CDC45-related protein: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''CDC45''' is a [[protein]] that in humans is encoded by the ''CDC45L'' [[gene]].<ref name="pmid9660782">{{cite journal | vauthors = Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A | title = The human homolog of Saccharomyces cerevisiae CDC45 | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18205–9  | date = Aug 1998 | pmid = 9660782 | pmc =  | doi = 10.1074/jbc.273.29.18205 }}</ref><ref name="pmid9724329">{{cite journal | vauthors = McKie JM, Wadey RB, Sutherland HF, Taylor CL, Scambler PJ | title = Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene | journal = Genome Res. | volume = 8 | issue = 8 | pages = 834–41  | date = Sep 1998 | pmid = 9724329 | pmc = 310757 | doi = 10.1101/gr.8.8.834 }}</ref><ref name="pmid17608804">{{cite journal | vauthors = Pollok S, Bauerschmidt C, Sänger J, Nasheuer HP, Grosse F | title = Human Cdc45 is a proliferation-associated antigen | journal = FEBS J. | volume = 274 | issue = 14 | pages = 3669–84  | date = Jul 2007 | pmid = 17608804 | pmc =  | doi = 10.1111/j.1742-4658.2007.05900.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8318| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CDC45 cell division cycle 45-like (S. cerevisiae)
| HGNCid = 1739
| Symbol = CDC45L
| AltSymbols =; CDC45; CDC45L2; PORC-PI-1
| OMIM = 603465
| ECnumber = 
| Homologene = 2616
| MGIid = 1338073
| GeneAtlas_image1 = PBB_GE_CDC45L_204126_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000076 |text = DNA replication checkpoint}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006270 |text = DNA replication initiation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8318
    | Hs_Ensembl = ENSG00000093009
    | Hs_RefseqProtein = NP_003495
    | Hs_RefseqmRNA = NM_003504
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 17847416
    | Hs_GenLoc_end = 17888134
    | Hs_Uniprot = O75419
    | Mm_EntrezGene = 12544
    | Mm_Ensembl = ENSMUSG00000000028
    | Mm_RefseqmRNA = NM_009862
    | Mm_RefseqProtein = NP_033992
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 18694015
    | Mm_GenLoc_end = 18725535
    | Mm_Uniprot = Q3UI99
  }}
}}
'''CDC45 cell division cycle 45-like (S. cerevisiae)''', also known as '''CDC45L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8318| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of [[DNA replication]]. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the [[minichromosome maintenance]] proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in [[Xenopus]] suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.<ref name="entrez">{{cite web | title = Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8318| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CDC45-related protein has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
* [[MCM3]],<ref name = pmid12614612/>
{{PBB_Further_reading
* [[MCM6]],<ref name = pmid12614612/>
| citations =  
* [[MCM7]],<ref name = pmid12614612/><ref name = pmid10518787>{{cite journal | vauthors = Kukimoto I, Igaki H, Kanda T | title = Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha | journal = Eur. J. Biochem. | volume = 265 | issue = 3 | pages = 936–43  | date = Nov 1999 | pmid = 10518787 | doi =  10.1046/j.1432-1327.1999.00791.x}}</ref>
*{{cite journal | author=Leatherwood J |title=Emerging mechanisms of eukaryotic DNA replication initiation. |journal=Curr. Opin. Cell Biol. |volume=10 |issue= 6 |pages= 742-8 |year= 1999 |pmid= 9914182 |doi=  }}
* [[ORC1L]],<ref name = pmid12614612>{{cite journal | vauthors = Kneissl M, Pütter V, Szalay AA, Grummt F | title = Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells | journal = J. Mol. Biol. | volume = 327 | issue = 1 | pages = 111–28  | date = Mar 2003 | pmid = 12614612 | doi =  10.1016/s0022-2836(03)00079-2}}</ref>  and
*{{cite journal | author=Saha P, Thome KC, Yamaguchi R, ''et al.'' |title=The human homolog of Saccharomyces cerevisiae CDC45. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18205-9 |year= 1998 |pmid= 9660782 |doi=  }}
* [[ORC6L]].<ref name = pmid12614612/>
*{{cite journal | author=McKie JM, Wadey RB, Sutherland HF, ''et al.'' |title=Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. |journal=Genome Res. |volume=8 |issue= 8 |pages= 834-41 |year= 1998 |pmid= 9724329 |doi= }}
{{Clear}}
*{{cite journal | author=Mimura S, Takisawa H |title=Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. |journal=EMBO J. |volume=17 |issue= 19 |pages= 5699-707 |year= 1998 |pmid= 9755170 |doi= 10.1093/emboj/17.19.5699 }}
 
