CLDN5: Difference between revisions

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m Further reading: task, replaced: journal = J Proteome Res. → journal = J Proteome Res using AWB
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* {{cite journal | vauthors = Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E | title = Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells | journal = J. Cell Biol. | volume = 159 | issue = 2 | pages = 361–72 | year = 2002 | pmid = 12403818 | pmc = 2173042 | doi = 10.1083/jcb.200207050 }}
* {{cite journal | vauthors = Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E | title = Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells | journal = J. Cell Biol. | volume = 159 | issue = 2 | pages = 361–72 | year = 2002 | pmid = 12403818 | pmc = 2173042 | doi = 10.1083/jcb.200207050 }}
* {{cite journal | vauthors = Helms HC, Waagepetersen HS, Nielsen CU, Brodin B | title = Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth | journal = AAPS J | volume = 12 | issue = 4 | pages = 759–70 | year = 2010 | pmid = 20967520 | pmc = 2976989 | doi = 10.1208/s12248-010-9237-6 }}
* {{cite journal | vauthors = Helms HC, Waagepetersen HS, Nielsen CU, Brodin B | title = Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth | journal = AAPS J | volume = 12 | issue = 4 | pages = 759–70 | year = 2010 | pmid = 20967520 | pmc = 2976989 | doi = 10.1208/s12248-010-9237-6 }}
* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 }}
* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 }}
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Latest revision as of 12:23, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene.[1][2][3] It belongs to the group of claudins.

Function

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.[3]

Interactions

CLDN5 has been shown to interact with CLDN1[4] and CLDN3.[4]

References

  1. Peacock RE, Keen TJ, Inglehearn CF (December 1997). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
  2. Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR, Skoultchi A, Weissman SM, Kucherlapati R (Sep 1997). "Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome". Genomics. 42 (2): 245–51. doi:10.1006/geno.1997.4734. PMID 9192844.
  3. 3.0 3.1 "Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)".
  4. 4.0 4.1 Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166–78. doi:10.1152/ajplung.00182.2003. PMID 12909588.

External links

Further reading