vauthors=Reese JA, Muthurajah DS, Kremer Hovinga JA, Vesely SK, Terrell DR, George JN |title=Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired Adamts13 deficiency: comparison of incidence, demographic and clinical features |journal=Pediatr Blood Cancer |volume=60 |issue=10 |pages=1676–82 |date=October 2013 |pmid=23729372 |doi=10.1002/pbc.24612 |url=}}</ref>
 
===Region===
*The majority of TTP cases are reported in black african and caribbean people.<ref name="pmid27383202">{{cite journal |vauthors=Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P |title=Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors |journal=PLoS ONE |volume=11 |issue=7 |pages=e0156679 |date=2016 |pmid=27383202 |pmc=4934773 |doi=10.1371/journal.pone.0156679 |url=}}</ref>
 
 
==References==
==References==
{{reflist|2}}
{{Reflist|2}}
 
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Latest revision as of 17:11, 3 October 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

The most proportion of TTP cases occurred after 40 years, black race and femal sex. Congenital forms occur in children.

Epidemiology and Demographics

Incidence

  • The incidence of acuired TTP is about 0.3 per 100,000 adult per year.[1]
  • Data suggests the increased risk of TTP in black race and femal sex.[2]

Prevalence

  • The incidence of TTP is approximately [number range] per 100,000 individuals worldwide.[3]
  • In 2005, the prevalence of TTP was estimated to be 3 cases per 1000,000 individuals worldwide.[4]

Age

  • Patients of all age groups may developTTP.
  • The incidence of TTP increases with age; the median age at diagnosis is 40 years. TTP often occurs after 40 years.

Race

  • TTP usually affects individuals of the black race.[5][6]

Gender

  • Females are more commonly affected by TTP than men. The females to men ratio is approximately 2 to 1.[5][7]

Region

  • The majority of TTP cases are reported in black african and caribbean people.[8]


References

  1. ↑ Reese JA, Muthurajah DS, Kremer Hovinga JA, Vesely SK, Terrell DR, George JN (October 2013). "Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired Adamts13 deficiency: comparison of incidence, demographic and clinical features". Pediatr Blood Cancer. 60 (10): 1676–82. doi:10.1002/pbc.24612. PMID 23729372.
  2. ↑ Terrell DR, Vesely SK, Kremer Hovinga JA, Lämmle B, George JN (November 2010). "Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes". Am. J. Hematol. 85 (11): 844–7. doi:10.1002/ajh.21833. PMC 3420337. PMID 20799358.
  3. ↑ Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JA, George JN (July 2005). "The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency". J. Thromb. Haemost. 3 (7): 1432–6. doi:10.1111/j.1538-7836.2005.01436.x. PMID 15978100.
  4. ↑ Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JA, George JN (July 2005). "The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency". J. Thromb. Haemost. 3 (7): 1432–6. doi:10.1111/j.1538-7836.2005.01436.x. PMID 15978100.
  5. ↑ 5.0 5.1 Terrell DR, Vesely SK, Kremer Hovinga JA, Lämmle B, George JN (November 2010). "Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes". Am. J. Hematol. 85 (11): 844–7. doi:10.1002/ajh.21833. PMC 3420337. PMID 20799358.
  6. ↑ Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P (2016). "Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors". PLoS ONE. 11 (7): e0156679. doi:10.1371/journal.pone.0156679. PMC 4934773. PMID 27383202.
  7. ↑ Reese JA, Muthurajah DS, Kremer Hovinga JA, Vesely SK, Terrell DR, George JN (October 2013). "Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired Adamts13 deficiency: comparison of incidence, demographic and clinical features". Pediatr Blood Cancer. 60 (10): 1676–82. doi:10.1002/pbc.24612. PMID 23729372.
  8. ↑ Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P (2016). "Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors". PLoS ONE. 11 (7): e0156679. doi:10.1371/journal.pone.0156679. PMC 4934773. PMID 27383202.

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