*{{cite journal | author=Shaikh TH, Gottlieb S, Sellinger B, ''et al.'' |title=Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development. |journal=Mamm. Genome |volume=10 |issue= 3 |pages= 322-6 |year= 1999 |pmid= 10051334 |doi= }}
== References ==
*{{cite journal | author=Kukimoto I, Igaki H, Kanda T |title=Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha. |journal=Eur. J. Biochem. |volume=265 |issue= 3 |pages= 936-43 |year= 1999 |pmid= 10518787 |doi= }}
{{reflist|35em}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
 
*{{cite journal | author=Kneissl M, Pütter V, Szalay AA, Grummt F |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |journal=J. Mol. Biol. |volume=327 |issue= 1 |pages= 111-28 |year= 2003 |pmid= 12614612 |doi= }}
== Further reading ==
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
{{refbegin|35em}}
*{{cite journal | author=Ramachandran N, Hainsworth E, Bhullar B, ''et al.'' |title=Self-assembling protein microarrays. |journal=Science |volume=305 |issue= 5680 |pages= 86-90 |year= 2004 |pmid= 15232106 |doi= 10.1126/science.1097639 }}
* {{cite journal | vauthors = Leatherwood J | title = Emerging mechanisms of eukaryotic DNA replication initiation | journal = Curr. Opin. Cell Biol. | volume = 10 | issue = 6 | pages = 742–8 | year = 1998 | pmid = 9914182 | doi = 10.1016/S0955-0674(98)80117-8 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Mimura S, Takisawa H | title = Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk | journal = EMBO J. | volume = 17 | issue = 19 | pages = 5699–707 | year = 1998 | pmid = 9755170 | pmc = 1170898 | doi = 10.1093/emboj/17.19.5699 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Shaikh TH, Gottlieb S, Sellinger B, Chen F, Roe BA, Oakey RJ, Emanuel BS, Budarf ML | title = Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development | journal = Mamm. Genome | volume = 10 | issue = 3 | pages = 322–6 | year = 1999 | pmid = 10051334 | doi = 10.1007/s003359900996 }}
*{{cite journal | author=Liu P, Barkley LR, Day T, ''et al.'' |title=The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30631-44 |year= 2006 |pmid= 16912045 |doi= 10.1074/jbc.M602982200 }}
* {{cite journal | vauthors = Kukimoto I, Igaki H, Kanda T | title = Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha | journal = Eur. J. Biochem. | volume = 265 | issue = 3 | pages = 936–43 | year = 1999 | pmid = 10518787 | doi = 10.1046/j.1432-1327.1999.00791.x }}
*{{cite journal | author=Masai H, Taniyama C, Ogino K, ''et al.'' |title=Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39249-61 |year= 2007 |pmid= 17046832 |doi= 10.1074/jbc.M608935200 }}
* {{cite journal | vauthors = Kneissl M, Pütter V, Szalay AA, Grummt F | title = Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells | journal = J. Mol. Biol. | volume = 327 | issue = 1 | pages = 111–28 | year = 2003 | pmid = 12614612 | doi = 10.1016/S0022-2836(03)00079-2 }}
*{{cite journal | author=Boskovic J, Coloma J, Aparicio T, ''et al.'' |title=Molecular architecture of the human GINS complex. |journal=EMBO Rep. |volume=8 |issue= 7 |pages= 678-84 |year= 2007 |pmid= 17557111 |doi= 10.1038/sj.embor.7401002 }}
* {{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Res. | volume = 13 | issue = 10 | pages = 2265–70 | year = 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }}
*{{cite journal | author=Bauerschmidt C, Pollok S, Kremmer E, ''et al.'' |title=Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. |journal=Genes Cells |volume=12 |issue= 6 |pages= 745-58 |year= 2007 |pmid= 17573775 |doi= 10.1111/j.1365-2443.2007.01090.x }}
* {{cite journal | vauthors = Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J | title = Self-assembling protein microarrays | journal = Science | volume = 305 | issue = 5680 | pages = 86–90 | year = 2004 | pmid = 15232106 | doi = 10.1126/science.1097639 }}
*{{cite journal | author=Pollok S, Bauerschmidt C, Sänger J, ''et al.'' |title=Human Cdc45 is a proliferation-associated antigen. |journal=FEBS J. |volume=274 |issue= 14 |pages= 3669-84 |year= 2007 |pmid= 17608804 |doi= 10.1111/j.1742-4658.2007.05900.x }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Pollok S, Grosse F |title=Cdc45 degradation during differentiation and apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=362 |issue= 4 |pages= 910-5 |year= 2007 |pmid= 17767920 |doi= 10.1016/j.bbrc.2007.08.069 }}
* {{cite journal | vauthors = Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheuer HP, Vaziri C | title = The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism | journal = J. Biol. Chem. | volume = 281 | issue = 41 | pages = 30631–44 | year = 2006 | pmid = 16912045 | doi = 10.1074/jbc.M602982200 }}
}}
* {{cite journal | vauthors = Masai H, Taniyama C, Ogino K, Matsui E, Kakusho N, Matsumoto S, Kim JM, Ishii A, Tanaka T, Kobayashi T, Tamai K, Ohtani K, Arai K | title = Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin | journal = J. Biol. Chem. | volume = 281 | issue = 51 | pages = 39249–61 | year = 2006 | pmid = 17046832 | doi = 10.1074/jbc.M608935200 }}
* {{cite journal | vauthors = Boskovic J, Coloma J, Aparicio T, Zhou M, Robinson CV, Méndez J, Montoya G | title = Molecular architecture of the human GINS complex | journal = EMBO Rep. | volume = 8 | issue = 7 | pages = 678–84 | year = 2007 | pmid = 17557111 | pmc = 1905900 | doi = 10.1038/sj.embor.7401002 }}
* {{cite journal | vauthors = Bauerschmidt C, Pollok S, Kremmer E, Nasheuer HP, Grosse F | title = Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase | journal = Genes Cells | volume = 12 | issue = 6 | pages = 745–58 | year = 2007 | pmid = 17573775 | doi = 10.1111/j.1365-2443.2007.01090.x }}
* {{cite journal | vauthors = Pollok S, Grosse F | title = Cdc45 degradation during differentiation and apoptosis | journal = Biochem. Biophys. Res. Commun. | volume = 362 | issue = 4 | pages = 910–5 | year = 2007 | pmid = 17767920 | doi = 10.1016/j.bbrc.2007.08.069 }}
{{refend}}
{{refend}}
==External links==
* {{UCSC gene info|CDC45}}


