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{{Infobox_gene}}
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'''Reversion-inducing-cysteine-rich protein with kazal motifs''', also known as '''RECK''', is a human [[gene]],<ref name="entrez">{{cite web | title = Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8434| accessdate = }}</ref> thought to be a [[metastasis suppressor]].
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Reversion-inducing-cysteine-rich protein with kazal motifs
| HGNCid = 11345
| Symbol = RECK
| AltSymbols =; ST15; hRECK
| OMIM = 605227
| ECnumber = 
| Homologene = 9622
| MGIid = 1855698
| GeneAtlas_image1 = PBB_GE_RECK_205407_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008191 |text = metalloendopeptidase inhibitor activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0000300 |text = peripheral to membrane of membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001955 |text = blood vessel maturation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8434
    | Hs_Ensembl = ENSG00000122707
    | Hs_RefseqProtein = NP_066934
    | Hs_RefseqmRNA = NM_021111
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 36026430
    | Hs_GenLoc_end = 36114448
    | Hs_Uniprot = O95980
    | Mm_EntrezGene = 53614
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_016678
    | Mm_RefseqProtein = NP_057887
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Reversion-inducing-cysteine-rich protein with kazal motifs''', also known as '''RECK''', is a human [[gene]],<ref name="entrez">{{cite web | title = Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8434| accessdate = }}</ref> thought to be a [[metastasis suppressor]].


