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{{Infobox_gene}}
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'''GPI transamidase component PIG-T''' is an [[enzyme]] that in humans is encoded by the ''PIGT'' [[gene]].<ref name="pmid15713669">{{cite journal |vauthors=Vainauskas S, Menon AK | title = Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex | journal = J Biol Chem | volume = 280 | issue = 16 | pages = 16402–9 |date=Apr 2005 | pmid = 15713669 | pmc =  | doi = 10.1074/jbc.M414253200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51604| accessdate = }}</ref><ref name="pmid11483512">{{cite journal |vauthors=Ohishi K, Inoue N, Kinoshita T | title = PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8 | journal = EMBO J. | volume = 20 | issue = 15 | pages = 4088–98 |date=August 2001 | pmid = 11483512 | pmc = 149153 | doi = 10.1093/emboj/20.15.4088 | url = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[protein]] that is involved in [[glycosylphosphatidylinositol]] (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI trans[[amidase]]. GPI transamidase mediates GPI anchoring in the [[endoplasmic reticulum]], by catalyzing the transfer of fully assembled GPI units to proteins.<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Phosphatidylinositol glycan anchor biosynthesis, class T
| HGNCid = 14938
| Symbol = PIGT
| AltSymbols =; CGI-06; FLJ41596; MGC8909; NDAP
| OMIM = 610272
| ECnumber = 
| Homologene = 6134
| MGIid = 1926178
| GeneAtlas_image1 = PBB_GE_PIGT_217770_at_tn.png
| Function = {{GNF_GO|id=GO:0003923 |text = GPI-anchor transamidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}} {{GNF_GO|id=GO:0042765 |text = GPI-anchor transamidase complex}}
| Process = {{GNF_GO|id=GO:0016255 |text = attachment of GPI anchor to protein}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}} {{GNF_GO|id=GO:0051402 |text = neuron apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51604
    | Hs_Ensembl = ENSG00000124155
    | Hs_RefseqProtein = NP_057021
    | Hs_RefseqmRNA = NM_015937
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 43478192
    | Hs_GenLoc_end = 43488298
    | Hs_Uniprot = Q969N2
    | Mm_EntrezGene = 78928
    | Mm_Ensembl = ENSMUSG00000017721
    | Mm_RefseqmRNA = NM_133779
    | Mm_RefseqProtein = NP_598540
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 164188725
    | Mm_GenLoc_end = 164199506
    | Mm_Uniprot = Q3U047
  }}
}}
'''Phosphatidylinositol glycan anchor biosynthesis, class T''', also known as '''PIGT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51604| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
PIGT has been shown to [[Protein-protein interaction|interact]] with [[PIGK]]<ref name=pmid12582175>{{cite journal |last=Ohishi |first=Kazuhito |authorlink= |author2=Nagamune Kisaburo |author3=Maeda Yusuke |author4=Kinoshita Taroh  |date=Apr 2003 |title=Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge |journal=J. Biol. Chem. |volume=278 |issue=16 |pages=13959–67 |publisher= |location = United States| issn = 0021-9258| pmid = 12582175 |doi = 10.1074/jbc.M300586200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[GPAA1]].<ref name=pmid11483512 /><ref name=pmid12052837>{{cite journal |last=Vainauskas |first=Saulius |authorlink= |author2=Maeda Yusuke |author3=Kurniawan Henry |author4=Kinoshita Taroh |author5=Menon Anant K  |date=Aug 2002 |title=Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex |journal=J. Biol. Chem. |volume=277 |issue=34 |pages=30535–42 |publisher= |location = United States| issn = 0021-9258| pmid = 12052837 |doi = 10.1074/jbc.M205402200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
| section_title =  
| summary_text = This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.<ref name="entrez">{{cite web | title = Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51604| accessdate = }}</ref>
}}
==Popular Culture==
The PIGT gene was referenced in a sketch on the TV show [[Armstrong and Miller]] due to the habit of predictive text messaging phones to guess the relatively obscure 'PIGT' when the keys 7448 are pressed, instead of a common swear word.


