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{{Infobox_gene}}
{{Infobox_gene}}
'''Zinc finger and BTB domain containing 1''' is a [[protein]] in humans that is encoded by the ZBTB1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Zinc finger and BTB domain containing 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=22890 }}</ref>


'''Zinc finger and BTB domain containing 1''' is a [[protein]] in humans that is encoded by the ZBTB1 [[gene]].
ZBTB1 is essential for the development of [[lymphocytes]] in mice: [[T cells]] are absent from ZBTB1 mutant mice, and numbers of [[B cells]] and [[natural killer cells]] are reduced.<ref name="pmid22201126">{{cite journal | vauthors = Siggs OM, Li X, Xia Y, Beutler B | title = ZBTB1 is a determinant of lymphoid development | journal = The Journal of Experimental Medicine | volume = 209 | issue = 1 | pages = 19–27 | date = January 2012 | pmid = 22201126 | pmc = 3260866 | doi = 10.1084/jem.20112084 }} </ref><ref name="pmid22753936">{{cite journal | vauthors = Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM | title = Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development | journal = Journal of Immunology | volume = 189 | issue = 3 | pages = 1253–64 | date = August 2012 | pmid = 22753936 | pmc = 3401355 | doi = 10.4049/jimmunol.1200623 }}</ref>
<ref name="entrez">
{{cite web
| title = Entrez Gene: Zinc finger and BTB domain containing 1
| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=22890
| accessdate = 2013-04-23 <!-- T16:16:45.647162-08:00 -->
}}</ref>
 
ZBTB1 is essential for the development of [[lymphocytes]] in mice: [[T cells]] are absent from ZBTB1 mutant mice, and numbers of [[B cells]] and [[natural killer cells]] are reduced
.<ref>Siggs, O.M., Li, X., Xia, Y., and Beutler, B. (2012). ZBTB1 is a determinant of lymphoid development. J Exp Med 209, 19–27.</ref><ref>Punwani, D., Simon, K., Choi, Y., Dutra, A., Gonzalez-Espinosa, D., Pak, E., Naradikian, M., Song, C.-H., Zhang, J., Bodine, D.M., et al. (2012). Transcription Factor Zinc Finger and BTB Domain 1 Is Essential for Lymphocyte Development. J Immunol 189, 1253–1264.</ref>


== References ==
== References ==
{{reflist}}
{{reflist}}
== Further reading ==
{{refbegin | 2}}
{{refend}}


[[Category:Genes on human chromosome 14]]
[[Category:Genes on human chromosome 14]]


{{gene-14-stub}}
{{gene-14-stub}}

Latest revision as of 06:17, 10 January 2019

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Wikidata
View/Edit Human

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.[1]

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.[2][3]

References

  1. ↑ "Entrez Gene: Zinc finger and BTB domain containing 1".
  2. ↑ Siggs OM, Li X, Xia Y, Beutler B (January 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.
  3. ↑ Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.
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