Hodgkin's lymphoma history and symptoms: Difference between revisions

Jump to navigation Jump to search
← Older edit
VisualWikitext
Jyostna Chouturi (talk | contribs)
nocaptcha
9,554 edits
No edit summary
Shyam Patel (talk | contribs)
nocaptcha
3,105 edits
 
(39 intermediate revisions by 5 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Hodgkin's lymphoma}}
{{Hodgkin's lymphoma}}
{{CMG}}
{{CMG}} {{shyam}}; {{AE}} {{M.B}}
==Overview==
The most common symptoms of classic Hodgkin lymphoma include painless localized peripheral lymphadenopathy, B symptoms (fever, night sweats, weight loss), and pruritus. Less common symptoms of Hodgkin lymphoma include [[cough]], [[chest pain]], breathing problems, pain or feeling of fullness below the ribs, pain in lymph nodes after drinking alcohol, skin blushing or [[flushing]], [[bone pain]], and [[leg swelling]]. 
 
==History and Symptoms==
==History and Symptoms==
Swollen but painless [[lymph node]]s are the most common sign of Hodgkin's lymphoma, often occurring in the neck. The lymph nodes of the chest are often affected and these may be noticed on a chest x-ray.
The presentation of Hodgkin lymphoma may vary depending on the location of tumor and organ involvement, mass size and stage of disease.<ref>{{Cite journal
| author = [[P. M. Mauch]], [[L. A. Kalish]], [[M. Kadin]], [[C. N. Coleman]], [[R. Osteen]] & [[S. Hellman]]
| title = Patterns of presentation of Hodgkin disease. Implications for etiology and pathogenesis
| journal = [[Cancer]]
| volume = 71
| issue = 6
| pages = 2062–2071
| year = 1993
| month = March
| pmid = 8443755
}}</ref><ref>{{Cite journal
| author = [[Stephen M. Ansell]]
| title = Hodgkin Lymphoma: Diagnosis and Treatment
| journal = [[Mayo Clinic proceedings]]
| volume = 90
| issue = 11
| pages = 1574–1583
| year = 2015
| month = November
| doi = 10.1016/j.mayocp.2015.07.005
| pmid = 26541251
}}</ref><ref>{{Cite journal
| author = [[P. G. Gobbi]], [[C. Cavalli]], [[A. Gendarini]], [[A. Crema]], [[G. Ricevuti]], [[M. Federico]], [[U. Di Prisco]] & [[E. Ascari]]
| title = Reevaluation of prognostic significance of symptoms in Hodgkin's disease
| journal = [[Cancer]]
| volume = 56
| issue = 12
| pages = 2874–2880
| year = 1985
| month = December
| pmid = 4052959
}}</ref>
 
=== History ===
* Hodgkin lymphoma begins at a single site of the [[lymphatic system]], generally a [[lymph node]], and then progresses to adjacent lymph nodes through [[Lymphatic system|lymphatic vessels]] before spreading to other sites and organs. The majority of patients present with an [[asymptomatic]] [[lymphadenopathy]] most often a site above the [[Thoracic diaphragm|diaphragm]], or as an accidental [[mediastinal mass]] on [[Chest X-ray|chest x-ray]].
 
* Occasionally patients may present with nonspecific symptoms and signs that are more compatible with infection than malignant disease.
* B symptoms or constitutional symptoms, include [[fever]] (>100.4°F), drenching night sweats, and unexplained [[weight loss]] (>10% of total body weight) may present up to 50 percent of patients with advanced disease. 
* [[Itch|Pruritus]] may be present before the diagnosis of Hodgkin lymphoma by months or even a year or more.
 
=== Symptoms ===


About one-third of people with Hodgkin's disease may also notice some systemic symptoms, such as low-grade fever, night sweats, weight loss, itchy skin ([[itch|pruritus]]), or [[fatigue (physical)|fatigue]].  Classically, involved nodes are painful after alcohol consumption, though this phenomenon is rare.  Patients may also present with a cyclic high-grade fever known as [[Pel-Ebstein fever]], although there is debate as to whether or not this truly exists. <ref> {{cite journal | last=Asher | first=Richard | title=Making Sense | journal=The New England Journal of Medicine | volume=333 | pages 66-67 | date=[[July 6]], [[1995]] }} </ref> Systemic symptoms such as fever and weight loss are known as [[B symptoms]].
==== Common symptoms ====
* Painless  [[lymphadenopathy]] with a rubbery consistency most often a site above the [[Thoracic diaphragm|diaphragm]],
* Systemic B symptoms:
:* [[Fever]] ([[Pel-Ebstein fever]]): persistent temperature >38°C (>100.4°F)<ref>{{Cite journal
| author = [[G. R. Good]] & [[M. J. DiNubile]]
| title = Images in clinical medicine. Cyclic fever in Hodgkin's disease (Pel-Ebstein fever)
| journal = [[The New England journal of medicine]]
| volume = 332
| issue = 7
| pages = 436
| year = 1995
| month = February
| doi = 10.1056/NEJM199502163320705
| pmid = 7824016
}}</ref>  
:* Drenching [[night sweats]]
:* Unexplained weight loss >10% of total body weight within the past 6 months


