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{{Infobox_gene}}
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'''[[Osteoclast]]-stimulating factor 1''' is a [[protein]] that in [[human]]s is encoded by the ''OSTF1'' [[gene]].<ref name="pmid10092216">{{cite journal | vauthors = Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD | title = Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption | journal = J Cell Physiol | volume = 177 | issue = 4 | pages = 636–45 |date=Apr 1999 | pmid = 10092216 | pmc =  | doi = 10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OSTF1 osteoclast stimulating factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26578| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_OSTF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x2k.
| PDB = {{PDB2|1x2k}}, {{PDB2|1zlm}}
| Name = Osteoclast stimulating factor 1
| HGNCid = 8510
| Symbol = OSTF1
| AltSymbols =; FLJ20559; OSF; SH3P2; bA235O14.1
| OMIM = 610180
| ECnumber =
| Homologene = 8227
| MGIid = 700012
  | GeneAtlas_image1 = PBB_GE_OSTF1_204479_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26578
    | Hs_Ensembl = ENSG00000134996
    | Hs_RefseqProtein = NP_036515
    | Hs_RefseqmRNA = NM_012383
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 76893279
    | Hs_GenLoc_end = 76952001
    | Hs_Uniprot = Q92882
    | Mm_EntrezGene = 20409
    | Mm_Ensembl = ENSMUSG00000024725
    | Mm_RefseqmRNA = NM_017375
    | Mm_RefseqProtein = NP_059071
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 18648289
    | Mm_GenLoc_end = 18671232
    | Mm_Uniprot = Q62422
  }}
}}
'''Osteoclast stimulating factor 1''', also known as '''OSTF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OSTF1 osteoclast stimulating factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26578| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Sparks AB, Hoffman NG, McConnell SJ, ''et al.'' |title=Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. |journal=Nat. Biotechnol. |volume=14 |issue= 6 |pages= 741-4 |year= 1998 |pmid= 9630982 |doi= 10.1038/nbt0696-741 }}
*{{cite journal   |vauthors=Sparks AB, Hoffman NG, McConnell SJ, etal |title=Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins |journal=Nat. Biotechnol. |volume=14 |issue= 6 |pages= 741–4 |year= 1998 |pmid= 9630982 |doi= 10.1038/nbt0696-741 }}
*{{cite journal | author=Reddy S, Devlin R, Menaa C, ''et al.'' |title=Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption. |journal=J. Cell. Physiol. |volume=177 |issue= 4 |pages= 636-45 |year= 1999 |pmid= 10092216 |doi= 10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H }}
*{{cite journal   |vauthors=Schaub R, Dupont B, Roodman GD, etal |title=Assignment of OSTF1 to human chromosome bands 12q24.1→q24.2 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1–2 |pages= 87–8 |year= 2000 |pmid= 10773673 |doi=10.1159/000015492 }}
*{{cite journal  | author=Schaub R, Dupont B, Roodman GD, ''et al.'' |title=Assignment of OSTF1 to human chromosome bands 12q24.1-->q24.2 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 87-8 |year= 2000 |pmid= 10773673 |doi=  }}
*{{cite journal   |vauthors=Kurihara N, Menaa C, Maeda H, etal |title=Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41035–9 |year= 2001 |pmid= 11551898 |doi= 10.1074/jbc.M100233200 }}
*{{cite journal | author=Kurihara N, Menaa C, Maeda H, ''et al.'' |title=Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41035-9 |year= 2001 |pmid= 11551898 |doi= 10.1074/jbc.M100233200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Szymkiewicz I, Destaing O, Jurdic P, Dikic I |title=SH3P2 in complex with Cbl and Src |journal=FEBS Lett. |volume=565 |issue= 1–3 |pages= 33–8 |year= 2004 |pmid= 15135048 |doi= 10.1016/j.febslet.2004.03.100 }}
*{{cite journal  | author=Szymkiewicz I, Destaing O, Jurdic P, Dikic I |title=SH3P2 in complex with Cbl and Src. |journal=FEBS Lett. |volume=565 |issue= 1-3 |pages= 33-8 |year= 2004 |pmid= 15135048 |doi= 10.1016/j.febslet.2004.03.100 }}
*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Li M, Meng Z, Xu Y, etal |title=Crystallization and preliminary X-ray crystallographic analysis of osteoclast-stimulating factor |journal=Acta Crystallographica Section F |volume=61 |issue= Pt 1 |pages= 128–30 |year= 2006 |pmid= 16508112 |doi= 10.1107/S1744309104031653 | pmc=1952375 }}
*{{cite journal | author=Li M, Meng Z, Xu Y, ''et al.'' |title=Crystallization and preliminary X-ray crystallographic analysis of osteoclast-stimulating factor. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=61 |issue= Pt 1 |pages= 128-30 |year= 2006 |pmid= 16508112 |doi= 10.1107/S1744309104031653 }}
*{{cite journal   |vauthors=Chen L, Wang Y, Wells D, etal |title=Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution |journal=Acta Crystallographica Section F |volume=62 |issue= Pt 9 |pages= 844–8 |year= 2006 |pmid= 16946461 |doi= 10.1107/S1744309106030004 | pmc=2242886 }}
*{{cite journal | author=Chen L, Wang Y, Wells D, ''et al.'' |title=Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=62 |issue= Pt 9 |pages= 844-8 |year= 2006 |pmid= 16946461 |doi= 10.1107/S1744309106030004 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=26578}}
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Latest revision as of 07:38, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Osteoclast-stimulating factor 1 is a protein that in humans is encoded by the OSTF1 gene.[1][2]


References

  1. ↑ Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD (Apr 1999). "Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption". J Cell Physiol. 177 (4): 636–45. doi:10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H. PMID 10092216.
  2. ↑ "Entrez Gene: OSTF1 osteoclast stimulating factor 1".

Further reading



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