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{{Infobox_gene}}
{{PBB_Controls
'''Ran-specific binding protein 1''' is an [[enzyme]] that in humans is encoded by the ''RANBP1'' [[gene]].<ref name="pmid7616957">{{cite journal |vauthors=Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T | title = RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4 | journal = Mol Gen Genet | volume = 247 | issue = 6 | pages = 661–9 |date=August 1995 | pmid = 7616957 | pmc =  | doi =10.1007/BF00290397 }}</ref><ref name="pmid10330396">{{cite journal |vauthors=Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L | title = A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export | journal = J Cell Biol | volume = 145 | issue = 4 | pages = 645–57 |date=July 1999 | pmid = 10330396 | pmc = 2133185 | doi =10.1083/jcb.145.4.645 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RANBP1 RAN binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5902| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RANBP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k5d.
| PDB = {{PDB2|1k5d}}, {{PDB2|1k5g}}
| Name = RAN binding protein 1
| HGNCid = 9847
| Symbol = RANBP1
| AltSymbols =; MGC88701
| OMIM = 601180
| ECnumber =
| Homologene = 21600
| MGIid = 96269
  | Function = {{GNF_GO|id=GO:0005092 |text = GDP-dissociation inhibitor activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0008536 |text = Ran GTPase binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0007051 |text = spindle organization and biogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0046604 |text = positive regulation of mitotic centrosome separation}} {{GNF_GO|id=GO:0046907 |text = intracellular transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5902
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_002873
    | Hs_RefseqmRNA = NM_002882
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr =   
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 19385
    | Mm_Ensembl = ENSMUSG00000005732
    | Mm_RefseqmRNA = NM_011239
    | Mm_RefseqProtein = NP_035369
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 18153650
    | Mm_GenLoc_end = 18161000
    | Mm_Uniprot = O08846
  }}
}}
'''RAN binding protein 1''', also known as '''RANBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RANBP1 RAN binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5902| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.<ref name="entrez">{{cite web | title = Entrez Gene: RANBP1 RAN binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5902| accessdate = }}</ref>
| summary_text = Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.<ref name="entrez" />
}}
}}
==Interactions==
RANBP1 has been shown to [[Protein-protein interaction|interact]] with [[XPO1]],<ref name=pmid10601307>{{cite journal |last=Singh |first=B B |authorlink= |author2=Patel H H |author3=Roepman R |author4=Schick D |author5=Ferreira P A  |date=December 1999  |title=The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1 |journal=J. Biol. Chem. |volume=274 |issue=52 |pages=37370–8 |publisher= |location = United States| issn = 0021-9258| pmid = 10601307 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.52.37370 }}</ref><ref name=pmid10779340>{{cite journal |last=Plafker |first=K |authorlink= |author2=Macara I G  |date=May 2000 |title=Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1 |journal=Mol. Cell. Biol. |volume=20 |issue=10 |pages=3510–21 |publisher= |location = United States| issn = 0270-7306| pmid = 10779340 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.20.10.3510-3521.2000 |pmc=85643 }}</ref> [[KPNB1]]<ref name=pmid10779340/><ref name=pmid10473610>{{cite journal |last=Yaseen |first=N R |authorlink= |author2=Blobel G  |date=September 1999  |title=GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358 |journal=J. Biol. Chem. |volume=274 |issue=37 |pages=26493–502 |publisher= |location = United States| issn = 0021-9258| pmid = 10473610 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.37.26493 }}</ref> and [[Ran (biology)|Ran]].<ref name=pmid10779340/><ref name=pmid7891706>{{cite journal |last=Ren |first=M |authorlink= |author2=Villamarin A |author3=Shih A |author4=Coutavas E |author5=Moore M S |author6=LoCurcio M |author7=Clarke V |author8=Oppenheim J D |author9=D'Eustachio P |author10=Rush M G  |date=April 1995  |title=Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing |journal=Mol. Cell. Biol. |volume=15 |issue=4 |pages=2117–24 |publisher= |location = United States| issn = 0270-7306| pmid = 7891706 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=230439 }}</ref><ref name=pmid10811801>{{cite journal |last=Steggerda |first=S M |authorlink= |author2=Paschal B M  |date=July 2000  |title=The mammalian Mog1 protein is a guanine nucleotide release factor for Ran |journal=J. Biol. Chem. |volume=275 |issue=30 |pages=23175–80 |publisher= |location = United States| issn = 0021-9258| pmid = 10811801 |doi = 10.1074/jbc.C000252200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Hayashi N, Yokoyama N, Seki T, ''et al.'' |title=RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. |journal=Mol. Gen. Genet. |volume=247 |issue= 6 |pages= 661-9 |year= 1995 |pmid= 7616957 |doi=  }}
*{{cite journal  | author=Bischoff FR |title=Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1 |journal=EMBO J. |volume=14 |issue= 4 |pages= 705–15 |year= 1995 |pmid= 7882974 |doi=  | pmc=398135 |name-list-format=vanc| author2=Krebber H | author3=Smirnova E | display-authors=3  | last4=Dong  | first4=W  | last5=Ponstingl  | first5=H }}
*{{cite journal | author=Bischoff FR, Krebber H, Smirnova E, ''et al.'' |title=Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. |journal=EMBO J. |volume=14 |issue= 4 |pages= 705-15 |year= 1995 |pmid= 7882974 |doi=  }}
*{{cite journal  | author=Ren M |title=Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing |journal=Mol. Cell. Biol. |volume=15 |issue= 4 |pages= 2117–24 |year= 1995 |pmid= 7891706 |doi=  | pmc=230439 |name-list-format=vanc| author2=Villamarin A  | author3=Shih A  | display-authors=3  | last4=Coutavas  | first4=E  | last5=Moore  | first5=MS  | last6=Locurcio  | first6=M  | last7=Clarke  | first7=V  | last8=Oppenheim  | first8=JD  | last9=d'Eustachio  | first9=P }}
