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{{Underlinked|date=September 2017}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Ribonuclease UK114''' is an [[enzyme]] that in humans is encoded by the ''HRSP12'' [[gene]].<ref name="pmid8973653">{{cite journal |vauthors=Schmiedeknecht G, Kerkhoff C, Orso E, Stohr J, Aslanidis C, Nagy GM, Knuechel R, Schmitz G | title = Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation | journal = Eur J Biochem | volume = 242 | issue = 2 | pages = 339–51 |date=Jan 1997 | pmid = 8973653 | pmc = | doi =10.1111/j.1432-1033.1996.0339r.x }}</ref><ref name="pmid9405234">{{cite journal |vauthors=Schmiedeknecht G, Buchler C, Schmitz G | title = A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1 | journal = Biochem Biophys Res Commun | volume = 241 | issue = 1 | pages = 59–67 |date=Jan 1998 | pmid = 9405234 | pmc = | doi = 10.1006/bbrc.1997.7772 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HRSP12 heat-responsive protein 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10247| accessdate = }}</ref>
'''Ribonuclease UK114''' is an [[enzyme]] that in humans is encoded by the ''HRSP12'' [[gene]].<ref name="pmid8973653">{{cite journal |vauthors=Schmiedeknecht G, Kerkhoff C, Orso E, Stohr J, Aslanidis C, Nagy GM, Knuechel R, Schmitz G | title = Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation | journal = Eur J Biochem | volume = 242 | issue = 2 | pages = 339–51 |date=Jan 1997 | pmid = 8973653 | pmc = | doi =10.1111/j.1432-1033.1996.0339r.x }}</ref><ref name="pmid9405234">{{cite journal |vauthors=Schmiedeknecht G, Buchler C, Schmitz G | title = A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1 | journal = Biochem Biophys Res Commun | volume = 241 | issue = 1 | pages = 59–67 |date=Jan 1998 | pmid = 9405234 | pmc = | doi = 10.1006/bbrc.1997.7772 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HRSP12 heat-responsive protein 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10247| accessdate = }}</ref>
Ribonuclease UK114 is an enzyme that in humans is encoded by the HRSP12gene.[1][2][3]
References
↑Schmiedeknecht G, Kerkhoff C, Orso E, Stohr J, Aslanidis C, Nagy GM, Knuechel R, Schmitz G (Jan 1997). "Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation". Eur J Biochem. 242 (2): 339–51. doi:10.1111/j.1432-1033.1996.0339r.x. PMID8973653.
↑Schmiedeknecht G, Buchler C, Schmitz G (Jan 1998). "A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1". Biochem Biophys Res Commun. 241 (1): 59–67. doi:10.1006/bbrc.1997.7772. PMID9405234.
Mistiniene E, Pozdniakovaite N, Popendikyte V, Naktinis V (2006). "Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF". Int. J. Biol. Macromol. 37 (1–2): 61–8. doi:10.1016/j.ijbiomac.2005.08.008. PMID16198412.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Kanouchi H, Oka T, Asagi K, et al. (2000). "Expression and cellular distribution of perchloric acid-soluble protein is dependent on the cell-proliferating states of NRK-52E cells". Cell. Mol. Life Sci. 57 (7): 1103–8. doi:10.1007/PL00000746. PMID10961346.
Morishita R, Kawagoshi A, Sawasaki T, et al. (1999). "Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis". J. Biol. Chem. 274 (29): 20688–92. doi:10.1074/jbc.274.29.20688. PMID10400702.
Colombo I, Ceciliani F, Ronchi S, et al. (1998). "cDNA cloning and Escherichia coli expression of UK114 tumor antigen". Biochim. Biophys. Acta. 1442 (1): 49–59. doi:10.1016/s0167-4781(98)00120-1. PMID9767104.
Racca S, Di Carlo F, Bartorelli A, et al. (1998). "Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114". Virchows Arch. 431 (5): 323–8. doi:10.1007/s004280050106. PMID9463573.
Oka T, Tsuji H, Noda C, et al. (1996). "Isolation and characterization of a novel perchloric acid-soluble protein inhibiting cell-free protein synthesis". J. Biol. Chem. 270 (50): 30060–7. doi:10.1074/jbc.270.50.30060. PMID8530410.
1oni: Crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the Yjgf/UK114 protein family
