Renal cell carcinoma causes: Difference between revisions

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__NOTOC__
__NOTOC__
{{Renal cell carcinoma}}
{{Renal cell carcinoma}}
{{CMG}} {{AE}} {{F.K}}
==Overview==
==Overview==
The causes of renal cell carcinoma include von hippel lindau (VHL), [[hereditary paragangliomas]], [[leiomyomatosis]], [[birt-hogg-dube syndrome]], and several other genetic factors.
The causes of renal cell carcinoma include von hippel-lindau (VHL), hereditary [[paragangliomas]], [[leiomyomatosis]], [[Birt-Hogg-Dube syndrome|birt-hogg-dube syndrome]], and several other genetic factors.


==Causes==
==Causes==
Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma.
Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma.<ref name="pmid24359990">{{cite journal |vauthors=Haas NB, Nathanson KL |title=Hereditary kidney cancer syndromes |journal=Adv Chronic Kidney Dis |volume=21 |issue=1 |pages=81–90 |date=January 2014 |pmid=24359990 |pmc=3872053 |doi=10.1053/j.ackd.2013.10.001 |url=}}</ref><ref name="pmid20448661">{{cite journal |vauthors=Linehan WM, Srinivasan R, Schmidt LS |title=The genetic basis of kidney cancer: a metabolic disease |journal=Nat Rev Urol |volume=7 |issue=5 |pages=277–85 |date=May 2010 |pmid=20448661 |pmc=2929006 |doi=10.1038/nrurol.2010.47 |url=}}</ref><ref name="pmid23038766">{{cite journal |vauthors=Linehan WM |title=Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics |journal=Genome Res. |volume=22 |issue=11 |pages=2089–100 |date=November 2012 |pmid=23038766 |pmc=3483538 |doi=10.1101/gr.131110.111 |url=}}</ref>


The following tables show the sporadic and hereditary renal-cell carcinomas and associated causes:
The following tables show the sporadic and hereditary renal-cell carcinomas and associated causes:
====Sporadic Forms of Renal Cell Carcinoma====
====Sporadic Forms of Renal Cell Carcinoma====
{| border="1" style="border-collapse:collapse; text-align:left;" cellpadding="5" align="center"
{| style="border-collapse:collapse; text-align:left;" cellpadding="5" border="1" align="center"
|+ '''''Sporadic Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med | year= 2005 | volume= 353 |issue= 23 | pages= 2477-90 | pmid=16339096 | doi=10.1056/NEJMra043172 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }} </ref>'''''
|+ '''''Sporadic Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med | year= 2005 | volume= 353 |issue= 23 | pages= 2477-90 | pmid=16339096 | doi=10.1056/NEJMra043172 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }} </ref>'''''
| bgcolor="#d9ff54"|'''Histologic Appearance''' ||bgcolor="#d9ff54"|'''Incidence'''||bgcolor="#d9ff54"|'''Gene'''||bgcolor="#d9ff54"|'''Frequency'''
| style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Histologic Appearance''' || style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Incidence'''|| style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Gene'''|| style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Frequency'''
|-
|-
| bgcolor="#ececec"|'''Conventional (Clear Cell)''' || 75 || VHL|| 60 %  
| bgcolor="#DCDCDC" |'''Conventional (Clear Cell)''' || 75 || VHL|| 60 %  
|-
|-
| bgcolor="#ececec"|'''Papillary''' || 12|| MET <br> TFE3|| 13 %<br> < 1 %
| bgcolor="#DCDCDC" |'''Papillary''' || 12|| MET <br> TFE3|| 13 %<br> < 1 %
|-
|-
| bgcolor="#ececec"|'''Chromophobe''' || 4  ||  ||
| bgcolor="#DCDCDC" |'''Chromophobe''' || 4  ||  ||
|-
|-
| bgcolor="#ececec"|'''Oncocytoma''' || 4 ||  ||
| bgcolor="#DCDCDC" |'''Oncocytoma''' || 4 ||  ||
|-
|-
|bgcolor="#ececec"|'''Collecting Duct''' || < 1 ||  ||
| bgcolor="#DCDCDC" |'''Collecting Duct''' || < 1 ||  ||
|-
|-
|bgcolor="#ececec"|'''Unclassified''' || 3 - 5 ||  ||
| bgcolor="#DCDCDC" |'''Unclassified''' || 3 - 5 ||  ||
|}
|}
<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup>
<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup>