*{{cite journal  | author=Ren M, Villamarin A, Shih A, ''et al.'' |title=Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. |journal=Mol. Cell. Biol. |volume=15 |issue= 4 |pages= 2117-24 |year= 1995 |pmid= 7891706 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Coutavas E |title=Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4 |journal=Nature |volume=366 |issue= 6455 |pages= 585–7 |year= 1994 |pmid= 8255297 |doi= 10.1038/366585a0 |name-list-format=vanc| author2=Ren M  | author3=Oppenheim JD  | display-authors=3  | last4=d'Eustachio  | first4=Peter  | last5=Rush  | first5=Mark G. |bibcode=1993Natur.366..585C}}
*{{cite journal  | author=Coutavas E, Ren M, Oppenheim JD, ''et al.'' |title=Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. |journal=Nature |volume=366 |issue= 6455 |pages= 585-7 |year= 1994 |pmid= 8255297 |doi= 10.1038/366585a0 }}
*{{cite journal  |vauthors=Zolotukhin AS, Felber BK |title=Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1 |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 11356–60 |year= 1997 |pmid= 9111043 |doi=10.1074/jbc.272.17.11356  }}
*{{cite journal  | author=Zolotukhin AS, Felber BK |title=Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 11356-60 |year= 1997 |pmid= 9111043 |doi= }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=Akira  | last5=Sugano  | first5=Sumio  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Plafker K, Macara IG |title=Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1 |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3510–21 |year= 2000 |pmid= 10779340 |doi=10.1128/MCB.20.10.3510-3521.2000  | pmc=85643 }}
*{{cite journal  | author=Kehlenbach RH, Dickmanns A, Kehlenbach A, ''et al.'' |title=A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 645-57 |year= 1999 |pmid= 10330396 |doi= }}
*{{cite journal  |vauthors=Steggerda SM, Paschal BM |title=The mammalian Mog1 protein is a guanine nucleotide release factor for Ran |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23175–80 |year= 2000 |pmid= 10811801 |doi= 10.1074/jbc.C000252200 }}
*{{cite journal  | author=Plafker K, Macara IG |title=Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3510-21 |year= 2000 |pmid= 10779340 |doi= }}
*{{cite journal  | author=Maynard TM |title=RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction |journal=Mech. Dev. |volume=111 |issue= 1–2 |pages= 177–80 |year= 2002 |pmid= 11804793 |doi=10.1016/S0925-4773(01)00616-5 |name-list-format=vanc| author2=Haskell GT  | author3=Bhasin N  | display-authors=3  | last4=Lee  | first4=James M  | last5=Gassman  | first5=Andrew A  | last6=Lieberman  | first6=Jeffrey A  | last7=Lamantia  | first7=Anthony-Samuel }}
*{{cite journal | author=Steggerda SM, Paschal BM |title=The mammalian Mog1 protein is a guanine nucleotide release factor for Ran. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23175-80 |year= 2000 |pmid= 10811801 |doi= 10.1074/jbc.C000252200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | author=Maynard TM, Haskell GT, Bhasin N, ''et al.'' |title=RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction. |journal=Mech. Dev. |volume=111 |issue= 1-2 |pages= 177-80 |year= 2002 |pmid= 11804793 |doi=  }}
*{{cite journal  | author=Di Fiore B |title=Mammalian RanBP1 regulates centrosome cohesion during mitosis |journal=J. Cell Sci. |volume=116 |issue= Pt 16 |pages= 3399–411 |year= 2004 |pmid= 12840069 |doi= 10.1242/jcs.00624  |name-list-format=vanc| author2=Ciciarello M | author3=Mangiacasale R  | display-authors=3  | last4=Palena  | first4=A | last5=Tassin  | first5=AM  | last6=Cundari  | first6=E  | last7=Lavia  | first7=P }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Seewald MJ |title=Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction? |journal=Mol. Cell. Biol. |volume=23 |issue= 22 |pages= 8124–36 |year= 2003 |pmid= 14585972 |doi=10.1128/MCB.23.22.8124-8136.2003 | pmc=262373 |name-list-format=vanc| author2=Kraemer A  | author3=Farkasovsky M  | display-authors=3  | last4=Korner  | first4=C.  | last5=Wittinghofer  | first5=A. | last6=Vetter  | first6=I. R.  }}
*{{cite journal  | author=Di Fiore B, Ciciarello M, Mangiacasale R, ''et al.'' |title=Mammalian RanBP1 regulates centrosome cohesion during mitosis. |journal=J. Cell. Sci. |volume=116 |issue= Pt 16 |pages= 3399-411 |year= 2004 |pmid= 12840069 |doi= 10.1242/jcs.00624 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Seewald MJ, Kraemer A, Farkasovsky M, ''et al.'' |title=Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction? |journal=Mol. Cell. Biol. |volume=23 |issue= 22 |pages= 8124-36 |year= 2003 |pmid= 14585972 |doi=  }}
*{{cite journal  |vauthors=Bohlson SS, Zhang M, Ortiz CE, Tenner AJ |title=CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis |journal=J. Leukoc. Biol. |volume=77 |issue= 1 |pages= 80–9 |year= 2005 |pmid= 15459234 |doi= 10.1189/jlb.0504305 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84  | pmc=545604  |name-list-format=vanc| author2=Wright CL  | author3=Edwards CA  | display-authors=3  | last4=Davis  | first4=Matthew P  | last5=Grinham  | first5=James A  | last6=Cole  | first6=Charlotte G  | last7=Goward  | first7=Melanie E  | last8=Aguado  | first8=Begoña  | last9=Mallya  | first9=Meera }}
*{{cite journal | author=Bohlson SS, Zhang M, Ortiz CE, Tenner AJ |title=CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis. |journal=J. Leukoc. Biol. |volume=77 |issue= 1 |pages= 80-9 |year= 2005 |pmid= 15459234 |doi= 10.1189/jlb.0504305 }}
*{{cite journal  | author=Bruneel A |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239  |name-list-format=vanc| author2=Labas V  | author3=Mailloux A  | display-authors=3  | last4=Sharma  | first4=Sanjiv  | last5=Royer  | first5=Nicolas  | last6=Vinh  | first6=Joëlle  | last7=Pernet  | first7=Pascal  | last8=Vaubourdolle  | first8=Michel  | last9=Baudin  | first9=Bruno }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  |vauthors=Takeda E, Hieda M, Katahira J, Yoneda Y |title=Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1 |journal=Cell Struct. Funct. |volume=30 |issue= 2 |pages= 69–80 |year= 2006 |pmid= 16428860 |doi=10.1247/csf.30.69  }}
*{{cite journal | author=Bruneel A, Labas V, Mailloux A, ''et al.'' |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |journal=Proteomics |volume=5 |issue= 15 |pages= 3876-84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239 }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948  |name-list-format=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor | first9=Liam }}
*{{cite journal  | author=Takeda E, Hieda M, Katahira J, Yoneda Y |title=Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. |journal=Cell Struct. Funct. |volume=30 |issue= 2 |pages= 69-80 |year= 2006 |pmid= 16428860 |doi=  }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5902}}


