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{{Infobox_gene}}
{{GNF_Protein_box
'''RNA-binding protein 12''' is a [[protein]] that in humans is encoded by the ''RBM12'' [[gene]].<ref name="pmid11435693">{{cite journal | vauthors = Stover C, Gradl G, Jentsch I, Speicher MR, Wieser R, Schwaeble W | title = cDNA cloning, chromosome assignment, and genomic structure of a human gene encoding a novel member of the RBM family | journal = Cytogenet Cell Genet | volume = 92 | issue = 3-4 | pages = 225–30 |date=Jul 2001 | pmid = 11435693 | pmc =  | doi =10.1159/000056908 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RBM12 RNA binding motif protein 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10137| accessdate = }}</ref>
| image = PBB_Protein_RBM12_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wel.
| PDB = {{PDB2|1wel}}, {{PDB2|2cpy}}, {{PDB2|2cqp}}, {{PDB2|2dnn}}
| Name = RNA binding motif protein 12
| HGNCid = 9898
| Symbol = RBM12
| AltSymbols =; HRIHFB2091; KIAA0765; SWAN
| OMIM = 607179
| ECnumber =
| Homologene = 34993
| MGIid = 1922960
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10137
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_006038
    | Hs_RefseqmRNA = NM_006047
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 75710
    | Mm_Ensembl = ENSMUSG00000038171
    | Mm_RefseqmRNA = NM_029397
    | Mm_RefseqProtein = NP_083673
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 155786069
    | Mm_GenLoc_end = 155803363
    | Mm_Uniprot = Q3TKT7
  }}
}}
'''RNA binding motif protein 12''', also known as '''RBM12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RBM12 RNA binding motif protein 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10137| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in two transcript variants. Both variants encode the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: RBM12 RNA binding motif protein 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10137| accessdate = }}</ref>
| summary_text = This gene encodes a protein that contains several [[RNA]]-binding motifs, potential [[transmembrane domains]], and [[proline]]-rich regions. This gene and the gene for [[CPNE1|copine I]] overlap at map location 20q11.21. [[Alternative splicing]] in the 5' UTR results in two transcript variants. Both variants encode the same protein.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Kofler M, Motzny K, Freund C |title=GYF domain proteomics reveals interaction sites in known and novel target proteins. |journal=Mol. Cell Proteomics |volume=4 |issue= 11 |pages= 1797-811 |year= 2006 |pmid= 16120600 |doi= 10.1074/mcp.M500129-MCP200 }}
*{{cite journal  | vauthors=Kofler M, Motzny K, Freund C |title=GYF domain proteomics reveals interaction sites in known and novel target proteins. |journal=Mol. Cell. Proteomics |volume=4 |issue= 11 |pages= 1797–811 |year= 2006 |pmid= 16120600 |doi= 10.1074/mcp.M500129-MCP200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal   |vauthors=Brill LM, Salomon AR, Ficarro SB, etal |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal  | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Stover C, Gradl G, Jentsch I, ''et al.'' |title=cDNA cloning, chromosome assignment, and genomic structure of a human gene encoding a novel member of the RBM family. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 225-30 |year= 2001 |pmid= 11435693 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=10.1093/dnares/5.5.277 }}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi=  }}
*{{cite journal   |vauthors=Ueki N, Oda T, Kondo M, etal |title=Selection system for genes encoding nuclear-targeted proteins. |journal=Nat. Biotechnol. |volume=16 |issue= 13 |pages= 1338–42 |year= 1999 |pmid= 9853615 |doi= 10.1038/4315 }}
*{{cite journal | author=Ueki N, Oda T, Kondo M, ''et al.'' |title=Selection system for genes encoding nuclear-targeted proteins. |journal=Nat. Biotechnol. |volume=16 |issue= 13 |pages= 1338-42 |year= 1999 |pmid= 9853615 |doi= 10.1038/4315 }}
}}
}}
{{refend}}
{{refend}}
==External links==
* {{UCSC genome browser|RBM12}}
* {{UCSC gene details|RBM12}}
{{PDB Gallery|geneid=10137}}
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Latest revision as of 07:17, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RNA-binding protein 12 is a protein that in humans is encoded by the RBM12 gene.[1][2]

This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in two transcript variants. Both variants encode the same protein.[2]

References

  1. ↑ Stover C, Gradl G, Jentsch I, Speicher MR, Wieser R, Schwaeble W (Jul 2001). "cDNA cloning, chromosome assignment, and genomic structure of a human gene encoding a novel member of the RBM family". Cytogenet Cell Genet. 92 (3–4): 225–30. doi:10.1159/000056908. PMID 11435693.
  2. ↑ 2.0 2.1 "Entrez Gene: RBM12 RNA binding motif protein 12".

Further reading

External links



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