====Hereditary Forms of Renal Cell Carcinoma====
====Hereditary Forms of Renal Cell Carcinoma====
{| border="1" style="border-collapse:collapse; text-align:left;" cellpadding="5" align="center"
{| style="border-collapse:collapse; text-align:left;" cellpadding="5" border="1" align="center"
|+ '''''Hereditary Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal|author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med |year= 2005 | volume= 353 |issue= 23 | pages= 2477-90 | pmid=16339096 |doi=10.1056/NEJMra043172 | pmc=|url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }}</ref>'''''
|+ '''''Hereditary Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal|author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med |year= 2005 | volume= 353 |issue= 23 | pages= 2477-90 | pmid=16339096 |doi=10.1056/NEJMra043172 | pmc=|url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }}</ref>'''''


 
| style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Syndrome''' || style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Associated Gene'''|| style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Common Histological Appearance'''
| bgcolor="#d9ff54"|'''Syndrome''' || bgcolor="#d9ff54"|'''Associated Gene'''||bgcolor="#d9ff54"|'''Common Histological Appearance'''
|-
|-
| bgcolor="#ececec"|'''VHL Disease''' || VHL || Conventional (Clear Cell)
| bgcolor="#DCDCDC" |'''VHL Disease''' || VHL || Conventional (Clear Cell)
|-
|-
| bgcolor="#ececec"|'''FCRC''' || Chromosome 3p translocation || Conventional (Clear Cell)
| bgcolor="#DCDCDC" |'''FCRC''' || Chromosome 3p translocation || Conventional (Clear Cell)
|-
|-
| bgcolor="#ececec"|'''Hereditary Paraganglioma''' || SDHB || Conventional (Clear Cell)
| bgcolor="#DCDCDC" |'''Hereditary Paraganglioma''' || SDHB || Conventional (Clear Cell)
|-
|-
| bgcolor="#ececec"|'''HPRC''' || MET || Papillary
| bgcolor="#DCDCDC" |'''HPRC''' || MET || Papillary
|-
|-
| bgcolor="#ececec"|'''HLRCC''' || FH || Papillary
| bgcolor="#DCDCDC" |'''HLRCC''' || FH || Papillary
|-
|-
|bgcolor="#ececec"|'''Birt-Hogg-Dube Syndrome''' || BHD || Chromophobe / Oncocytoma
| bgcolor="#DCDCDC" |'''Birt-Hogg-Dube Syndrome''' || BHD || Chromophobe / Oncocytoma
|}
|}
<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup>
<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup>
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[[Category:Kidney diseases]]
[[Category:Kidney diseases]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Nephrology]]
[[Category:Mature chapter]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Nephrology]]
[[Category:Nephrology]]
[[Category:Mature chapter]]
[[Category:Surgery]]

Latest revision as of 15:20, 10 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

The causes of renal cell carcinoma include von hippel-lindau (VHL), hereditary paragangliomas, leiomyomatosis, birt-hogg-dube syndrome, and several other genetic factors.

Causes

Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma.[1][2][3]

The following tables show the sporadic and hereditary renal-cell carcinomas and associated causes:

Sporadic Forms of Renal Cell Carcinoma

Sporadic Forms of Renal Cell Carcinoma[4]
Histologic Appearance Incidence Gene Frequency
Conventional (Clear Cell) 75 VHL 60 %
Papillary 12 MET
TFE3		 13 %
< 1 %
Chromophobe 4
Oncocytoma 4
Collecting Duct < 1
Unclassified 3 - 5
Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90

Hereditary Forms of Renal Cell Carcinoma

Hereditary Forms of Renal Cell Carcinoma[4]
Syndrome Associated Gene Common Histological Appearance
VHL Disease VHL Conventional (Clear Cell)
FCRC Chromosome 3p translocation Conventional (Clear Cell)
Hereditary Paraganglioma SDHB Conventional (Clear Cell)
HPRC MET Papillary
HLRCC FH Papillary
Birt-Hogg-Dube Syndrome BHD Chromophobe / Oncocytoma
Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90

References

  1. ↑ Haas NB, Nathanson KL (January 2014). "Hereditary kidney cancer syndromes". Adv Chronic Kidney Dis. 21 (1): 81–90. doi:10.1053/j.ackd.2013.10.001. PMC 3872053. PMID 24359990.
  2. ↑ Linehan WM, Srinivasan R, Schmidt LS (May 2010). "The genetic basis of kidney cancer: a metabolic disease". Nat Rev Urol. 7 (5): 277–85. doi:10.1038/nrurol.2010.47. PMC 2929006. PMID 20448661.
  3. ↑ Linehan WM (November 2012). "Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics". Genome Res. 22 (11): 2089–100. doi:10.1101/gr.131110.111. PMC 3483538. PMID 23038766.
  4. ↑ 4.0 4.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.
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