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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Claudin-5''' is a [[protein]] that in humans is encoded by the ''CLDN5'' [[gene]].<ref name="pmid9441748">{{cite journal | vauthors = Peacock RE, Keen TJ, Inglehearn CF | title = Analysis of a human gene homologous to rat ventral prostate.1 protein | journal = Genomics | volume = 46 | issue = 3 | pages = 443–9 | date = December 1997 | pmid = 9441748 | pmc =  | doi = 10.1006/geno.1997.5033 }}</ref><ref name="pmid9192844">{{cite journal | vauthors = Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR, Skoultchi A, Weissman SM, Kucherlapati R | title = Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome | journal = Genomics | volume = 42 | issue = 2 | pages = 245–51  | date = Sep 1997 | pmid = 9192844 | pmc =  | doi = 10.1006/geno.1997.4734 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7122| accessdate = }}</ref> It belongs to the group of [[claudin]]s.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
| HGNCid = 2047
| Symbol = CLDN5
| AltSymbols =; AWAL; BEC1; CPETRL1; TMVCF
| OMIM = 602101
| ECnumber = 
| Homologene = 2459
| MGIid = 1276112
| GeneAtlas_image1 = PBB_GE_CLDN5_204482_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0016338 |text = calcium-independent cell-cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7122
    | Hs_Ensembl = ENSG00000184113
    | Hs_RefseqProtein = NP_003268
    | Hs_RefseqmRNA = NM_003277
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 17890550
    | Hs_GenLoc_end = 17895068
    | Hs_Uniprot = O00501
    | Mm_EntrezGene = 12741
    | Mm_Ensembl = ENSMUSG00000041378
    | Mm_RefseqmRNA = NM_013805
    | Mm_RefseqProtein = NP_038833
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 18690410
    | Mm_GenLoc_end = 18691823
    | Mm_Uniprot = O54942
  }}
}}
'''Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)''', also known as '''CLDN5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7122| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.<ref name="entrez">{{cite web | title = Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7122| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CLDN5 has been shown to [[Protein-protein interaction|interact]] with [[CLDN1]]<ref name=pmid12909588>{{cite journal | vauthors = Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG | title = Role of claudin interactions in airway tight junctional permeability | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 285 | issue = 5 | pages = L1166-78  | date = Nov 2003 | pmid = 12909588 | doi = 10.1152/ajplung.00182.2003 }}</ref> and [[CLDN3]].<ref name=pmid12909588/>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CLDN5}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kniesel U, Wolburg H | title = Tight junctions of the blood-brain barrier | journal = Cell. Mol. Neurobiol. | volume = 20 | issue = 1 | pages = 57–76 | year = 2000 | pmid = 10690502 | doi = 10.1023/A:1006995910836 }}
| citations =
* {{cite journal | vauthors = Heiskala M, Peterson PA, Yang Y | title = The roles of claudin superfamily proteins in paracellular transport | journal = Traffic | volume = 2 | issue = 2 | pages = 93–8 | year = 2001 | pmid = 11247307 | doi = 10.1034/j.1600-0854.2001.020203.x }}
*{{cite journal | author=Kniesel U, Wolburg H |title=Tight junctions of the blood-brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57-76 |year= 2000 |pmid= 10690502 |doi= }}
* {{cite journal | vauthors = Tsukita S, Furuse M, Itoh M | title = Multifunctional strands in tight junctions | journal = Nat. Rev. Mol. Cell Biol. | volume = 2 | issue = 4 | pages = 285–93 | year = 2001 | pmid = 11283726 | doi = 10.1038/35067088 }}
*{{cite journal | author=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93-8 |year= 2001 |pmid= 11247307 |doi= }}
* {{cite journal | vauthors = Tsukita S, Furuse M | title = Claudin-based barrier in simple and stratified cellular sheets | journal = Curr. Opin. Cell Biol. | volume = 14 | issue = 5 | pages = 531–6 | year = 2002 | pmid = 12231346 | doi = 10.1016/S0955-0674(02)00362-9 }}
*{{cite journal | author=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285-93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
* {{cite journal | vauthors = González-Mariscal L, Betanzos A, Nava P, Jaramillo BE | title = Tight junction proteins | journal = Prog. Biophys. Mol. Biol. | volume = 81 | issue = 1 | pages = 1–44 | year = 2003 | pmid = 12475568 | doi = 10.1016/S0079-6107(02)00037-8 }}
