CKAP2: Difference between revisions

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'''Cytoskeleton-associated protein 2''' is a [[protein]] that in humans is encoded by the ''CKAP2'' [[gene]].<ref name="pmid9771967">{{cite journal | vauthors = Maouche-Chretien L, Deleu N, Badoual C, Fraissignes P, Berger R, Gaulard P, Romeo PH, Leroy-Viard K | title = Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas | journal = Oncogene | volume = 17 | issue = 10 | pages = 1245–51 |date=Oct 1998 | pmid = 9771967 | pmc =  | doi = 10.1038/sj.onc.1202048 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CKAP2 cytoskeleton associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26586| accessdate = }}</ref>
'''Cytoskeleton-associated protein 2''' is a [[protein]] that in humans is encoded by the ''CKAP2'' [[gene]].<ref name="pmid9771967">{{cite journal | vauthors = Maouche-Chretien L, Deleu N, Badoual C, Fraissignes P, Berger R, Gaulard P, Romeo PH, Leroy-Viard K | title = Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas | journal = Oncogene | volume = 17 | issue = 10 | pages = 1245–51 |date=Oct 1998 | pmid = 9771967 | pmc =  | doi = 10.1038/sj.onc.1202048 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CKAP2 cytoskeleton associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26586| accessdate = }}</ref>
Human CKAP2 gene, the [[Complementary DNA|cDNA]] of which is known as LB1, is a [[cytoskeleton]]-associated protein involved in [[mitotic]] progression. Its high transcriptional activity has been observed in the [[Testicle|testes]], [[thymus]], and diffuse [[Lymphoma|B-cell lymphomas]]. The gene codes for a protein of 683 residues, which lacks a [[homology modeling|homology]] to known amino acid sequences. On evidence of [[immunofluorescence]] analysis, the CKAP2 product is a [[cytoplasmic]] protein associated with cytoskeletal fibrils.
The CKAP2 gene is in [[chromosome 13]]q14. Rearrangements of this region result in various tumors. Thus deletions have been detected in [[multiple myeloma]], [[prostate cancer]], [[Head and neck squamous-cell carcinoma|head-and-neck squamous-cell carcinoma]], [[B-cell prolymphocytic leukemia]], [[non-Hodgkin lymphoma]], and in more than half cases of [[B-cell chronic lymphocytic leukemia]].


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Alternative titles: TUMOR- AND MICROTUBLE-ASSOCIATED PROTEIN; TMAP, LB1
Alternative titles: TUMOR- AND MICROTUBLE-ASSOCIATED PROTEIN; TMAP, LB1
Human CKAP2 gene, the cDNA of which is known as LB1, is a [[cytoskeleton]]-associated protein involved in [[mitotic]] progression. Its high transcriptional activity has been observed in the testes, thymus, and diffuse B-cell [[lymphomas]]. The gene codes for a protein of 683 residues, which lacks a [[homology modeling|homology]] to known amino acid sequences. On evidence of [[immunofluorescence]] analysis, the CKAP2 product is a [[cytoplasmic]] protein associated with cytoskeletal fibrils.
The CKAP2 gene is in [[chromosome 13]]q14. Rearrangements of this region result in various tumors. Thus deletions have been detected in multiple [[myeloma]], prostate cancer, head-and-neck squamous-cell [[carcinoma]], B-cell [[prolymphocytic leukemia]], [[non-Hodgkin lymphoma]], and in more than half cases of B-cell chronic [[lymphocytic leukemia]].


==External links==
==External links==

Latest revision as of 11:33, 9 January 2019

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.[1][2]

Human CKAP2 gene, the cDNA of which is known as LB1, is a cytoskeleton-associated protein involved in mitotic progression. Its high transcriptional activity has been observed in the testes, thymus, and diffuse B-cell lymphomas. The gene codes for a protein of 683 residues, which lacks a homology to known amino acid sequences. On evidence of immunofluorescence analysis, the CKAP2 product is a cytoplasmic protein associated with cytoskeletal fibrils. The CKAP2 gene is in chromosome 13q14. Rearrangements of this region result in various tumors. Thus deletions have been detected in multiple myeloma, prostate cancer, head-and-neck squamous-cell carcinoma, B-cell prolymphocytic leukemia, non-Hodgkin lymphoma, and in more than half cases of B-cell chronic lymphocytic leukemia.


References

  1. ↑ Maouche-Chretien L, Deleu N, Badoual C, Fraissignes P, Berger R, Gaulard P, Romeo PH, Leroy-Viard K (Oct 1998). "Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas". Oncogene. 17 (10): 1245–51. doi:10.1038/sj.onc.1202048. PMID 9771967.
  2. ↑ "Entrez Gene: CKAP2 cytoskeleton associated protein 2".

Alternative titles: TUMOR- AND MICROTUBLE-ASSOCIATED PROTEIN; TMAP, LB1

External links

Further reading



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