MIR187: Difference between revisions

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{{Underlinked|date=April 2014}}
{{Infobox_gene}}
{{Infobox_gene}}
'''MicroRNA 187''' is a [[protein]] that in humans is encoded by the MIR187 [[gene]].<ref name="entrez">{{cite web
| title = Entrez Gene: MicroRNA 187 | url = https://www.ncbi.nlm.nih.gov/gene/406963 }}</ref>


'''MicroRNA 187''' is a [[protein]] that in humans is encoded by the MIR187 [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: MicroRNA 187
| url = https://www.ncbi.nlm.nih.gov/gene/406963
| accessdate = 2013-12-05 <!-- T05:29:26.764977-08:00 -->
}}</ref>


==Function==
[[microRNA]]s (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of [[mRNA]]s. miRNAs are transcribed by [[RNA polymerase II]] as part of capped and [[polyadenylation|polyadenylated]] primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the [[Drosha]] ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic [[Dicer]] [[ribonuclease]] to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a [[RNA-induced silencing complex]] (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA.
 
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal  
* {{cite journal | vauthors = Rossato M, Curtale G, Tamassia N, Castellucci M, Mori L, Gasperini S, Mariotti B, De Luca M, Mirolo M, Cassatella MA, Locati M, Bazzoni F | title = IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 45 | pages = E3101-10 | date = November 2012 | pmid = 23071313 | pmc = 3494907 | doi = 10.1073/pnas.1209100109 | url = https://air.unimi.it/bitstream/2434/252105/2/pnas.201209100.pdf }}
| last1 = Rossato | first1 = M.
* {{cite journal | vauthors = Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP | title = Vertebrate microRNA genes | journal = Science | volume = 299 | issue = 5612 | pages = 1540 | date = March 2003 | pmid = 12624257 | pmc = | doi = 10.1126/science.1080372 }}
| last2 = Curtale | first2 = G.
* {{cite journal | vauthors = Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G | title = Numerous microRNPs in neuronal cells containing novel microRNAs | journal = RNA | volume = 9 | issue = 2 | pages = 180–6 | date = February 2003 | pmid = 12554860 | pmc = 1370383 | doi = 10.1261/rna.2141503 }}
| last3 = Tamassia | first3 = N.
* {{cite journal | vauthors = Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, Hsueh S, Wu TI, Tsai CN, Wang CJ, Chao AS, Wang TH, Lai CH | title = Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2 | journal = Oncogene | volume = 31 | issue = 6 | pages = 764–75 | date = February 2012 | pmid = 21725366 | pmc = | doi = 10.1038/onc.2011.269 }}
| last4 = Castellucci | first4 = M.
* {{cite journal | vauthors = Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM, O'Connor DP | title = miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro | journal = Clinical Cancer Research | volume = 18 | issue = 24 | pages = 6702–13 | date = December 2012 | pmid = 23060431 | pmc = | doi = 10.1158/1078-0432.CCR-12-1420 }}
| last5 = Mori | first5 = L.
| last6 = Gasperini | first6 = S.
| last7 = Mariotti | first7 = B.
| last8 = De Luca | first8 = M.
| last9 = Mirolo | first9 = M.
| last10 = Cassatella | first10 = M. A.
| last11 = Locati | first11 = M.
| last12 = Bazzoni | first12 = F.
| doi = 10.1073/pnas.1209100109
| title = IL-10-induced microRNA-187 negatively regulates TNF- , IL-6, and IL-12p40 production in TLR4-stimulated monocytes  
| journal = Proceedings of the National Academy of Sciences  
| volume = 109  
| issue = 45  
| pages = E3101–E3110
| year = 2012  
| pmid = 23071313  
| pmc =3494907  
}}
*{{Cite journal  
| last1 = Lim | first1 = L. P.
| last2 = Glasner | first2 = M. E.
| last3 = Yekta | first3 = S.
| last4 = Burge | first4 = C. B.
| last5 = Bartel | first5 = D. P.
| title = Vertebrate MicroRNA Genes
| doi = 10.1126/science.1080372
| journal = Science  
| volume = 299  
| issue = 5612  
| pages = 1540  
| year = 2003  
| pmid = 12624257  
| pmc =  
}}
*{{Cite journal  
| last1 = Dostie | first1 = J.
| last2 = Mourelatos | first2 = Z.
| last3 = Yang | first3 = M.
| last4 = Sharma | first4 = A.
| last5 = Dreyfuss | first5 = G.
| title = Numerous microRNPs in neuronal cells containing novel microRNAs  
| journal = RNA  
| volume = 9  
| issue = 2  
| pages = 180–186
| year = 2003  
| pmid = 12554860  
| pmc = 1370383  
| doi = 10.1261/rna.2141503
}}
*{{Cite journal  
| last1 = Chao | first1 = A.
| last2 = Lin | first2 = C. -Y.
| last3 = Lee | first3 = Y. -S.
| last4 = Tsai | first4 = C. -L.
| last5 = Wei | first5 = P. -C.
| last6 = Hsueh | first6 = S.
| last7 = Wu | first7 = T. -I.
| last8 = Tsai | first8 = C. -N.
| last9 = Wang | first9 = C. -J.
| last10 = Chao  
| doi = 10.1038/onc.2011.269 | first10 = A. -S.
| last11 = Wang | first11 = T. -H.
| last12 = Lai | first12 = C. -H.
| title = Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2  
| journal = Oncogene  
| volume = 31  
| issue = 6  
| pages = 764–775
| year = 2011
| pmid = 21725366  
| pmc =  
}}
*{{Cite journal  
| last1 = Mulrane | first1 = L.
| last2 = Madden | first2 = S. F.
| last3 = Brennan | first3 = D. J.
| last4 = Gremel | first4 = G.
| last5 = McGee | first5 = S. F.
| last6 = McNally | first6 = S.
| last7 = Martin | first7 = F.
| last8 = Crown | first8 = J. P.
| last9 = Jirström | first9 = K.
| last10 = Higgins | first10 = D. G.
| last11 = Gallagher | first11 = W. M.
| last12 = O'Connor | first12 = D. P.
| doi = 10.1158/1078-0432.CCR-12-1420
| title = MiR-187 is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential in Vitro
| journal = Clinical Cancer Research  
| volume = 18  
| issue = 24  
| pages = 6702–6713
| year = 2012  
| pmid = 23060431  
| pmc =  
}}
 
{{refend}}
{{refend}}


Latest revision as of 08:59, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MicroRNA 187 is a protein that in humans is encoded by the MIR187 gene.[1]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA.

References

  1. ↑ "Entrez Gene: MicroRNA 187".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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