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'''Mu hemoglobin''' is a human alpha-like globin gene named ''HBM''  [[gene]]. The mRNA is expressed at moderate levels, but the protein is not detected <ref name="pmid2649166">{{cite journal | vauthors = Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ | title = A review of the molecular genetics of the human alpha-globin gene cluster | journal = Blood | volume = 73 | issue = 5 | pages = 1081–104 |date=April 1989 | pmid = 2649166 | doi = | url = http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=2649166 | issn = }}</ref><ref name="pmid2825132">{{cite journal |vauthors=Fischel-Ghodsian N, Nicholls RD, Higgs DR | title = Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene | journal = Nucleic Acids Res. | volume = 15 | issue = 22 | pages = 9215–25 |date=November 1987 | pmid = 2825132 | pmc = 306463 | doi = 10.1093/nar/15.22.9215| url = http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=2825132 | issn = }}</ref><ref name="pmid15855277">{{cite journal  |vauthors=Goh SH, Lee YT, Bhanu NV, etal |title=A newly discovered human alpha-globin gene |journal=Blood |volume=106 |issue=4 |pages=1466–72 |date=August 2005 |pmid=15855277 |pmc=1895206 |doi=10.1182/blood-2005-03-0948 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=15855277}}</ref> The order of genes is: 5' - [[Hemoglobin subunit zeta|zeta]] - pseudozeta - '''mu''' - pseudoalpha-1 - [[HBA2|alpha-2]] - [[Hemoglobin, alpha 1|alpha-1]] - [[HBQ1|theta1]] - 3'.
'''Mu hemoglobin''' is a [[Open_reading_frame#ORF_Predictor|predicted]] protein encoded in the ''HBM''  [[gene]]. The mRNA is expressed at moderate levels, but the protein has not been detected by mass spectrometry.<ref name="pmid2649166">{{cite journal | vauthors = Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ | title = A review of the molecular genetics of the human alpha-globin gene cluster | journal = Blood | volume = 73 | issue = 5 | pages = 1081–104 |date=April 1989 | pmid = 2649166 | doi = | url = http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=2649166 | issn = }}</ref><ref name="pmid2825132">{{cite journal |vauthors=Fischel-Ghodsian N, Nicholls RD, Higgs DR | title = Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene | journal = Nucleic Acids Res. | volume = 15 | issue = 22 | pages = 9215–25 |date=November 1987 | pmid = 2825132 | pmc = 306463 | doi = 10.1093/nar/15.22.9215| url = http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=2825132 | issn = }}</ref><ref name="pmid15855277">{{cite journal  |vauthors=Goh SH, Lee YT, Bhanu NV, etal |title=A newly discovered human alpha-globin gene |journal=Blood |volume=106 |issue=4 |pages=1466–72 |date=August 2005 |pmid=15855277 |pmc=1895206 |doi=10.1182/blood-2005-03-0948 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=15855277}}</ref> The order of genes is: 5' - [[Hemoglobin subunit zeta|zeta]] - pseudozeta - '''mu''' - pseudoalpha-1 - [[HBA2|alpha-2]] - [[Hemoglobin, alpha 1|alpha-1]] - [[HBQ1|theta1]] - 3'.


==References==
==References==

Latest revision as of 09:09, 10 January 2019

hemoglobin, mu
Identifiers
SymbolHBM
Alt. symbolsHBAP2
Entrez3042
HUGO4826
OMIM609639
RefSeqNM_001003938
UniProtQ6B0K9
Other data
LocusChr. 16 p13.3

Mu hemoglobin is a predicted protein encoded in the HBM gene. The mRNA is expressed at moderate levels, but the protein has not been detected by mass spectrometry.[1][2][3] The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.

References

  1. ↑ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (April 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. PMID 2649166.
  2. ↑ Fischel-Ghodsian N, Nicholls RD, Higgs DR (November 1987). "Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene". Nucleic Acids Res. 15 (22): 9215–25. doi:10.1093/nar/15.22.9215. PMC 306463. PMID 2825132.
  3. ↑ Goh SH, Lee YT, Bhanu NV, et al. (August 2005). "A newly discovered human alpha-globin gene". Blood. 106 (4): 1466–72. doi:10.1182/blood-2005-03-0948. PMC 1895206. PMID 15855277.


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