Gallbladder cancer diagnostic study of choice: Difference between revisions

Jump to navigation Jump to search
 
(7 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Gallbladder cancer}}
{{Gallbladder cancer}}
{{CMG}} {{VKG}}
{{CMG}}; {{AE}} {{VKG}}


==Overview==
==Overview==
There is no single diagnostic study of choice for the diagnosis of gallbladder cancer
There is no single diagnostic study of choice for the diagnosis of [[gallbladder cancer]]. According to Nevin's staging system and TNM [[Staging (pathology)|staging]] system of the American Joint Committee on Cancer there are several stages of [[gallbladder cancer]].


==Gallbladder cancer diagnostic study of choice==
==Gallbladder cancer diagnostic study of choice==
* There is no single diagnostic study of choice for the diagnosis of gallbladder cancer, but gallbladder cancer can be diagnosed based on ultrasound and computer tomography, Magnetic resonance imaging (MRI) and Positron emission tomography (PET)
* There is no single diagnostic study of choice for the diagnosis of [[gallbladder cancer]]
* [[Gallbladder|Gall bladder]] can be diagnosed based on:<ref name="pmid29262051">{{cite journal |vauthors=Jones MW, Ferguson T |title= |journal= |volume= |issue= |pages= |date= |pmid=29262051 |doi= |url=}}</ref>
** [[Ultrasound]]
** [[Computed tomography|Computer tomography]]  
** [[Magnetic resonance imaging]] ([[Magnetic resonance imaging|MRI]]) and
** [[Positron emission tomography]] ([[Positron emission tomography|PET]])  
 
===Staging===
 
* According to '''''Nevin's staging''''' system<ref name="pmid26421012">{{cite journal |vauthors=Kanthan R, Senger JL, Ahmed S, Kanthan SC |title=Gallbladder Cancer in the 21st Century |journal=J Oncol |volume=2015 |issue= |pages=967472 |year=2015 |pmid=26421012 |pmc=4569807 |doi=10.1155/2015/967472 |url=}}</ref><ref name="pmid16772780">{{cite journal |vauthors=Fong Y, Wagman L, Gonen M, Crawford J, Reed W, Swanson R, Pan C, Ritchey J, Stewart A, Choti M |title=Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database |journal=Ann. Surg. |volume=243 |issue=6 |pages=767–71; discussion 771–4 |year=2006 |pmid=16772780 |pmc=1570569 |doi=10.1097/01.sla.0000219737.81943.4e |url=}}</ref>
{| class="wikitable"
| style="background:#4479BA; color: #FFFFFF;" + |'''Stage'''       
| style="background:#4479BA; color: #FFFFFF;" + |'''Characteristics'''
|-
| style="background:#DCDCDC; + " | 1
|[[Invasion]] of [[mucosa]] by the [[tumor]]
|-
| style="background:#DCDCDC; + " | 2
|Invasion of mucosa and [[muscularis]] by the tumor
|-
| style="background:#DCDCDC; + " | 3
|Invasion of mucosa, muscularis, and  subserosa
|-
| style="background:#DCDCDC; + " | 4
|Involment of 3 layers of [[gallbladder]] + [[cystic]] [[lymph node]]
|-
| style="background:#DCDCDC; + " | 5
|[[Metastasis|metastases]]
|}
* According to '''''TNM''''' staging<ref name="pmid24854451">{{cite journal |vauthors=Shindoh J, de Aretxabala X, Aloia TA, Roa JC, Roa I, Zimmitti G, Javle M, Conrad C, Maru DM, Aoki T, Vigano L, Ribero D, Kokudo N, Capussotti L, Vauthey JN |title=Tumor location is a strong predictor of tumor progression and survival in T2 gallbladder cancer: an international multicenter study |journal=Ann. Surg. |volume=261 |issue=4 |pages=733–9 |year=2015 |pmid=24854451 |pmc=4800978 |doi=10.1097/SLA.0000000000000728 |url=}}</ref><ref name="pmid23964151">{{cite journal |vauthors=Liu GJ, Li XH, Chen YX, Sun HD, Zhao GM, Hu SY |title=Radical lymph node dissection and assessment: Impact on gallbladder cancer prognosis |journal=World J. Gastroenterol. |volume=19 |issue=31 |pages=5150–8 |year=2013 |pmid=23964151 |pmc=3746389 |doi=10.3748/wjg.v19.i31.5150 |url=}}</ref>
{| class="wikitable"
! style="background:#4479BA; color: #FFFFFF;" + | Stage
! style="background:#4479BA; color: #FFFFFF;" + | T-Stage
! style="background:#4479BA; color: #FFFFFF;" + | N-Stage
! style="background:#4479BA; color: #FFFFFF;" + | M-Stage
|-
| style="background:#DCDCDC; + " | 0
|Tis<sup>♣</sup>
|N0'''<sup>ɸ</sup>'''
|M0'''<sup>ɝ</sup>'''
|-
| style="background:#DCDCDC; + " | 1
|T1<sup>'''†'''</sup>
|N0
|M0
|-
| style="background:#DCDCDC; + " |
|T1a
|
|
|-
| style="background:#DCDCDC; + " |
|T1b
|
|
|-
| style="background:#DCDCDC; + " | 2
|T2<sup>'''¥'''</sup>
|N0
|M0
|-
| style="background:#DCDCDC; + " |
|T2a
|
|
|-
| style="background:#DCDCDC; + " |
|T2b
|
|
|-
| style="background:#DCDCDC; + " | 3A
|T3<sup>'''♠'''</sup>
|N0
|M0
|-
| style="background:#DCDCDC; + " | 3B
|T1,T2,T3
|N1<sup>ǂ</sup>
|M0
|-
| style="background:#DCDCDC; + " | 4A
|T4<sup>'''♦'''</sup>
|N0,N1
|M0
|-
| style="background:#DCDCDC; + " | 5B
|Any T
|Any N
|M1<sup>'''ɚ'''</sup>
|}
''♣'''='''Tis [[Carcinoma]] [[in situ]];'''†''' T1a-[[Tumor]] invades the [[lamina propria]]; T1b-Tumor invades the [[muscular]] layer; '''¥='''T2 Tumour invades perimuscular [[connective tissue]]; T2a-Tumor invades the perimuscular connective tissue without involvement of the [[serosa]]; T2b-Tumor invades the perimuscular connective tissue with no [[extension]] into the [[liver]];'''♠=''' T3 Tumour perforates serosa and/or invades liver and/or other adjacent organs; '''♦='''T4 Tumour invades main [[portal vein]] or [[hepatic artery]] or multiple extrahepatic organs.''
 
