ZFY: Difference between revisions

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Latest revision as of 08:11, 9 January 2019

Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome.^[1]^[2]

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.^[2]

References

↑ Muller G, Schempp W (Jun 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Hum Genet. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060.
↑ ^2.0 ^2.1 "Entrez Gene: ZFY zinc finger protein, Y-linked".

Merchant-Larios H, Moreno-Mendoza N (2002). "Onset of sex differentiation: dialog between genes and cells". Arch. Med. Res. 32 (6): 553–8. doi:10.1016/S0188-4409(01)00317-4. PMID 11750730.
Kochoyan M, Havel TF, Nguyen DT, et al. (1991). "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition". Biochemistry. 30 (14): 3371–86. doi:10.1021/bi00228a004. PMID 1849423.
Kochoyan M, Keutmann HT, Weiss MA (1991). "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition". Biochemistry. 30 (29): 7063–72. doi:10.1021/bi00243a005. PMID 1854720.
North M, Sargent C, O'Brien J, et al. (1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY". Nucleic Acids Res. 19 (10): 2579–86. doi:10.1093/nar/19.10.2579. PMC 328173. PMID 2041734.
Palmer MS, Berta P, Sinclair AH, et al. (1990). "Comparison of human ZFY and ZFX transcripts". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1681–5. doi:10.1073/pnas.87.5.1681. PMC 53546. PMID 2308929.
Affara NA, Chambers D, O'Brien J, et al. (1989). "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9". Nucleic Acids Res. 17 (8): 2987–99. doi:10.1093/nar/17.8.2987. PMC 317707. PMID 2498838.
Lau YF, Chan KM (1990). "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues". Am. J. Hum. Genet. 45 (6): 942–52. PMC 1683462. PMID 2511751.
Page DC, Mosher R, Simpson EM, et al. (1988). "The sex-determining region of the human Y chromosome encodes a finger protein". Cell. 51 (6): 1091–104. doi:10.1016/0092-8674(87)90595-2. PMID 3690661.
Tricoli JV, Bracken RB (1993). "ZFY gene expression and retention in human prostate adenocarcinoma". Genes Chromosomes Cancer. 6 (2): 65–72. doi:10.1002/gcc.2870060202. PMID 7680890.
Erlandsson R, Wilson JF, Pääbo S (2000). "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans". Mol. Biol. Evol. 17 (5): 804–12. doi:10.1093/oxfordjournals.molbev.a026359. PMID 10779541.
Mittwoch U (2001). "Three thousand years of questioning sex determination". Cytogenet. Cell Genet. 91 (1–4): 186–91. doi:10.1159/000056842. PMID 11173854.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid2497060-1] Muller G, Schempp W (Jun 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Hum Genet. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060.