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.<ref name="entrez">{{cite web | title = Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8434| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.<ref name="entrez"/> It is one of the targets of an oncomiR, [[MIRN21]].
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Takahashi C, Sheng Z, Horan TP, ''et al.'' |title=Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13221-6 |year= 1998 |pmid= 9789069 |doi=  }}
*{{cite journal   |vauthors=Takahashi C, Sheng Z, Horan TP, etal |title=Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13221–6 |year= 1998 |pmid= 9789069 |doi=10.1073/pnas.95.22.13221  | pmc=23764 }}
*{{cite journal  | author=Gerstein M |title=Measurement of the effectiveness of transitive sequence comparison, through a third 'intermediate' sequence. |journal=Bioinformatics |volume=14 |issue= 8 |pages= 707-14 |year= 1998 |pmid= 9789096 |doi=  }}
*{{cite journal  | author=Gerstein M |title=Measurement of the effectiveness of transitive sequence comparison, through a third 'intermediate' sequence. |journal=Bioinformatics |volume=14 |issue= 8 |pages= 707–14 |year= 1998 |pmid= 9789096 |doi=10.1093/bioinformatics/14.8.707 }}
*{{cite journal | author=Oh J, Takahashi R, Kondo S, ''et al.'' |title=The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. |journal=Cell |volume=107 |issue= 6 |pages= 789-800 |year= 2002 |pmid= 11747814 |doi=  }}
*{{cite journal   |vauthors=Oh J, Takahashi R, Kondo S, etal |title=The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. |journal=Cell |volume=107 |issue= 6 |pages= 789–800 |year= 2002 |pmid= 11747814 |doi=10.1016/S0092-8674(01)00597-9 }}
*{{cite journal | author=Eisenberg I, Hochner H, Sadeh M, ''et al.'' |title=Establishment of the genomic structure and identification of thirteen single-nucleotide polymorphisms in the human RECK gene. |journal=Cytogenet. Genome Res. |volume=97 |issue= 1-2 |pages= 58-61 |year= 2003 |pmid= 12438739 |doi=  }}
*{{cite journal   |vauthors=Eisenberg I, Hochner H, Sadeh M, etal |title=Establishment of the genomic structure and identification of thirteen single-nucleotide polymorphisms in the human RECK gene. |journal=Cytogenet. Genome Res. |volume=97 |issue= 1–2 |pages= 58–61 |year= 2003 |pmid= 12438739 |doi=10.1159/000064042 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Masui T, Doi R, Koshiba T, ''et al.'' |title=RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. |journal=Clin. Cancer Res. |volume=9 |issue= 5 |pages= 1779-84 |year= 2004 |pmid= 12738734 |doi=  }}
*{{cite journal   |vauthors=Masui T, Doi R, Koshiba T, etal |title=RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. |journal=Clin. Cancer Res. |volume=9 |issue= 5 |pages= 1779–84 |year= 2004 |pmid= 12738734 |doi=  }}
*{{cite journal  | author=Liu LT, Chang HC, Chiang LC, Hung WC |title=Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3069-72 |year= 2003 |pmid= 12810630 |doi=  }}
*{{cite journal  | vauthors=Liu LT, Chang HC, Chiang LC, Hung WC |title=Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3069–72 |year= 2003 |pmid= 12810630 |doi=  }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }}
*{{cite journal | author=Takeuchi T, Hisanaga M, Nagao M, ''et al.'' |title=The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 16 |pages= 5572-9 |year= 2005 |pmid= 15328199 |doi= 10.1158/1078-0432.CCR-03-0656 }}
*{{cite journal   |vauthors=Takeuchi T, Hisanaga M, Nagao M, etal |title=The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 16 |pages= 5572–9 |year= 2005 |pmid= 15328199 |doi= 10.1158/1078-0432.CCR-03-0656 }}
*{{cite journal  | author=Simizu S, Takagi S, Tamura Y, Osada H |title=RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7455-61 |year= 2005 |pmid= 16103099 |doi= 10.1158/0008-5472.CAN-04-4446 }}
*{{cite journal  | vauthors=Simizu S, Takagi S, Tamura Y, Osada H |title=RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7455–61 |year= 2005 |pmid= 16103099 |doi= 10.1158/0008-5472.CAN-04-4446 }}
*{{cite journal  | author=Hsu MC, Chang HC, Hung WC |title=HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4718-25 |year= 2006 |pmid= 16377629 |doi= 10.1074/jbc. M510937200 }}
*{{cite journal  | vauthors=Hsu MC, Chang HC, Hung WC |title=HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4718–25 |year= 2006 |pmid= 16377629 |doi=10.1074/jbc.M510937200 }}
*{{cite journal | author=Correa TC, Brohem CA, Winnischofer SM, ''et al.'' |title=Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness. |journal=J. Cell. Biochem. |volume=99 |issue= 1 |pages= 156-67 |year= 2006 |pmid= 16791855 |doi= 10.1002/jcb.20917 }}
*{{cite journal   |vauthors=Correa TC, Brohem CA, Winnischofer SM, etal |title=Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness. |journal=J. Cell. Biochem. |volume=99 |issue= 1 |pages= 156–67 |year= 2006 |pmid= 16791855 |doi= 10.1002/jcb.20917 }}
*{{cite journal  | author=Chang HC, Cho CY, Hung WC |title=Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8413-20 |year= 2007 |pmid= 16951151 |doi= 10.1158/0008-5472.CAN-06-0685 }}
*{{cite journal  | vauthors=Chang HC, Cho CY, Hung WC |title=Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8413–20 |year= 2007 |pmid= 16951151 |doi= 10.1158/0008-5472.CAN-06-0685 }}
*{{cite journal | author=Lei H, Hemminki K, Altieri A, ''et al.'' |title=Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. |journal=Breast Cancer Res. Treat. |volume=103 |issue= 1 |pages= 61-9 |year= 2007 |pmid= 17033924 |doi= 10.1007/s10549-006-9345-2 }}
*{{cite journal   |vauthors=Lei H, Hemminki K, Altieri A, etal |title=Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. |journal=Breast Cancer Res. Treat. |volume=103 |issue= 1 |pages= 61–9 |year= 2007 |pmid= 17033924 |doi= 10.1007/s10549-006-9345-2 }}
*{{cite journal  | author=Chang HC, Cho CY, Hung WC |title=Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer. |journal=Cancer Sci. |volume=98 |issue= 2 |pages= 169-73 |year= 2007 |pmid= 17233834 |doi= 10.1111/j.1349-7006.2006.00367.x }}
*{{cite journal  | vauthors=Chang HC, Cho CY, Hung WC |title=Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer. |journal=Cancer Sci. |volume=98 |issue= 2 |pages= 169–73 |year= 2007 |pmid= 17233834 |doi= 10.1111/j.1349-7006.2006.00367.x }}
*{{cite journal | author=Kang HG, Kim HS, Kim KJ, ''et al.'' |title=RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. |journal=J. Orthop. Res. |volume=25 |issue= 5 |pages= 696-702 |year= 2007 |pmid= 17262820 |doi= 10.1002/jor.20323 }}
*{{cite journal   |vauthors=Kang HG, Kim HS, Kim KJ, etal |title=RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. |journal=J. Orthop. Res. |volume=25 |issue= 5 |pages= 696–702 |year= 2007 |pmid= 17262820 |doi= 10.1002/jor.20323 }}
*{{cite journal | author=Mori T, Moriuchi R, Okazaki E, ''et al.'' |title=Tgat oncoprotein functions as an inhibitor of RECK by association of the unique C-terminal region. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 4 |pages= 937-43 |year= 2007 |pmid= 17328864 |doi= 10.1016/j.bbrc.2007.02.051 }}
*{{cite journal   |vauthors=Mori T, Moriuchi R, Okazaki E, etal |title=Tgat oncoprotein functions as an inhibitor of RECK by association of the unique C-terminal region. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 4 |pages= 937–43 |year= 2007 |pmid= 17328864 |doi= 10.1016/j.bbrc.2007.02.051 }}
*{{cite journal | author=Miki T, Takegami Y, Okawa K, ''et al.'' |title=The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12341-52 |year= 2007 |pmid= 17329256 |doi= 10.1074/jbc. M610948200 }}
*{{cite journal   |vauthors=Miki T, Takegami Y, Okawa K, etal |title=The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12341–52 |year= 2007 |pmid= 17329256 |doi=10.1074/jbc.M610948200 }}
*{{cite journal | author=Cho CY, Wang JH, Chang HC, ''et al.'' |title=Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 1 |pages= 65-9 |year= 2007 |pmid= 17443689 |doi= 10.1002/jcp.21089 }}
*{{cite journal   |vauthors=Cho CY, Wang JH, Chang HC, etal |title=Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 1 |pages= 65–9 |year= 2007 |pmid= 17443689 |doi= 10.1002/jcp.21089 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 07:37, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene,[1] thought to be a metastasis suppressor.

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.[1] It is one of the targets of an oncomiR, MIRN21.

References

  1. ↑ 1.0 1.1 "Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs".

Further reading



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