MDGA2: Difference between revisions
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| publisher = [[Weizmann Institute of Science]] | | publisher = [[Weizmann Institute of Science]] | ||
| date = 2008-09-08 | | date = 2008-09-08 | ||
| url = | | url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=MDGA2 | ||
}}</ref> | }}</ref> | ||
''MDGA2'' is located on [[chromosome 14]]. | ''MDGA2'' is located on [[chromosome 14]]. | ||
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| url = http://archpsyc.ama-assn.org/cgi/content/full/65/9/1062 | | url = http://archpsyc.ama-assn.org/cgi/content/full/65/9/1062 | ||
| doi = 10.1001/archpsyc.65.9.1062 | | doi = 10.1001/archpsyc.65.9.1062 | ||
}}</ref> However, a more recent study has failed to replicate that finding<ref>{{Cite journal|last=Hettema|first=John M.|last2=Oord|first2=Edwin J.C.G. van den|last3=An|first3=Seon-Sook|last4=Kendler|first4=Kenneth S.|last5=Chen|first5=Xiangning|title=Follow-up association study of novel neuroticism gene MAMDC1|url=http://content.wkhealth.com/linkback/openurl? | }}</ref> However, a more recent study has failed to replicate that finding.<ref>{{Cite journal|last=Hettema|first=John M.|last2=Oord|first2=Edwin J.C.G. van den|last3=An|first3=Seon-Sook|last4=Kendler|first4=Kenneth S.|last5=Chen|first5=Xiangning|title=Follow-up association study of novel neuroticism gene MAMDC1|url=http://content.wkhealth.com/linkback/openurl?&an=00041444-200908000-00009|journal=Psychiatric Genetics|volume=19|issue=4|pages=213–214|doi=10.1097/ypg.0b013e32832cec22|pmc=2844892}}</ref> | ||
== References == | == References == | ||
Latest revision as of 06:17, 10 January 2019
| MAM domain containing glycosylphosphatidylinositol anchor 2 | |
|---|---|
| Identifiers | |
| Symbol | MDGA2 |
| Alt. symbols | MAMDC1 |
| Entrez | 161357 |
| HUGO | 19835 |
| OMIM | 611128 |
| RefSeq | NM_182830 |
| Other data | |
| Locus | Chr. 14 q21.2 |
MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.
The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]
There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5] However, a more recent study has failed to replicate that finding.[6]
References
- ↑ "MDGA2 Gene — GeneCards". Weizmann Institute of Science. 2008-09-08.
- ↑ "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. Retrieved 2008-11-14.
- ↑ Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD (February 2004). "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neuroscience. 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID 15019943.
- ↑ "SNP linked to Gene MDGA2". NCBI.
- ↑ van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D (September 2008). "18762592". Archives of General Psychiatry. 65 (9): 1062&ndash, 1071. doi:10.1001/archpsyc.65.9.1062. PMID 18762592.
- ↑ Hettema, John M.; Oord, Edwin J.C.G. van den; An, Seon-Sook; Kendler, Kenneth S.; Chen, Xiangning. "Follow-up association study of novel neuroticism gene MAMDC1". Psychiatric Genetics. 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMC 2844892.