Lymphomatoid granulomatosis natural history: Difference between revisions
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{{Lymphomatoid granulomatosis}} | {{Lymphomatoid granulomatosis}} | ||
{{CMG}}; {{AE}} {{kakbar}} | |||
==Overview== | |||
Prognosis is generally variable and the 5-year mortality rate of patients with Lymphmatoid granulomatosis is approximately 63-90%. In many instances there is totally remission of the disease | |||
==Natural History, Complications, and Prognosis== | |||
===Natural History=== | |||
*The symptoms of Lymphomatoid granulomatosis usually develop in the fifth to the sixth decade of life, and start with symptoms such as [[Cough]], [[Dyspnea]] , and [[Chest pain|Chest tightness]]. Patient mostly present with pulmonary symptoms but in 40-50% of cases patients will present with cutaneous symptoms and then 30 present of patients will present with CNS symptoms.<ref name="MessanaMarburger2015">{{cite journal|last1=Messana|first1=Kate|last2=Marburger|first2=Trent|last3=Bergfeld|first3=Wilma|title=EBV-Negative Cutaneous Lymphomatoid Granulomatosis With Concomitant EBV-Positive Pulmonary Involvement|journal=The American Journal of Dermatopathology|volume=37|issue=9|year=2015|pages=707–711|issn=0193-1091|doi=10.1097/DAD.0000000000000198}}</ref> | |||
===Complications=== | |||
*The most common complication of the disease can be [[Lymphoma]]. In some cases the disease does progress to lymphoma if patient is not cared for.<ref name="GrimmO'Malley2019">{{cite journal|last1=Grimm|first1=Kate E.|last2=O'Malley|first2=Dennis P.|title=Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues|journal=Annals of Diagnostic Pathology|volume=38|year=2019|pages=6–10|issn=10929134|doi=10.1016/j.anndiagpath.2018.09.014}}</ref><ref name="pmid25321327">{{cite journal| author=Song JY, Pittaluga S, Dunleavy K, Grant N, White T, Jiang L et al.| title=Lymphomatoid granulomatosis--a single institute experience: pathologic findings and clinical correlations. | journal=Am J Surg Pathol | year= 2015 | volume= 39 | issue= 2 | pages= 141-56 | pmid=25321327 | doi=10.1097/PAS.0000000000000328 | pmc=4293220 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25321327 }} </ref> | |||
===Prognosis=== | |||
*Depending on the extent of the disease at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.<ref name="pmid20672711">{{cite journal| author=Halvani A, Owlia MB, Sami R| title=Lymphomatoid granulomatosis with splenomegaly and pancytopenia. | journal=Zhongguo Fei Ai Za Zhi | year= 2010 | volume= 13 | issue= 1 | pages= 84-6 | pmid=20672711 | doi=10.3779/j.issn.1009-3419.2010.01.17 | pmc=6000673 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20672711 }} </ref> | |||
==References== | ==References== | ||
{{ | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category: | [[Category: (name of the system)]] | ||
Latest revision as of 21:10, 18 December 2018
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Lymphomatoid granulomatosis Microchapters |
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Differentiating Lymphomatoid granulomatosis from other Diseases |
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Risk calculators and risk factors for Lymphomatoid granulomatosis natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kamal Akbar, M.D.[2]
Overview
Prognosis is generally variable and the 5-year mortality rate of patients with Lymphmatoid granulomatosis is approximately 63-90%. In many instances there is totally remission of the disease
Natural History, Complications, and Prognosis
Natural History
- The symptoms of Lymphomatoid granulomatosis usually develop in the fifth to the sixth decade of life, and start with symptoms such as Cough, Dyspnea , and Chest tightness. Patient mostly present with pulmonary symptoms but in 40-50% of cases patients will present with cutaneous symptoms and then 30 present of patients will present with CNS symptoms.[1]
Complications
- The most common complication of the disease can be Lymphoma. In some cases the disease does progress to lymphoma if patient is not cared for.[2][3]
Prognosis
- Depending on the extent of the disease at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.[4]
References
- ↑ Messana, Kate; Marburger, Trent; Bergfeld, Wilma (2015). "EBV-Negative Cutaneous Lymphomatoid Granulomatosis With Concomitant EBV-Positive Pulmonary Involvement". The American Journal of Dermatopathology. 37 (9): 707–711. doi:10.1097/DAD.0000000000000198. ISSN 0193-1091.
- ↑ Grimm, Kate E.; O'Malley, Dennis P. (2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. ISSN 1092-9134.
- ↑ Song JY, Pittaluga S, Dunleavy K, Grant N, White T, Jiang L; et al. (2015). "Lymphomatoid granulomatosis--a single institute experience: pathologic findings and clinical correlations". Am J Surg Pathol. 39 (2): 141–56. doi:10.1097/PAS.0000000000000328. PMC 4293220. PMID 25321327.
- ↑ Halvani A, Owlia MB, Sami R (2010). "Lymphomatoid granulomatosis with splenomegaly and pancytopenia". Zhongguo Fei Ai Za Zhi. 13 (1): 84–6. doi:10.3779/j.issn.1009-3419.2010.01.17. PMC 6000673. PMID 20672711.