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Latest revision as of 12:26, 9 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CDC45 is a protein that in humans is encoded by the CDC45L gene.[1][2][3][4]

Function

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.[4]

Interactions

CDC45-related protein has been shown to interact with:

References

  1. ↑ Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A (Aug 1998). "The human homolog of Saccharomyces cerevisiae CDC45". J. Biol. Chem. 273 (29): 18205–9. doi:10.1074/jbc.273.29.18205. PMID 9660782.
  2. ↑ McKie JM, Wadey RB, Sutherland HF, Taylor CL, Scambler PJ (Sep 1998). "Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene". Genome Res. 8 (8): 834–41. doi:10.1101/gr.8.8.834. PMC 310757. PMID 9724329.
  3. ↑ Pollok S, Bauerschmidt C, Sänger J, Nasheuer HP, Grosse F (Jul 2007). "Human Cdc45 is a proliferation-associated antigen". FEBS J. 274 (14): 3669–84. doi:10.1111/j.1742-4658.2007.05900.x. PMID 17608804.
  4. ↑ 4.0 4.1 "Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)".
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
  6. ↑ Kukimoto I, Igaki H, Kanda T (Nov 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. 265 (3): 936–43. doi:10.1046/j.1432-1327.1999.00791.x. PMID 10518787.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=CDC45-related_protein&oldid=1518865"