PCDH17: Difference between revisions
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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.<ref name="entrez" /> PCDH17 promoter methylation is found to be closely associated with [[bladder cancer]] malignancy <ref name=" pmid = 24567353 ">{{cite journal | author = Wang XB | title = Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma. | journal = J Int Med Res. | volume = 42 | issue = |date=Apr 2014 | pmid = 24567353 | url = http://imr.sagepub.com/content/42/2/292.long | pages = 292–9 | doi=10.1177/0300060513504364}}</ref> | | summary_text = This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.<ref name="entrez" /> PCDH17 promoter methylation is found to be closely associated with [[bladder cancer]] malignancy <ref name=" pmid = 24567353 ">{{cite journal | author = Wang XB | title = Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma. | journal = J Int Med Res. | volume = 42 | issue = 2|date=Apr 2014 | pmid = 24567353 | url = http://imr.sagepub.com/content/42/2/292.long | pages = 292–9 | doi=10.1177/0300060513504364}}</ref> | ||
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{{PBB_Further_reading | {{PBB_Further_reading | ||
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*{{cite journal |vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169}} | *{{cite journal |vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169|doi-broken-date=2018-11-07 }} | ||
*{{cite journal | author=Suzuki ST |title=Recent progress in protocadherin research |journal=Exp. Cell Res. |volume=261 |issue= 1 |pages= 13–8 |year= 2000 |pmid= 11082270 |doi= 10.1006/excr.2000.5039 }} | *{{cite journal | author=Suzuki ST |title=Recent progress in protocadherin research |journal=Exp. Cell Res. |volume=261 |issue= 1 |pages= 13–8 |year= 2000 |pmid= 11082270 |doi= 10.1006/excr.2000.5039 }} | ||
*{{cite journal |vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 }} | *{{cite journal |vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 }} | ||
Latest revision as of 11:35, 9 January 2019
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Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.[1][2]
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.[2] PCDH17 promoter methylation is found to be closely associated with bladder cancer malignancy [3]
References
- ↑ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- ↑ 2.0 2.1 "Entrez Gene: PCDH17 protocadherin 17".
- ↑ Wang XB (Apr 2014). "Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma". J Int Med Res. 42 (2): 292–9. doi:10.1177/0300060513504364. PMID 24567353.
Further reading
- Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169 (inactive 2018-11-07). PMID 10817752.
- Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
- Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
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