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Latest revision as of 12:26, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.[1][2][3]

Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.[3]

Interactions

RANBP1 has been shown to interact with XPO1,[4][5] KPNB1[5][6] and Ran.[5][7][8]

References

  1. ↑ Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (August 1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Mol Gen Genet. 247 (6): 661–9. doi:10.1007/BF00290397. PMID 7616957.
  2. ↑ Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L (July 1999). "A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export". J Cell Biol. 145 (4): 645–57. doi:10.1083/jcb.145.4.645. PMC 2133185. PMID 10330396.
  3. ↑ 3.0 3.1 "Entrez Gene: RANBP1 RAN binding protein 1".
  4. ↑ Singh, B B; Patel H H; Roepman R; Schick D; Ferreira P A (December 1999). "The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1". J. Biol. Chem. United States. 274 (52): 37370–8. doi:10.1074/jbc.274.52.37370. ISSN 0021-9258. PMID 10601307.
  5. ↑ 5.0 5.1 5.2 Plafker, K; Macara I G (May 2000). "Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1". Mol. Cell. Biol. United States. 20 (10): 3510–21. doi:10.1128/MCB.20.10.3510-3521.2000. ISSN 0270-7306. PMC 85643. PMID 10779340.
  6. ↑ Yaseen, N R; Blobel G (September 1999). "GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358". J. Biol. Chem. United States. 274 (37): 26493–502. doi:10.1074/jbc.274.37.26493. ISSN 0021-9258. PMID 10473610.
  7. ↑ Ren, M; Villamarin A; Shih A; Coutavas E; Moore M S; LoCurcio M; Clarke V; Oppenheim J D; D'Eustachio P; Rush M G (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Mol. Cell. Biol. United States. 15 (4): 2117–24. ISSN 0270-7306. PMC 230439. PMID 7891706.
  8. ↑ Steggerda, S M; Paschal B M (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". J. Biol. Chem. United States. 275 (30): 23175–80. doi:10.1074/jbc.C000252200. ISSN 0021-9258. PMID 10811801.

Further reading


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