[entrez-2] 2.0 ^2.1 "Entrez Gene: ZFY zinc finger protein, Y-linked".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{notability|date=June 2017}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Zinc finger Y-chromosomal protein''' is a [[protein]] that in humans is encoded by the ''ZFY'' [[gene]] of the [[Y chromosome]].<ref name="pmid2497060">{{cite journal | vauthors = Muller G, Schempp W | title = Mapping the human ZFX locus to Xp21.3 by in situ hybridization | journal = Hum Genet | volume = 82 | issue = 1 | pages = 82–4 |date=Jun 1989 | pmid = 2497060 | pmc =  | doi =10.1007/BF00288279  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZFY zinc finger protein, Y-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7544| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_ZFY_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1klr.
- | PDB = {{PDB2|1klr}}, {{PDB2|5znf}}
- | Name = Zinc finger protein, Y-linked
- | HGNCid = 12870
- | Symbol = ZFY
- | AltSymbols =; MGC138710
- | OMIM = 490000
- | ECnumber =
- | Homologene = 88465
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_ZFY_207247_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_ZFY_207246_at_tn.png
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7544
-    | Hs_Ensembl = ENSG00000067646
-    | Hs_RefseqProtein = NP_003402
-    | Hs_RefseqmRNA = NM_003411
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = Y
-    | Hs_GenLoc_start = 2863322
-    | Hs_GenLoc_end = 2910547
-    | Hs_Uniprot = P08048
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Zinc finger protein, Y-linked''', also known as '''ZFY''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZFY zinc finger protein, Y-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7544| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.<ref name="entrez">{{cite web | title = Entrez Gene: ZFY zinc finger protein, Y-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7544| accessdate = }}</ref>
+| summary_text = This gene encodes a [[zinc finger]]-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+==Further reading==<!-- CytogenetGenomeRes101:266. -->
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Merchant-Larios H, Moreno-Mendoza N |title=Onset of sex differentiation: dialog between genes and cells. |journal=Arch. Med. Res. |volume=32 |issue= 6 |pages= 553-8 |year= 2002 |pmid= 11750730 |doi=  }}
+*{{cite journal  | vauthors=Merchant-Larios H, Moreno-Mendoza N |title=Onset of sex differentiation: dialog between genes and cells |journal=Arch. Med. Res. |volume=32 |issue= 6 |pages= 553–8 |year= 2002 |pmid= 11750730 |doi=10.1016/S0188-4409(01)00317-4  }}
-*{{cite journal  | author=Kochoyan M, Havel TF, Nguyen DT, ''et al.'' |title=Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition. |journal=Biochemistry |volume=30 |issue= 14 |pages= 3371-86 |year= 1991 |pmid= 1849423 |doi=  }}
+*{{cite journal   |vauthors=Kochoyan M, Havel TF, Nguyen DT, etal |title=Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition |journal=Biochemistry |volume=30 |issue= 14 |pages= 3371–86 |year= 1991 |pmid= 1849423 |doi=10.1021/bi00228a004  }}
-*{{cite journal  | author=Kochoyan M, Keutmann HT, Weiss MA |title=Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition. |journal=Biochemistry |volume=30 |issue= 29 |pages= 7063-72 |year= 1991 |pmid= 1854720 |doi=  }}
+*{{cite journal  | vauthors=Kochoyan M, Keutmann HT, Weiss MA |title=Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition |journal=Biochemistry |volume=30 |issue= 29 |pages= 7063–72 |year= 1991 |pmid= 1854720 |doi=10.1021/bi00243a005  }}
-*{{cite journal  | author=North M, Sargent C, O'Brien J, ''et al.'' |title=Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. |journal=Nucleic Acids Res. |volume=19 |issue= 10 |pages= 2579-86 |year= 1991 |pmid= 2041734 |doi=  }}
+*{{cite journal   |vauthors=North M, Sargent C, O'Brien J, etal |title=Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY |journal=Nucleic Acids Res. |volume=19 |issue= 10 |pages= 2579–86 |year= 1991 |pmid= 2041734 |doi=10.1093/nar/19.10.2579  | pmc=328173  }}
-*{{cite journal  | author=Palmer MS, Berta P, Sinclair AH, ''et al.'' |title=Comparison of human ZFY and ZFX transcripts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 5 |pages= 1681-5 |year= 1990 |pmid= 2308929 |doi=  }}
