CSTF1: Difference between revisions

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Latest revision as of 07:18, 10 January 2019

Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.^[1]^[2]^[3]

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.^[3]

Interactions

CSTF1 has been shown to interact with BARD1.^[2]^[4]

References

↑ Takagaki Y, Manley JL (Dec 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". J Biol Chem. 267 (33): 23471–4. PMID 1358884.
↑ ^2.0 ^2.1 Kleiman FE, Manley JL (Mar 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228.
↑ ^3.0 ^3.1 "Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa".
↑ Kleiman, F E; Manley J L (Sep 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. UNITED STATES. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523.

External links

Human CSTF1 genome location and CSTF1 gene details page in the UCSC Genome Browser.

Takagaki Y, MacDonald CC, Shenk T, Manley JL (1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1403–7. Bibcode:1992PNAS...89.1403T. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.
Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
Takagaki Y, Manley JL (1994). "A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein". Nature. 372 (6505): 471–4. Bibcode:1994Natur.372..471T. doi:10.1038/372471a0. PMID 7984242.
Rüegsegger U, Beyer K, Keller W (1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". J. Biol. Chem. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.
Kleiman FE, Manley JL (1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. PMID 10477523.
Takagaki Y, Manley JL (2000). "Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. PMC 85326. PMID 10669729.
Fong N, Bentley DL (2001). "Capping, splicing, and 3′ processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD". Genes Dev. 15 (14): 1783–95. doi:10.1101/gad.889101. PMC 312735. PMID 11459828.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Tsuzuki M, Wu W, Nishikawa H, et al. (2006). "A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats". Cancer Lett. 233 (1): 108–16. doi:10.1016/j.canlet.2005.03.012. PMID 15878232.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[pmid1358884-1] Takagaki Y, Manley JL (Dec 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". J Biol Chem. 267 (33): 23471–4. PMID 1358884.

[pmid11257228-2] 2.0 ^2.1 Kleiman FE, Manley JL (Mar 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228.

[entrez-3] 3.0 ^3.1 "Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa".

[pmid10477523-4] Kleiman, F E; Manley J L (Sep 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. UNITED STATES. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523.

