COG3: Difference between revisions

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{{Infobox_gene}}
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'''Conserved oligomeric Golgi complex subunit 3''' is a [[protein]] that in humans is encoded by the ''COG3'' [[gene]].<ref name="pmid11980916">{{cite journal | vauthors = Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG | title = Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function | journal = J Cell Biol | volume = 157 | issue = 3 | pages = 405–15 |date=Apr 2002 | pmid = 11980916 | pmc = 2173297 | doi = 10.1083/jcb.200202016 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COG3 component of oligomeric golgi complex 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83548| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Component of oligomeric golgi complex 3
| HGNCid = 18619
| Symbol = COG3
| AltSymbols =; SEC34
| OMIM = 606975
| ECnumber = 
| Homologene = 5854
| MGIid = 2450151
| GeneAtlas_image1 = PBB_GE_COG3_gnf1h00476_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005801 |text = cis-Golgi network}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83548
    | Hs_Ensembl = ENSG00000136152
    | Hs_RefseqProtein = NP_113619
    | Hs_RefseqmRNA = NM_031431
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 44937072
    | Hs_GenLoc_end = 45008766
    | Hs_Uniprot = Q96JB2
    | Mm_EntrezGene = 338337
    | Mm_Ensembl = ENSMUSG00000034893
    | Mm_RefseqmRNA = NM_177381
    | Mm_RefseqProtein = NP_796355
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 74436519
    | Mm_GenLoc_end = 74488579
    | Mm_Uniprot = Q3USH9
  }}
}}
'''Component of oligomeric golgi complex 3''', also known as '''COG3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COG3 component of oligomeric golgi complex 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83548| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.<ref name="entrez">{{cite web | title = Entrez Gene: COG3 component of oligomeric golgi complex 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83548| accessdate = }}</ref>
| summary_text = The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.<ref name="entrez" />
}}
}}
==Interactions==
COG3 has been shown to [[Protein-protein interaction|interact]] with [[COG2]]<ref name=pmid11929878>{{cite journal |last=Loh |first=Eva |author2=Hong Wanjin |date=Jun 2002 |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp |journal=J. Biol. Chem. |volume=277 |issue=24 |pages=21955–61 | issn = 0021-9258| pmid = 11929878 |doi = 10.1074/jbc.M202326200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[COG1]].<ref name=pmid11929878/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|COG3}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Kim DW, Sacher M, Scarpa A, ''et al.'' |title=High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking. |journal=Mol. Biol. Cell |volume=10 |issue= 10 |pages= 3317-29 |year= 1999 |pmid= 10512869 |doi=  }}
*{{cite journal  | vauthors=Kim DW, Sacher M, Scarpa A |title=High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking |journal=Mol. Biol. Cell |volume=10 |issue= 10 |pages= 3317–29 |year= 1999 |pmid= 10512869 |doi=  10.1091/mbc.10.10.3317| pmc=25597  |display-authors=etal}}
*{{cite journal  | author=VanRheenen SM, Cao X, Sapperstein SK, ''et al.'' |title=Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p. |journal=J. Cell Biol. |volume=147 |issue= 4 |pages= 729-42 |year= 1999 |pmid= 10562277 |doi=  }}
*{{cite journal  | vauthors=VanRheenen SM, Cao X, Sapperstein SK |title=Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p |journal=J. Cell Biol. |volume=147 |issue= 4 |pages= 729–42 |year= 1999 |pmid= 10562277 |doi=10.1083/jcb.147.4.729 | pmc=2156162  |display-authors=etal}}
*{{cite journal  | author=Suvorova ES, Kurten RC, Lupashin VV |title=Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22810-8 |year= 2001 |pmid= 11292827 |doi= 10.1074/jbc.M011624200 }}
*{{cite journal  | vauthors=Suvorova ES, Kurten RC, Lupashin VV |title=Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22810–8 |year= 2001 |pmid= 11292827 |doi= 10.1074/jbc.M011624200 }}
*{{cite journal  | author=Loh E, Hong W |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21955-61 |year= 2002 |pmid= 11929878 |doi= 10.1074/jbc.M202326200 }}
*{{cite journal  | vauthors=Loh E, Hong W |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21955–61 |year= 2002 |pmid= 11929878 |doi= 10.1074/jbc.M202326200 }}
*{{cite journal  | author=Ungar D, Oka T, Brittle EE, ''et al.'' |title=Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. |journal=J. Cell Biol. |volume=157 |issue= 3 |pages= 405-15 |year= 2002 |pmid= 11980916 |doi= 10.1083/jcb.200202016 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Loh E, Hong W |title=The binary interacting network of the conserved oligomeric Golgi tethering complex |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24640–8 |year= 2004 |pmid= 15047703 |doi= 10.1074/jbc.M400662200 }}
*{{cite journal  | author=Loh E, Hong W |title=The binary interacting network of the conserved oligomeric Golgi tethering complex. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24640-8 |year= 2004 |pmid= 15047703 |doi= 10.1074/jbc.M400662200 }}
*{{cite journal  | vauthors=Dunham A, Matthews LH, Burton J |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |display-authors=etal|bibcode=2004Natur.428..522D }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Latest revision as of 11:33, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.[1][2]

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.[2]

Interactions

COG3 has been shown to interact with COG2[3] and COG1.[3]

References

  1. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  2. 2.0 2.1 "Entrez Gene: COG3 component of oligomeric golgi complex 3".
  3. 3.0 3.1 Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.

External links

Further reading