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Eisenhaber B, Maurer-Stroh S, Novatchkova M, ''et al.'' |title=Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. |journal=Bioessays |volume=25 |issue= 4 |pages= 367-85 |year= 2003 |pmid= 12655644 |doi= 10.1002/bies.10254 }}
*{{cite journal   |vauthors=Eisenhaber B, Maurer-Stroh S, Novatchkova M, etal |title=Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. |journal=BioEssays |volume=25 |issue= 4 |pages= 367–85 |year= 2003 |pmid= 12655644 |doi= 10.1002/bies.10254 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Lai CH, Chou CY, Ch'ang LY, ''et al.'' |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703-13 |year= 2000 |pmid= 10810093 |doi=  }}
*{{cite journal   |vauthors=Lai CH, Chou CY, Ch'ang LY, etal |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703  | pmc=310876 }}
*{{cite journal  | author=Ohishi K, Inoue N, Kinoshita T |title=PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4088-98 |year= 2001 |pmid= 11483512 |doi= 10.1093/emboj/20.15.4088 }}
*{{cite journal  |vauthors=Ohishi K, Inoue N, Kinoshita T |title=PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8 |journal=EMBO J. |volume=20 |issue= 15 |pages= 4088–98 |year= 2001 |pmid= 11483512 |doi= 10.1093/emboj/20.15.4088 | pmc=149153 }}
*{{cite journal | author=Yu Y, Zhang C, Zhou G, ''et al.'' |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392-403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501 }}
*{{cite journal   |vauthors=Yu Y, Zhang C, Zhou G, etal |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392–403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501 | pmc=311073 }}
*{{cite journal | author=Fossey SC, Mychaleckyj JC, Pendleton JK, ''et al.'' |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. |journal=Genomics |volume=76 |issue= 1-3 |pages= 45-57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
*{{cite journal   |vauthors=Fossey SC, Mychaleckyj JC, Pendleton JK, etal |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 |journal=Genomics |volume=76 |issue= 1–3 |pages= 45–57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D }}
*{{cite journal | author=Vainauskas S, Maeda Y, Kurniawan H, ''et al.'' |title=Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30535-42 |year= 2002 |pmid= 12052837 |doi= 10.1074/jbc.M205402200 }}
*{{cite journal   |vauthors=Vainauskas S, Maeda Y, Kurniawan H, etal |title=Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30535–42 |year= 2002 |pmid= 12052837 |doi= 10.1074/jbc.M205402200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Ohishi K, Nagamune K, Maeda Y, Kinoshita T |title=Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13959-67 |year= 2003 |pmid= 12582175 |doi= 10.1074/jbc.M300586200 }}
*{{cite journal  |vauthors=Ohishi K, Nagamune K, Maeda Y, Kinoshita T |title=Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13959–67 |year= 2003 |pmid= 12582175 |doi= 10.1074/jbc.M300586200 }}
*{{cite journal | author=Hong Y, Ohishi K, Kang JY, ''et al.'' |title=Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. |journal=Mol. Biol. Cell |volume=14 |issue= 5 |pages= 1780-9 |year= 2004 |pmid= 12802054 |doi= 10.1091/mbc.E02-12-0794 }}
*{{cite journal   |vauthors=Hong Y, Ohishi K, Kang JY, etal |title=Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins |journal=Mol. Biol. Cell |volume=14 |issue= 5 |pages= 1780–9 |year= 2004 |pmid= 12802054 |doi= 10.1091/mbc.E02-12-0794 | pmc=165076 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Vainauskas S, Menon AK |title=Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 16402-9 |year= 2005 |pmid= 15713669 |doi= 10.1074/jbc.M414253200 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Li HL, Li Z, Qin LY, etal |title=The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis |journal=FEBS Lett. |volume=580 |issue= 7 |pages= 1723–8 |year= 2006 |pmid= 16516892 |doi= 10.1016/j.febslet.2006.02.022 }}
*{{cite journal | author=Li HL, Li Z, Qin LY, ''et al.'' |title=The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. |journal=FEBS Lett. |volume=580 |issue= 7 |pages= 1723-8 |year= 2006 |pmid= 16516892 |doi= 10.1016/j.febslet.2006.02.022 }}
}}
}}
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Latest revision as of 07:17, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.[1][2][3]

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.[2]

Interactions

PIGT has been shown to interact with PIGK[4] and GPAA1.[3][5]

References

  1. ↑ Vainauskas S, Menon AK (Apr 2005). "Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex". J Biol Chem. 280 (16): 16402–9. doi:10.1074/jbc.M414253200. PMID 15713669.
  2. ↑ 2.0 2.1 "Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T".
  3. ↑ 3.0 3.1 Ohishi K, Inoue N, Kinoshita T (August 2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC 149153. PMID 11483512.
  4. ↑ Ohishi, Kazuhito; Nagamune Kisaburo; Maeda Yusuke; Kinoshita Taroh (Apr 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. United States. 278 (16): 13959–67. doi:10.1074/jbc.M300586200. ISSN 0021-9258. PMID 12582175.
  5. ↑ Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (Aug 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. United States. 277 (34): 30535–42. doi:10.1074/jbc.M205402200. ISSN 0021-9258. PMID 12052837.

Further reading



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