UHRF2: Difference between revisions
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'''E3 ubiquitin-protein ligase UHRF2''' is an [[enzyme]] that in humans is encoded by the ''UHRF2'' [[gene]].<ref name="pmid12176013">{{cite journal | vauthors = Mori T, Li Y, Hata H, Ono K, Kochi H | title = NIRF, a novel RING finger protein, is involved in cell-cycle regulation | journal = Biochem Biophys Res Commun | volume = 296 | issue = 3 | pages = 530–6 |date=Aug 2002 | pmid = 12176013 | pmc = | doi =10.1016/S0006-291X(02)00890-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115426| accessdate = }}</ref> | '''E3 ubiquitin-protein ligase UHRF2''' is an [[enzyme]] that in humans is encoded by the ''UHRF2'' [[gene]].<ref name="pmid12176013">{{cite journal | vauthors = Mori T, Li Y, Hata H, Ono K, Kochi H | title = NIRF, a novel RING finger protein, is involved in cell-cycle regulation | journal = Biochem Biophys Res Commun | volume = 296 | issue = 3 | pages = 530–6 |date=Aug 2002 | pmid = 12176013 | pmc = | doi =10.1016/S0006-291X(02)00890-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115426| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.<ref name="entrez">{{cite web | title = Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115426| accessdate = }}</ref> | | summary_text = This gene encodes a [[nuclear protein]] which is involved in [[cell-cycle regulation]]. The encoded protein is a [[ubiquitin ligase|ubiquitin-ligase]] capable of [[Ubiquitin|ubiquinating]] PCNP ([[PEST sequence|PEST]]-containing nuclear protein), and together they may play a role in [[tumorigenesis]].<ref name="entrez">{{cite web | title = Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115426| accessdate = }}</ref> | ||
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Latest revision as of 07:40, 10 January 2019
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E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.[1][2]
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.[2]
References
- ↑ Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun. 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013.
- ↑ 2.0 2.1 "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2".
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain". Oncogene. 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2". Biochem. Biophys. Res. Commun. 319 (2): 464–8. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein". FEBS Lett. 557 (1–3): 209–14. doi:10.1016/S0014-5793(03)01495-9. PMID 14741369.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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