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! Differentiating features !! Leukemia !! Leukemoid reaction | |||
|- | |||
! Causes | |||
| Carcinogens || Infectious agents, biologically active substances and | |||
products of tissue destruction | |||
|- | |||
! Pathogenesis | |||
| The transformation of normal haematopoietic | |||
cells to a tumor | |||
| Activation of normal hematopoiesis and exit of immature leukocytes | |||
into the bloodstream. | |||
|- | |||
! Duration | |||
| Chronic | |||
| Temporary and reversible | |||
|- | |||
! Genetic level | |||
| Defect | |||
| No defect | |||
|- | |||
! Splenomegaly | |||
| Present | |||
| Not present | |||
|- | |||
! Peripheral blood | |||
| Immature cells, pancytopenia | |||
| Mature and immature granulocytes with left shift | |||
|- | |||
! Bone marrow | |||
| Increase in blasts and immature cells | |||
| Myeloid hyperplasia and normal morphology | |||
|- | |||
! LAP score | |||
| Low | |||
| High | |||
|- | |||
! Toxic granules | |||
(suggestive of infection) | |||
| Absent | |||
| Present | |||
|- | |||
! Dohle inclusion bodies | |||
| Absent | |||
| Present |
Latest revision as of 14:25, 9 October 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Differentiating features | Leukemia | Leukemoid reaction |
---|---|---|
Causes | Carcinogens | Infectious agents, biologically active substances and
products of tissue destruction |
Pathogenesis | The transformation of normal haematopoietic
cells to a tumor |
Activation of normal hematopoiesis and exit of immature leukocytes
into the bloodstream. |
Duration | Chronic | Temporary and reversible |
Genetic level | Defect | No defect |
Splenomegaly | Present | Not present |
Peripheral blood | Immature cells, pancytopenia | Mature and immature granulocytes with left shift |
Bone marrow | Increase in blasts and immature cells | Myeloid hyperplasia and normal morphology |
LAP score | Low | High |
Toxic granules
(suggestive of infection) |
Absent | Present |
Dohle inclusion bodies | Absent | Present |