CIZ1: Difference between revisions
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== Clinical significance == | == Clinical significance == | ||
An altered circulating form of the Ciz1 protein is synthesized by [[lung cancer]] cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a [[biomarker]] for early detection of lung cancer.<ref name="pmid23074256">{{cite journal | vauthors = Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D | title = Variant Ciz1 is a circulating biomarker for early-stage lung cancer | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 109| issue = 45| pages = E3128–35|date=October 2012 | pmid = 23074256 | doi = 10.1073/pnas.1210107109 | url = }}</ref> | An altered circulating form of the Ciz1 protein is synthesized by [[lung cancer]] cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a [[biomarker]] for early detection of lung cancer.<ref name="pmid23074256">{{cite journal | vauthors = Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D | title = Variant Ciz1 is a circulating biomarker for early-stage lung cancer | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 109| issue = 45| pages = E3128–35|date=October 2012 | pmid = 23074256 | doi = 10.1073/pnas.1210107109 | url = | pmc = 3494940}}</ref> | ||
== Interactions == | == Interactions == | ||
Latest revision as of 07:40, 10 January 2019
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Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[1][2]
Function
The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[2]
Clinical significance
An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[3]
Interactions
CIZ1 has been shown to interact with P21.[1]
References
- ↑ 1.0 1.1 Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (Dec 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochem Biophys Res Commun. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.
- ↑ 2.0 2.1 "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".
- ↑ Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D (October 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proc. Natl. Acad. Sci. U.S.A. 109 (45): E3128–35. doi:10.1073/pnas.1210107109. PMC 3494940. PMID 23074256.
External links
- Human CIZ1 genome location and CIZ1 gene details page in the UCSC Genome Browser.
Further reading
- Lukasik A, Uniewicz KA, Kulis M, Kozlowski P (2008). "Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog". FEBS J. 275 (2): 332–40. doi:10.1111/j.1742-4658.2007.06203.x. PMID 18081865.
- Rahman FA, Ainscough JF, Copeland N, Coverley D (2007). "Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1". Hum. Mutat. 28 (10): 993–1004. doi:10.1002/humu.20550. PMID 17508423.
- den Hollander P, Rayala SK, Coverley D, Kumar R (2006). "Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action". Cancer Res. 66 (22): 11021–9. doi:10.1158/0008-5472.CAN-06-2336. PMID 17108141.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Coverley D, Marr J, Ainscough J (2005). "Ciz1 promotes mammalian DNA replication". J. Cell Sci. 118 (Pt 1): 101–12. doi:10.1242/jcs.01599. PMID 15585571.
- Warder DE, Keherly MJ (2004). "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC". J. Biomed. Sci. 10 (4): 406–17. doi:10.1159/000071160. PMID 12824700.
- Gilley J, Fried M (1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Hum. Mol. Genet. 8 (7): 1313–20. doi:10.1093/hmg/8.7.1313. PMID 10369878.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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