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{{Infobox_gene}}
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'''Signaling threshold-regulating transmembrane adapter 1''' is a [[protein]] that in humans is encoded by the ''SIT1'' [[gene]].<ref name="pmid11491537">{{cite journal | vauthors = Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E | title = Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT) | journal = Immunogenetics | volume = 53 | issue = 4 | pages = 337–41 |date=Aug 2001 | pmid = 11491537 | pmc =  | doi =10.1007/s002510100328 }}</ref><ref name="pmid10209036">{{cite journal | vauthors = Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B | title = SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation | journal = J Exp Med | volume = 189 | issue = 8 | pages = 1181–94 |date=May 1999 | pmid = 10209036 | pmc = 2193021 | doi =10.1084/jem.189.8.1181 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27240| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Signaling threshold regulating transmembrane adaptor 1
| HGNCid = 17710
| Symbol = SIT1
| AltSymbols =; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SIT
| OMIM = 604964
| ECnumber =
| Homologene = 8694
| MGIid = 1889342
  | GeneAtlas_image1 = PBB_GE_SIT1_205484_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019900 |text = kinase binding}} {{GNF_GO|id=GO:0042169 |text = SH2 domain binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0050863 |text = regulation of T cell activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27240
    | Hs_Ensembl = ENSG00000137078
    | Hs_RefseqProtein = NP_055265
    | Hs_RefseqmRNA = NM_014450
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 35639300
    | Hs_GenLoc_end = 35640947
    | Hs_Uniprot = Q9Y3P8
    | Mm_EntrezGene = 54390
    | Mm_Ensembl = ENSMUSG00000028460
    | Mm_RefseqmRNA = NM_019436
    | Mm_RefseqProtein = NP_062309
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 43503184
    | Mm_GenLoc_end = 43504822
    | Mm_Uniprot = Q8C503
  }}
}}
'''Signaling threshold regulating transmembrane adaptor 1''', also known as '''SIT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27240| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi= }}
*{{cite journal   |vauthors=Adams MD, Kerlavage AR, Fleischmann RD, etal |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=<!-- none available --> |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format=PDF  }}
*{{cite journal  | author=Marie-Cardine A, Kirchgessner H, Bruyns E, ''et al.'' |title=SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. |journal=J. Exp. Med. |volume=189 |issue= 8 |pages= 1181-94 |year= 1999 |pmid= 10209036 |doi= }}
*{{cite journal   |vauthors=Pfrepper KI, Marie-Cardine A, Simeoni L, etal |title=Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein) |journal=Eur. J. Immunol. |volume=31 |issue= 6 |pages= 1825–36 |year= 2001 |pmid= 11433379 |doi=10.1002/1521-4141(200106)31:6<1825::AID-IMMU1825>3.0.CO;2-V }}
*{{cite journal | author=Pfrepper KI, Marie-Cardine A, Simeoni L, ''et al.'' |title=Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). |journal=Eur. J. Immunol. |volume=31 |issue= 6 |pages= 1825-36 |year= 2001 |pmid= 11433379 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Hübener C, Mincheva A, Lichter P, ''et al.'' |title=Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT). |journal=Immunogenetics |volume=53 |issue= 4 |pages= 337-41 |year= 2001 |pmid= 11491537 |doi= }}
*{{cite journal   |vauthors=Brill LM, Salomon AR, Ficarro SB, etal |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal   |vauthors=Ficarro SB, Salomon AR, Brill LM, etal |title=Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites |journal=Rapid Commun. Mass Spectrom. |volume=19 |issue= 1 |pages= 57–71 |year= 2005 |pmid= 15570572 |doi= 10.1002/rcm.1746 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Ficarro SB, Salomon AR, Brill LM, ''et al.'' |title=Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites. |journal=Rapid Commun. Mass Spectrom. |volume=19 |issue= 1 |pages= 57-71 |year= 2005 |pmid= 15570572 |doi= 10.1002/rcm.1746 }}
*{{cite journal   |vauthors=Tao WA, Wollscheid B, O'Brien R, etal |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal   |vauthors=Tedoldi S, Paterson JC, Hansmann ML, etal |title=Transmembrane adaptor molecules: a new category of lymphoid-cell markers |journal=Blood |volume=107 |issue= 1 |pages= 213–21 |year= 2006 |pmid= 16160011 |doi= 10.1182/blood-2005-06-2273 }}
*{{cite journal | author=Tao WA, Wollscheid B, O'Brien R, ''et al.'' |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591-8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776 }}
*{{cite journal | author=Tedoldi S, Paterson JC, Hansmann ML, ''et al.'' |title=Transmembrane adaptor molecules: a new category of lymphoid-cell markers. |journal=Blood |volume=107 |issue= 1 |pages= 213-21 |year= 2006 |pmid= 16160011 |doi= 10.1182/blood-2005-06-2273 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-9-stub}}

Latest revision as of 07:37, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Signaling threshold-regulating transmembrane adapter 1 is a protein that in humans is encoded by the SIT1 gene.[1][2][3]


References

  1. ↑ Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Aug 2001). "Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT)". Immunogenetics. 53 (4): 337–41. doi:10.1007/s002510100328. PMID 11491537.
  2. ↑ Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B (May 1999). "SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation". J Exp Med. 189 (8): 1181–94. doi:10.1084/jem.189.8.1181. PMC 2193021. PMID 10209036.
  3. ↑ "Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1".

Further reading



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