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{{Infobox_gene}}
{{GNF_Protein_box
'''Ribosomal RNA processing protein 1 homolog A''' is a [[protein]] that in humans is encoded by the ''RRP1'' [[gene]].<ref name="pmid10830953">{{cite journal | vauthors = Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML | title = The DNA sequence of human chromosome 21 | journal = Nature | volume = 405 | issue = 6784 | pages = 311–9 |date=Jun 2000 | pmid = 10830953 | pmc =  | doi = 10.1038/35012518 }}</ref><ref name="pmid10341208">{{cite journal | vauthors = Savino TM, Bastos R, Jansen E, Hernandez-Verdun D | title = The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis | series = 112 | journal = J Cell Sci | volume = ( Pt 12) | issue =  | pages = 1889–900 |date=Aug 1999 | pmid = 10341208 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8568| accessdate = }}</ref>
| image =
| image_source = 
| PDB =
| Name = DNA segment on chromosome 21 (unique) 2056 expressed sequence
| HGNCid =
| Symbol = D21S2056E
| AltSymbols =; NNP-1; NOP52
| OMIM = 610653
| ECnumber =
| Homologene = 55771
| MGIid = 1203500
  | GeneAtlas_image1 = PBB_GE_D21S2056E_218758_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004784 |text = superoxide dismutase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030688 |text = nucleolar preribosome, small subunit precursor}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}} {{GNF_GO|id=GO:0006801 |text = superoxide metabolic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8568
    | Hs_Ensembl = ENSG00000160214
    | Hs_RefseqProtein = NP_003674
    | Hs_RefseqmRNA = NM_003683
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 44033859
    | Hs_GenLoc_end = 44049585
    | Hs_Uniprot = P56182
    | Mm_EntrezGene = 18114
    | Mm_Ensembl = ENSMUSG00000061032
    | Mm_RefseqmRNA = NM_010925
    | Mm_RefseqProtein = NP_035055
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 77803513
    | Mm_GenLoc_end = 77816134
    | Mm_Uniprot = Q05CN2
  }}
}}
'''DNA segment on chromosome 21 (unique) 2056 expressed sequence''', also known as '''D21S2056E''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8568| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA.<ref name="entrez">{{cite web | title = Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8568| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is the putative [[homolog]] of the yeast [[ribosomal RNA]] processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of [[mitosis]], and may be required for the generation of 28S rRNA.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Jansen E, Meulemans SM, Orlans IC, Van de Ven WJ |title=The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3. |journal=Genomics |volume=42 |issue= 2 |pages= 336-41 |year= 1997 |pmid= 9192856 |doi= 10.1006/geno.1997.4755 }}
*{{cite journal  | vauthors=Jansen E, Meulemans SM, Orlans IC, Van de Ven WJ |title=The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3. |journal=Genomics |volume=42 |issue= 2 |pages= 336–41 |year= 1997 |pmid= 9192856 |doi= 10.1006/geno.1997.4755 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Savino TM, Bastos R, Jansen E, Hernandez-Verdun D |title=The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis. |journal=J. Cell. Sci. |volume=112 ( Pt 12) |issue=  |pages= 1889-900 |year= 1999 |pmid= 10341208 |doi= }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal   |vauthors=Behrends U, Jandl T, Golbeck A, etal |title=Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. |journal=Int. J. Cancer |volume=100 |issue= 6 |pages= 669–77 |year= 2002 |pmid= 12209604 |doi= 10.1002/ijc.10550 }}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal   |vauthors=Scherl A, Couté Y, Déon C, etal |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 }}
*{{cite journal | author=Behrends U, Jandl T, Golbeck A, ''et al.'' |title=Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. |journal=Int. J. Cancer |volume=100 |issue= 6 |pages= 669-77 |year= 2002 |pmid= 12209604 |doi= 10.1002/ijc.10550 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Hu YH, Warnatz HJ, Vanhecke D, etal |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. |journal=BMC Genomics |volume=7|pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155 | pmc=1526728 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Hu YH, Warnatz HJ, Vanhecke D, ''et al.'' |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. |journal=BMC Genomics |volume=7 |issue=  |pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155 }}
}}
}}
{{refend}}
{{refend}}
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{{gene-21-stub}}
{{gene-21-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:11, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ribosomal RNA processing protein 1 homolog A is a protein that in humans is encoded by the RRP1 gene.[1][2][3]

The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA.[3]

References

  1. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  2. Savino TM, Bastos R, Jansen E, Hernandez-Verdun D (Aug 1999). "The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis". J Cell Sci. 112. ( Pt 12): 1889–900. PMID 10341208.
  3. 3.0 3.1 "Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence".

Further reading