==References==
* Pruritus
{{reflist|2}}
* Fatigue
*Mediastinal mass effects include:
:* Chest pain
:* Cough
:* Shortness of breath


[[Category:Disease]]
==== Less common symptoms ====
[[Category:Hematology]]
*Less common symptoms of Hodgkin's lymphoma include the following:
[[Category:Types of cancer]]
:* Pain or feeling of fullness below the ribs due to swollen spleen or liver
[[Category:Rare diseases]]
:* Pain in lymph nodes after drinking alcohol
[[Category:Mature chapter]]
:* Skin blushing or [[flushing]]
[[Category:primary care]]
:* [[Bone pain]]
[[Category:Needs overview]]
:* Swelling of legs may be caused by extra fluid if swollen lymph nodes are blocking the flow of lymph fluid


{{WikiDoc Help Menu}}
==References==
{{WikiDoc Sources}}
<references />

Latest revision as of 04:00, 29 December 2018

Hodgkin's lymphoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hodgkin's lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray Findings

CT

MRI

Ultrasound

Biopsy

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hodgkin's lymphoma history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hodgkin's lymphoma history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hodgkin's lymphoma history and symptoms

CDC on Hodgkin's lymphoma history and symptoms

Hodgkin's lymphoma history and symptoms in the news

Blogs on Hodgkin's lymphoma history and symptoms

Directions to Hospitals Treating Hodgkin's lymphoma

Risk calculators and risk factors for Hodgkin's lymphoma history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Mohsen Basiri M.D.

Overview

The most common symptoms of classic Hodgkin lymphoma include painless localized peripheral lymphadenopathy, B symptoms (fever, night sweats, weight loss), and pruritus. Less common symptoms of Hodgkin lymphoma include cough, chest pain, breathing problems, pain or feeling of fullness below the ribs, pain in lymph nodes after drinking alcohol, skin blushing or flushing, bone pain, and leg swelling.

History and Symptoms

The presentation of Hodgkin lymphoma may vary depending on the location of tumor and organ involvement, mass size and stage of disease.[1][2][3]

History

  • Occasionally patients may present with nonspecific symptoms and signs that are more compatible with infection than malignant disease.
  • B symptoms or constitutional symptoms, include fever (>100.4°F), drenching night sweats, and unexplained weight loss (>10% of total body weight) may present up to 50 percent of patients with advanced disease.
  • Pruritus may be present before the diagnosis of Hodgkin lymphoma by months or even a year or more.

Symptoms

Common symptoms

  • Pruritus
  • Fatigue
  • Mediastinal mass effects include:
  • Chest pain
  • Cough
  • Shortness of breath

Less common symptoms

  • Less common symptoms of Hodgkin's lymphoma include the following:
  • Pain or feeling of fullness below the ribs due to swollen spleen or liver
  • Pain in lymph nodes after drinking alcohol
  • Skin blushing or flushing
  • Bone pain
  • Swelling of legs may be caused by extra fluid if swollen lymph nodes are blocking the flow of lymph fluid

References

  1. ↑ P. M. Mauch, L. A. Kalish, M. Kadin, C. N. Coleman, R. Osteen & S. Hellman (1993). "Patterns of presentation of Hodgkin disease. Implications for etiology and pathogenesis". Cancer. 71 (6): 2062–2071. PMID 8443755. Unknown parameter |month= ignored (help)
  2. ↑ Stephen M. Ansell (2015). "Hodgkin Lymphoma: Diagnosis and Treatment". Mayo Clinic proceedings. 90 (11): 1574–1583. doi:10.1016/j.mayocp.2015.07.005. PMID 26541251. Unknown parameter |month= ignored (help)
  3. ↑ P. G. Gobbi, C. Cavalli, A. Gendarini, A. Crema, G. Ricevuti, M. Federico, U. Di Prisco & E. Ascari (1985). "Reevaluation of prognostic significance of symptoms in Hodgkin's disease". Cancer. 56 (12): 2874–2880. PMID 4052959. Unknown parameter |month= ignored (help)
  4. ↑ G. R. Good & M. J. DiNubile (1995). "Images in clinical medicine. Cyclic fever in Hodgkin's disease (Pel-Ebstein fever)". The New England journal of medicine. 332 (7): 436. doi:10.1056/NEJM199502163320705. PMID 7824016. Unknown parameter |month= ignored (help)
Retrieved from "https://www.wikidoc.org/index.php?title=Hodgkin%27s_lymphoma_history_and_symptoms&oldid=1512835"