RALY: Difference between revisions

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{{Infobox_gene}}
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'''RNA-binding protein Raly''' is a [[protein]] that in humans is encoded by the ''RALY'' [[gene]].<ref name="pmid10500250">{{cite journal | vauthors = Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ | title = Alternative processing of the human and mouse raly genes(1) | journal = Biochim Biophys Acta | volume = 1447 | issue = 1 | pages = 107–12 |date=Nov 1999 | pmid = 10500250 | pmc =  | doi =  10.1016/s0167-4781(99)00126-8}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22913| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RALY_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wf1.
| PDB = {{PDB2|1wf1}}
| Name = RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
| HGNCid = 15921
| Symbol = RALY
| AltSymbols =; MGC117312; P542
| OMIM =
| ECnumber =
| Homologene = 7216
| MGIid = 97850
  | GeneAtlas_image1 = PBB_GE_RALY_201271_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_RALY_gnf1h05579_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0030530 |text = heterogeneous nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22913
    | Hs_Ensembl = ENSG00000125970
    | Hs_RefseqProtein = NP_031393
    | Hs_RefseqmRNA = NM_007367
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 32045113
    | Hs_GenLoc_end = 32131738
    | Hs_Uniprot = Q9UKM9
    | Mm_EntrezGene = 19383
    | Mm_Ensembl = ENSMUSG00000027593
    | Mm_RefseqmRNA = NM_023130
    | Mm_RefseqProtein = NP_075619
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 154482598
    | Mm_GenLoc_end = 154558687
    | Mm_Uniprot = Q64012
  }}
}}
'''RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))''', also known as '''RALY''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22913| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.<ref name="entrez">{{cite web | title = Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22913| accessdate = }}</ref>
| summary_text = In [[infectious mononucleosis]], anti-[[Epstein–Barr virus nuclear antigen 1|EBNA-1]] [[antibodies]] are produced which cross-react with multiple normal human [[proteins]]. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such [[antigen]] is RALY which is a member of the heterogeneous nuclear [[ribonucleoprotein]] gene family.<ref name="entrez" />
}}
}}  
 


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F |title=Phosphoproteomic analysis of the human pituitary. |journal=Pituitary |volume=9 |issue= 2 |pages= 109-20 |year=  |pmid= 16807684 |doi= 10.1007/s11102-006-8916-x }}
*{{cite journal  | vauthors=Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F |title=Phosphoproteomic analysis of the human pituitary |journal=Pituitary |volume=9 |issue= 2 |pages= 109–20 |year=  2006|pmid= 16807684 |doi= 10.1007/s11102-006-8916-x }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ |title=Alternative processing of the human and mouse raly genes(1). |journal=Biochim. Biophys. Acta |volume=1447 |issue= 1 |pages= 107-12 |year= 1999 |pmid= 10500250 |doi=  }}
*{{cite journal  | vauthors=Rhodes GH, Valbracht JR, Nguyen MD, Vaughan JH |title=The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein |journal=J. Autoimmun. |volume=10 |issue= 5 |pages= 447–54 |year= 1997 |pmid= 9376072 |doi= 10.1006/jaut.1997.9996 }}
*{{cite journal  | author=Rhodes GH, Valbracht JR, Nguyen MD, Vaughan JH |title=The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein. |journal=J. Autoimmun. |volume=10 |issue= 5 |pages= 447-54 |year= 1997 |pmid= 9376072 |doi= 10.1006/jaut.1997.9996 }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal   |vauthors=Vaughan JH, Valbracht JR, Nguyen MD, etal |title=Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1 |journal=J. Clin. Invest. |volume=95 |issue= 3 |pages= 1306–15 |year= 1995 |pmid= 7533788 |doi=10.1172/JCI117781  | pmc=441470 }}
*{{cite journal | author=Vaughan JH, Valbracht JR, Nguyen MD, ''et al.'' |title=Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1. |journal=J. Clin. Invest. |volume=95 |issue= 3 |pages= 1306-15 |year= 1995 |pmid= 7533788 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=22913}}
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Latest revision as of 07:17, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RNA-binding protein Raly is a protein that in humans is encoded by the RALY gene.[1][2]

In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.[2]


References

  1. ↑ Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ (Nov 1999). "Alternative processing of the human and mouse raly genes(1)". Biochim Biophys Acta. 1447 (1): 107–12. doi:10.1016/s0167-4781(99)00126-8. PMID 10500250.
  2. ↑ 2.0 2.1 "Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))".

Further reading



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