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@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Cleavage stimulation factor 50 kDa subunit''' is a [[protein]] that in humans is encoded by the ''CSTF1'' [[gene]].<ref name="pmid1358884">{{cite journal | vauthors = Takagaki Y, Manley JL | title = A human polyadenylation factor is a G protein beta-subunit homologue | journal = J Biol Chem | volume = 267 | issue = 33 | pages = 23471–4 |date=Dec 1992 | pmid = 1358884 | pmc =  | doi =  }}</ref><ref name="pmid11257228">{{cite journal | vauthors = Kleiman FE, Manley JL | title = The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression | journal = Cell | volume = 104 | issue = 5 | pages = 743–53 |date=Mar 2001 | pmid = 11257228 | pmc =  | doi =10.1016/S0092-8674(01)00270-7  }}</ref><ref name="entrez"/>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
- | HGNCid = 2483
- | Symbol = CSTF1
- | AltSymbols =; CstF-50; CstFp50
- | OMIM = 600369
- | ECnumber =
- | Homologene = 1012
- | MGIid = 1914587
- | GeneAtlas_image1 = PBB_GE_CSTF1_32723_at_tn.png
-  | GeneAtlas_image2 = PBB_GE_CSTF1_202190_at_tn.png
-  | Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006378 |text = mRNA polyadenylation}} {{GNF_GO|id=GO:0006379 |text = mRNA cleavage}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1477
-    | Hs_Ensembl = ENSG00000101138
-    | Hs_RefseqProtein = NP_001028693
-    | Hs_RefseqmRNA = NM_001033521
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 20
-    | Hs_GenLoc_start = 54400834
-    | Hs_GenLoc_end = 54412989
-    | Hs_Uniprot = Q05048
-    | Mm_EntrezGene = 67337
-    | Mm_Ensembl = ENSMUSG00000027498
-    | Mm_RefseqmRNA = NM_024199
-    | Mm_RefseqProtein = NP_077161
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 172062208
-    | Mm_GenLoc_end = 172072291
-    | Mm_Uniprot = Q99LC2
-  }}
-}}
-'''Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa''', also known as '''CSTF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1477| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1477| accessdate = }}</ref>
+| summary_text = This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1477| accessdate = }}</ref>
 }}
+==Interactions==
+CSTF1 has been shown to [[Protein-protein interaction|interact]] with [[BARD1]].<ref name=pmid11257228 /><ref name=pmid10477523>{{cite journal |last=Kleiman |first=F E |author2=Manley J L |date=Sep 1999 |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 |journal=[[Science (journal)|Science]] |volume=285 |issue=5433 |pages=1576–9 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 10477523 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1126/science.285.5433.1576 }}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CSTF1}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Takagaki Y, Manley JL |title=A human polyadenylation factor is a G protein beta-subunit homologue. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23471-4 |year= 1992 |pmid= 1358884 |doi=  }}
+*{{cite journal  | vauthors=Takagaki Y, MacDonald CC, Shenk T, Manley JL |title=The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1403–7 |year= 1992 |pmid= 1741396 |doi=10.1073/pnas.89.4.1403  | pmc=48459  |bibcode=1992PNAS...89.1403T }}
-*{{cite journal  | author=Takagaki Y, MacDonald CC, Shenk T, Manley JL |title=The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1403-7 |year= 1992 |pmid= 1741396 |doi=  }}
+*{{cite journal  | vauthors=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672–83 |year= 1995 |pmid= 7590244 |doi=10.1101/gad.9.21.2672  }}
-*{{cite journal  | author=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672-83 |year= 1995 |pmid= 7590244 |doi=  }}
+*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein |journal=Nature |volume=372 |issue= 6505 |pages= 471–4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0 |bibcode=1994Natur.372..471T }}
-*{{cite journal  | author=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein. |journal=Nature |volume=372 |issue= 6505 |pages= 471-4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0 }}
+*{{cite journal  | vauthors=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107–13 |year= 1996 |pmid= 8626397 |doi=10.1074/jbc.271.11.6107  }}
-*{{cite journal  | author=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107-13 |year= 1996 |pmid= 8626397 |doi=  }}
+*{{cite journal  | vauthors=Kleiman FE, Manley JL |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 |journal=Science |volume=285 |issue= 5433 |pages= 1576–9 |year= 1999 |pmid= 10477523 |doi=10.1126/science.285.5433.1576  }}
-*{{cite journal  | author=Kleiman FE, Manley JL |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. |journal=Science |volume=285 |issue= 5433 |pages= 1576-9 |year= 1999 |pmid= 10477523 |doi=  }}
+*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=10.1128/MCB.20.5.1515-1525.2000  | pmc=85326  }}
-*{{cite journal  | author=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515-25 |year= 2000 |pmid= 10669729 |doi=  }}
+*{{cite journal  | vauthors=Fong N, Bentley DL |title=Capping, splicing, and 3′ processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD |journal=Genes Dev. |volume=15 |issue= 14 |pages= 1783–95 |year= 2001 |pmid= 11459828 |doi= 10.1101/gad.889101  | pmc=312735 }}
-*{{cite journal  | author=Kleiman FE, Manley JL |title=The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. |journal=Cell |volume=104 |issue= 5 |pages= 743-53 |year= 2001 |pmid= 11257228 |doi=  }}
+*{{cite journal  | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal|bibcode=2001Natur.414..865D }}
-*{{cite journal  | author=Fong N, Bentley DL |title=Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD. |journal=Genes Dev. |volume=15 |issue= 14 |pages= 1783-95 |year= 2001 |pmid= 11459828 |doi= 10.1101/gad.889101 }}
+*{{cite journal  | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9  |display-authors=etal}}
-*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
-*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Tsuzuki M, Wu W, Nishikawa H |title=A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats |journal=Cancer Lett. |volume=233 |issue= 1 |pages= 108–16 |year= 2006 |pmid= 15878232 |doi= 10.1016/j.canlet.2005.03.012 |display-authors=etal}}
-*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
-*{{cite journal  | author=Tsuzuki M, Wu W, Nishikawa H, ''et al.'' |title=A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats. |journal=Cancer Lett. |volume=233 |issue= 1 |pages= 108-16 |year= 2006 |pmid= 15878232 |doi= 10.1016/j.canlet.2005.03.012 }}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
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+| update_citations = yes
+}}
+{{gene-20-stub}}

CSTF1: Difference between revisions

Latest revision as of 07:18, 10 January 2019

Contents

Interactions

References

External links

Further reading

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