+*{{cite journal   |vauthors=Palmer MS, Berta P, Sinclair AH, etal |title=Comparison of human ZFY and ZFX transcripts |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 5 |pages= 1681–5 |year= 1990 |pmid= 2308929 |doi=10.1073/pnas.87.5.1681  | pmc=53546  }}
-*{{cite journal  | author=Müller G, Schempp W |title=Mapping the human ZFX locus to Xp21.3 by in situ hybridization. |journal=Hum. Genet. |volume=82 |issue= 1 |pages= 82-4 |year= 1989 |pmid= 2497060 |doi=  }}
+*{{cite journal   |vauthors=Affara NA, Chambers D, O'Brien J, etal |title=Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9 |journal=Nucleic Acids Res. |volume=17 |issue= 8 |pages= 2987–99 |year= 1989 |pmid= 2498838 |doi=10.1093/nar/17.8.2987  | pmc=317707  }}
-*{{cite journal  | author=Affara NA, Chambers D, O'Brien J, ''et al.'' |title=Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9. |journal=Nucleic Acids Res. |volume=17 |issue= 8 |pages= 2987-99 |year= 1989 |pmid= 2498838 |doi=  }}
+*{{cite journal  | vauthors=Lau YF, Chan KM |title=The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues |journal=Am. J. Hum. Genet. |volume=45 |issue= 6 |pages= 942–52 |year= 1990 |pmid= 2511751 |doi=  | pmc=1683462  }}
-*{{cite journal  | author=Lau YF, Chan KM |title=The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. |journal=Am. J. Hum. Genet. |volume=45 |issue= 6 |pages= 942-52 |year= 1990 |pmid= 2511751 |doi=  }}
+*{{cite journal   |vauthors=Page DC, Mosher R, Simpson EM, etal |title=The sex-determining region of the human Y chromosome encodes a finger protein |journal=Cell |volume=51 |issue= 6 |pages= 1091–104 |year= 1988 |pmid= 3690661 |doi=10.1016/0092-8674(87)90595-2  }}
-*{{cite journal  | author=Page DC, Mosher R, Simpson EM, ''et al.'' |title=The sex-determining region of the human Y chromosome encodes a finger protein. |journal=Cell |volume=51 |issue= 6 |pages= 1091-104 |year= 1988 |pmid= 3690661 |doi=  }}
+*{{cite journal  | vauthors=Tricoli JV, Bracken RB |title=ZFY gene expression and retention in human prostate adenocarcinoma |journal=Genes Chromosomes Cancer |volume=6 |issue= 2 |pages= 65–72 |year= 1993 |pmid= 7680890 |doi=10.1002/gcc.2870060202  }}
-*{{cite journal  | author=Tricoli JV, Bracken RB |title=ZFY gene expression and retention in human prostate adenocarcinoma. |journal=Genes Chromosomes Cancer |volume=6 |issue= 2 |pages= 65-72 |year= 1993 |pmid= 7680890 |doi=  }}
+*{{cite journal  | vauthors=Erlandsson R, Wilson JF, Pääbo S |title=Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans |journal=Mol. Biol. Evol. |volume=17 |issue= 5 |pages= 804–12 |year= 2000 |pmid= 10779541 |doi=  10.1093/oxfordjournals.molbev.a026359}}
-*{{cite journal  | author=Erlandsson R, Wilson JF, Pääbo S |title=Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. |journal=Mol. Biol. Evol. |volume=17 |issue= 5 |pages= 804-12 |year= 2000 |pmid= 10779541 |doi=  }}
+*{{cite journal  | author=Mittwoch U |title=Three thousand years of questioning sex determination |journal=Cytogenet. Cell Genet. |volume=91 |issue= 1–4 |pages= 186–91 |year= 2001 |pmid= 11173854 |doi=10.1159/000056842  }}
-*{{cite journal  | author=Mittwoch U |title=Three thousand years of questioning sex determination. |journal=Cytogenet. Cell Genet. |volume=91 |issue= 1-4 |pages= 186-91 |year= 2001 |pmid= 11173854 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, etal |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes |journal=Nature |volume=423 |issue= 6942 |pages= 825–37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 }}
-*{{cite journal  | author=Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, ''et al.'' |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. |journal=Nature |volume=423 |issue= 6942 |pages= 825-37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 }}
+*{{cite journal  | vauthors=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384–96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027 }}
-*{{cite journal  | author=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384-96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=7544}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+[[Category:Genes on human chromosome Y]]
 {{protein-stub}}
-{{WikiDoc Sources}}

ZFY: Difference between revisions

Latest revision as of 08:11, 9 January 2019

References

Further reading

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