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| doi = 10.1371/journal.pone.0115029
| doi = 10.1371/journal.pone.0115029
| bibcode = 2014PLoSO...9k5029L
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==Interactions==
==Interactions==
RIT2 has been shown to [[Protein-protein interaction|interact]] with [[POU4F1]].<ref name=pmid12934100>{{cite journal |last=Calissano |first=M |authorlink= |author2=Latchman D S  |date=Aug 2003 |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor |journal=Oncogene |volume=22 |issue=35 |pages=5408–14 |publisher= |location = England| issn = 0950-9232| pmid = 12934100 |doi = 10.1038/sj.onc.1206635 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
RIT2 has been shown to [[Protein-protein interaction|interact]] with [[POU4F1]].<ref name=pmid12934100>{{cite journal |last=Calissano |first=M |authorlink= |author2=Latchman D S  |date=Aug 2003 |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor |journal=Oncogene |volume=22 |issue=35 |pages=5408–14 | issn = 0950-9232| pmid = 12934100 |doi = 10.1038/sj.onc.1206635 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
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*{{cite journal  |vauthors=Shao H, Kadono-Okuda K, Finlin BS, Andres DA |title=Biochemical characterization of the Ras-related GTPases Rit and Rin. |journal=Arch. Biochem. Biophys. |volume=371 |issue= 2 |pages= 207–19 |year= 1999 |pmid= 10545207 |doi= 10.1006/abbi.1999.1448 }}
*{{cite journal  |vauthors=Shao H, Kadono-Okuda K, Finlin BS, Andres DA |title=Biochemical characterization of the Ras-related GTPases Rit and Rin. |journal=Arch. Biochem. Biophys. |volume=371 |issue= 2 |pages= 207–19 |year= 1999 |pmid= 10545207 |doi= 10.1006/abbi.1999.1448 }}
*{{cite journal  |vauthors=Hoshino M, Nakamura S |title=The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 3 |pages= 651–6 |year= 2002 |pmid= 12099688 |doi=10.1016/S0006-291X(02)00731-3  }}
*{{cite journal  |vauthors=Hoshino M, Nakamura S |title=The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 3 |pages= 651–6 |year= 2002 |pmid= 12099688 |doi=10.1016/S0006-291X(02)00731-3  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Calissano M, Latchman DS |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. |journal=Oncogene |volume=22 |issue= 35 |pages= 5408–14 |year= 2003 |pmid= 12934100 |doi= 10.1038/sj.onc.1206635 }}
*{{cite journal  |vauthors=Calissano M, Latchman DS |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. |journal=Oncogene |volume=22 |issue= 35 |pages= 5408–14 |year= 2003 |pmid= 12934100 |doi= 10.1038/sj.onc.1206635 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Hartwig C, Veske A, Krejcova S, etal |title=Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. |journal=BMC Neuroscience |volume=6|pages= 53 |year= 2006 |pmid= 16122393 |doi= 10.1186/1471-2202-6-53  | pmc=1215486 }}
*{{cite journal  |vauthors=Hartwig C, Veske A, Krejcova S, etal |title=Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. |journal=BMC Neuroscience |volume=6|pages= 53 |year= 2006 |pmid= 16122393 |doi= 10.1186/1471-2202-6-53  | pmc=1215486 }}
*{{cite journal  |vauthors=Shi GX, Han J, Andres DA |title=Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37599–609 |year= 2006 |pmid= 16157584 |doi= 10.1074/jbc.M507364200 }}
*{{cite journal  |vauthors=Shi GX, Han J, Andres DA |title=Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37599–609 |year= 2006 |pmid= 16157584 |doi= 10.1074/jbc.M507364200 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
}}
}}
{{refend}}
{{refend}}

Latest revision as of 09:05, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.[1][2][3]

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM][3]

RIT2 has been associated with Parkinson's disease in two large genetic studies.[4][5] An gene expression study of postmortem brain has suggested RIT2 interacts with interferon-γ signalling.[6]

Interactions

RIT2 has been shown to interact with POU4F1.[7]

References

  1. ↑ Lee CH, Della NG, Chew CE, Zack DJ (Nov 1996). "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". J Neurosci. 16 (21): 6784–94. PMID 8824319.
  2. ↑ Wes PD, Yu M, Montell C (Jan 1997). "RIC, a calmodulin-binding Ras-like GTPase". EMBO J. 15 (21): 5839–48. PMC 452332. PMID 8918462.
  3. ↑ 3.0 3.1 "Entrez Gene: RIT2 Ras-like without CAAX 2".
  4. ↑ Pankratz, N; Beecham, G. W.; Destefano, A. L.; Dawson, T. M.; Doheny, K. F.; Factor, S. A.; Hamza, T. H.; Hung, A. Y.; Hyman, B. T.; Ivinson, A. J.; Krainc, D; Latourelle, J. C.; Clark, L. N.; Marder, K; Martin, E. R.; Mayeux, R; Ross, O. A.; Scherzer, C. R.; Simon, D. K.; Tanner, C; Vance, J. M.; Wszolek, Z. K.; Zabetian, C. P.; Myers, R. H.; Payami, H; Scott, W. K.; Foroud, T; Pd Gwas, Consortium (2012). "Meta-analysis of Parkinson's disease: Identification of a novel locus, RIT2". Annals of Neurology. 71 (3): 370–84. doi:10.1002/ana.22687. PMC 3354734. PMID 22451204.
  5. ↑ Nalls, M. A.; Pankratz, N; Lill, C. M.; Do, C. B.; Hernandez, D. G.; Saad, M; Destefano, A. L.; Kara, E; Bras, J; Sharma, M; Schulte, C; Keller, M. F.; Arepalli, S; Letson, C; Edsall, C; Stefansson, H; Liu, X; Pliner, H; Lee, J. H.; Cheng, R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); Hadjigeorgiou, Georgios M; Bis, Joshua C; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); et al. (2014). "Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease". Nature Genetics. 46 (9): 989–93. doi:10.1038/ng.3043. PMC 4146673. PMID 25064009.
  6. ↑ Liscovitch, N; French, L (2014). "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease". PLoS ONE. 9 (12): e115029. Bibcode:2014PLoSO...9k5029L. doi:10.1371/journal.pone.0115029. PMC 4262449. PMID 25493648.
  7. ↑ Calissano, M; Latchman D S (Aug 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. ISSN 0950-9232. PMID 12934100.

Further reading



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