*{{cite journal | author=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531-6 |year= 2003 |pmid= 12231346 |doi= }}
* {{cite journal | vauthors = King JE, Eugenin EA, Buckner CM, Berman JW | title = HIV tat and neurotoxicity | journal = Microbes Infect. | volume = 8 | issue = 5 | pages = 1347–57 | year = 2006 | pmid = 16697675 | doi = 10.1016/j.micinf.2005.11.014 }}
*{{cite journal | author=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1-44 |year= 2003 |pmid= 12475568 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=King JE, Eugenin EA, Buckner CM, Berman JW |title=HIV tat and neurotoxicity. |journal=Microbes Infect. |volume=8 |issue= 5 |pages= 1347-57 |year= 2006 |pmid= 16697675 |doi= 10.1016/j.micinf.2005.11.014 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Morita K, Furuse M, Fujimoto K, Tsukita S | title = Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 2 | pages = 511–6 | year = 1999 | pmid = 9892664 | pmc = 15167 | doi = 10.1073/pnas.96.2.511 }}
*{{cite journal  | author=Sirotkin H, Morrow B, Saint-Jore B, ''et al.'' |title=Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. |journal=Genomics |volume=42 |issue= 2 |pages= 245-51 |year= 1997 |pmid= 9192844 |doi=  }}
* {{cite journal | vauthors = Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S | title = Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1351–63 | year = 1999 | pmid = 10601346 | pmc = 2168087 | doi = 10.1083/jcb.147.6.1351 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
* {{cite journal | vauthors = Kojima S, Rahner C, Peng S, Rizzolo LJ | title = Claudin 5 is transiently expressed during the development of the retinal pigment epithelium | journal = J. Membr. Biol. | volume = 186 | issue = 2 | pages = 81–8 | year = 2002 | pmid = 11944085 | doi = 10.1007/s00232-001-0137-7 }}
*{{cite journal  | author=Peacock RE, Keen TJ, Inglehearn CF |title=Analysis of a human gene homologous to rat ventral prostate.1 protein. |journal=Genomics |volume=46 |issue= 3 |pages= 443-9 |year= 1998 |pmid= 9441748 |doi= 10.1006/geno.1997.5033 }}
* {{cite journal | vauthors = Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E | title = Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells | journal = J. Cell Biol. | volume = 159 | issue = 2 | pages = 361–72 | year = 2002 | pmid = 12403818 | pmc = 2173042 | doi = 10.1083/jcb.200207050 }}
*{{cite journal | author=Morita K, Furuse M, Fujimoto K, Tsukita S |title=Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 511-6 |year= 1999 |pmid= 9892664 |doi= }}
* {{cite journal | vauthors = Helms HC, Waagepetersen HS, Nielsen CU, Brodin B | title = Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth | journal = AAPS J | volume = 12 | issue = 4 | pages = 759–70 | year = 2010 | pmid = 20967520 | pmc = 2976989 | doi = 10.1208/s12248-010-9237-6 }}
*{{cite journal | author=Itoh M, Furuse M, Morita K, ''et al.'' |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351-63 |year= 2000 |pmid= 10601346 |doi= }}
* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 }}
*{{cite journal | author=Kojima S, Rahner C, Peng S, Rizzolo LJ |title=Claudin 5 is transiently expressed during the development of the retinal pigment epithelium. |journal=J. Membr. Biol. |volume=186 |issue= 2 |pages= 81-8 |year= 2002 |pmid= 11944085 |doi= 10.1007/s00232-001-0137-7 }}
*{{cite journal | author=Poliak S, Matlis S, Ullmer C, ''et al.'' |title=Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. |journal=J. Cell Biol. |volume=159 |issue= 2 |pages= 361-72 |year= 2002 |pmid= 12403818 |doi= 10.1083/jcb.200207050 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 12:23, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene.[1][2][3] It belongs to the group of claudins.

Function

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.[3]

Interactions

CLDN5 has been shown to interact with CLDN1[4] and CLDN3.[4]

References

  1. ↑ Peacock RE, Keen TJ, Inglehearn CF (December 1997). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
  2. ↑ Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR, Skoultchi A, Weissman SM, Kucherlapati R (Sep 1997). "Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome". Genomics. 42 (2): 245–51. doi:10.1006/geno.1997.4734. PMID 9192844.
  3. ↑ 3.0 3.1 "Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)".
  4. ↑ 4.0 4.1 Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166–78. doi:10.1152/ajplung.00182.2003. PMID 12909588.

External links

Further reading


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