PDE8A: Difference between revisions

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'''High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A''' is an [[enzyme]] that in humans is encoded by the ''PDE8A'' [[gene]].<ref name="pmid9618252">{{cite journal | vauthors = Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB | title = Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase | journal = Biochem Biophys Res Commun | volume = 246 | issue = 3 | pages = 570–7 |date=Jul 1998 | pmid = 9618252 | pmc =  | doi = 10.1006/bbrc.1998.8684 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE8A phosphodiesterase 8A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5151| accessdate = }}</ref> Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.<ref name="pmid21920574">{{cite journal | vauthors = Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, ((Strauss JF III)), Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB | title = Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages | journal = Virology |date=Sep 2011 | pmid = 21920574 | doi=10.1016/j.virol.2011.08.013 | volume=420 | issue=1 | pages=32–42}}</ref>
'''High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A''' is an [[enzyme]] that in humans is encoded by the ''PDE8A'' [[gene]].<ref name="pmid9618252">{{cite journal | vauthors = Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB | title = Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase | journal = Biochem Biophys Res Commun | volume = 246 | issue = 3 | pages = 570–7 |date=Jul 1998 | pmid = 9618252 | pmc =  | doi = 10.1006/bbrc.1998.8684 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE8A phosphodiesterase 8A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5151| accessdate = }}</ref> Work by Sebastiaan Bol et al. showed that 5 different [[transcript variants]] and their corresponding [[isoforms]] are [[Gene expression|expressed]] in human [[Macrophage|macrophages]], and suggests that this protein may be required by [[HIV|HIV-1]] for its [[Viral replication|replication]].<ref name="pmid21920574">{{cite journal | vauthors = Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, ((Strauss JF III)), Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB | title = Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages | journal = Virology |date=Sep 2011 | pmid = 21920574 | doi=10.1016/j.virol.2011.08.013 | volume=420 | issue=1 | pages=32–42}}</ref>


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Latest revision as of 12:47, 9 January 2019

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.[1][2] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.[3]


References

  1. ↑ Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–7. doi:10.1006/bbrc.1998.8684. PMID 9618252.
  2. ↑ "Entrez Gene: PDE8A phosphodiesterase 8A".
  3. ↑ Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF III, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology. 420 (1): 32–42. doi:10.1016/j.virol.2011.08.013. PMID 21920574.

Further reading



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