'''''ɸ=''' N0-No regional lymph node metastasis;'''ǂ='''N1- Metastases to one or three regional lymph nodes;''
 
'''''ɝ='''M0-No distant [[metastasis]];'''ɚ='''M1-Distant metastasis''
 


==References==
==References==


{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 17:02, 4 January 2019

Gallbladder cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Screening

Differentiating Gallbladder cancer from other Diseases

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

CT

MRI

Echocardiography and Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Palliative Treatment

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Gallbladder cancer diagnostic study of choice On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Gallbladder cancer diagnostic study of choice

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Gallbladder cancer diagnostic study of choice

CDC on Gallbladder cancer diagnostic study of choice

Gallbladder cancer diagnostic study of choice in the news

Blogs on Gallbladder cancer diagnostic study of choice

Directions to Hospitals Treating Gallbladder cancer

Risk calculators and risk factors for Gallbladder cancer diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

There is no single diagnostic study of choice for the diagnosis of gallbladder cancer. According to Nevin's staging system and TNM staging system of the American Joint Committee on Cancer there are several stages of gallbladder cancer.

Gallbladder cancer diagnostic study of choice

Staging

  • According to Nevin's staging system[2][3]
Stage Characteristics
1 Invasion of mucosa by the tumor
2 Invasion of mucosa and muscularis by the tumor
3 Invasion of mucosa, muscularis, and subserosa
4 Involment of 3 layers of gallbladder + cystic lymph node
5 metastases
  • According to TNM staging[4][5]
Stage T-Stage N-Stage M-Stage
0 Tis N0ɸ M0ɝ
1 T1 N0 M0
T1a
T1b
2 T2¥ N0 M0
T2a
T2b
3A T3 N0 M0
3B T1,T2,T3 N1ǂ M0
4A T4 N0,N1 M0
5B Any T Any N M1ɚ

=Tis Carcinoma in situ; T1a-Tumor invades the lamina propria; T1b-Tumor invades the muscular layer; ¥=T2 Tumour invades perimuscular connective tissue; T2a-Tumor invades the perimuscular connective tissue without involvement of the serosa; T2b-Tumor invades the perimuscular connective tissue with no extension into the liver;♠= T3 Tumour perforates serosa and/or invades liver and/or other adjacent organs; ♦=T4 Tumour invades main portal vein or hepatic artery or multiple extrahepatic organs.

ɸ= N0-No regional lymph node metastasis;ǂ=N1- Metastases to one or three regional lymph nodes;

ɝ=M0-No distant metastasis;ɚ=M1-Distant metastasis


References

  1. Jones MW, Ferguson T. PMID 29262051. Missing or empty |title= (help)
  2. Kanthan R, Senger JL, Ahmed S, Kanthan SC (2015). "Gallbladder Cancer in the 21st Century". J Oncol. 2015: 967472. doi:10.1155/2015/967472. PMC 4569807. PMID 26421012.
  3. Fong Y, Wagman L, Gonen M, Crawford J, Reed W, Swanson R, Pan C, Ritchey J, Stewart A, Choti M (2006). "Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database". Ann. Surg. 243 (6): 767–71, discussion 771–4. doi:10.1097/01.sla.0000219737.81943.4e. PMC 1570569. PMID 16772780.
  4. Shindoh J, de Aretxabala X, Aloia TA, Roa JC, Roa I, Zimmitti G, Javle M, Conrad C, Maru DM, Aoki T, Vigano L, Ribero D, Kokudo N, Capussotti L, Vauthey JN (2015). "Tumor location is a strong predictor of tumor progression and survival in T2 gallbladder cancer: an international multicenter study". Ann. Surg. 261 (4): 733–9. doi:10.1097/SLA.0000000000000728. PMC 4800978. PMID 24854451.
  5. Liu GJ, Li XH, Chen YX, Sun HD, Zhao GM, Hu SY (2013). "Radical lymph node dissection and assessment: Impact on gallbladder cancer prognosis". World J. Gastroenterol. 19 (31): 5150–8. doi:10.3748/wjg.v19.i31.5150. PMC 3746389. PMID 23964151.